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Predictive Biomarkers and Targeted Therapies for Lymphoid Malignancies

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Predictive Biomarkers in Oncology

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Abstract

Neoplasms derived from lymphoid cells include precursor lymphoid neoplasms, mature B-cell neoplasms, plasma cell myeloma, mature T- and NK-cell neoplasms, and Hodgkin lymphoma. The morphology and immunophenotype of B-cell neoplasms correlate with various stages of normal B-cell differentiation and are currently used as a basis for their classification and nomenclature. Alterations in the major physiologic pathways in B cells such as the B-cell receptor signaling pathway, T-cell receptor pathway, NF-kB pathway, MAPK pathway, PI3K/AKT1, MTOR pathway, NOTCH signaling pathway, inhibition of apoptosis, impairment of differentiation to plasma cells, and epigenetic alterations play a major role in neoplastic transformation. Advances in understanding of the molecular pathogenesis of lymphomas in recent years, especially using next-generation sequencing, have enabled identification of novel diagnostic, prognostic, and predictive molecular biomarkers. Novel-targeted therapies based on these biomarkers have revolutionized the therapeutic landscape for relapsed and refractory lymphomas.

Chapter includes adapted text extracts from: Pillai RK, Chan WC. Pathogenesis of lymphomas. In: Zain J, Kwak L. (eds) Management of Lymphomas: A Case-Based Approach. Adis, Cham; 2017: 11–31. With permission from Springer Nature.

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Authors and Affiliations

  1. Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA

    Raju K. Pillai, Bharat N. Nathwani & Lixin Yang

Authors
  1. Raju K. Pillai
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  2. Bharat N. Nathwani
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  3. Lixin Yang
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Corresponding author

Correspondence to Raju K. Pillai .

Editor information

Editors and Affiliations

  1. Department of Pathology and Lab Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Sunil Badve

  2. Targos Inc., Issaquah, WA, USA

    George Louis Kumar

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Pillai, R.K., Nathwani, B.N., Yang, L. (2019). Predictive Biomarkers and Targeted Therapies for Lymphoid Malignancies. In: Badve, S., Kumar, G. (eds) Predictive Biomarkers in Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-95228-4_32

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  • DOI: https://doi.org/10.1007/978-3-319-95228-4_32

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-95227-7

  • Online ISBN: 978-3-319-95228-4

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