Predictive Biomarkers and Targeted Therapies in the Skin
A targeted therapy may be directed toward a specific cancer based on features of that cancer or a genomic subtype of that cancer based on the presence of druggable targets. A predictive biomarker is a biomarker that helps to predict how well a patient will respond to a particular treatment (in contrast, a prognostic biomarker helps to determine whether a cancer is likely to progress or is indolent in the absence of treatment). The last decade has seen significant progress in the use of targeted therapies in melanoma, basal cell carcinoma, and dermatofibrosarcoma protuberans and also the identification of relevant predictive biomarkers. Future promising directions include Merkel cell carcinoma. There is a need for those involved in the diagnosis and treatment of cutaneous cancers (including pathologists and dermatopathologists) to be aware of these exciting developments.
KeywordsMelanoma Predictive biomarker Targeted therapy Merkel cell Basal cell Dermatofibrosarcoma
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