Skip to main content

Growing Up with Autism: Incorporating Behavioral Management and Medication to Manage Self-Injurious Behavior

  • Chapter
  • First Online:
Pediatric Neuropsychiatry

Abstract

Autism spectrum disorder (ASD) is often complicated by psychiatric and medical comorbidities such as intellectual disability, epilepsy, anxiety, mood disorders, sleep issues, and gastrointestinal problems. Behavioral issues including self-injury and aggression are common and cause need for hospitalization and escalating pharmacotherapeutic intervention. The case described below is of an adolescent whose autism and comorbid intellectual disability were complicated by dangerous self-injury. The optimal management included careful analysis of behavioral reinforcers and institution of both a closely monitored and dynamically modified behavioral plan integrated into his home, school, and therapeutic environment. It also included judicious use of a range of psychotropic medications to ensure safety and maximize his capacity to build skills, utilize available therapies, and flourish in the setting of his complex constellation of challenges.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Duerden EG, et al. Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorder. Brain Struct Funct. 2014;219(4):1251–61. ISSN 1863-2661. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/23644587 >.

    Article  Google Scholar 

  2. Wolff JJ, et al. Repetitive and self-injurious behaviors: associations with caudate volume in autism and fragile X syndrome. J Neurodev Disord. 2013;5(1):12. ISSN 1866-1947. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/23639144 >.

    Article  Google Scholar 

  3. Deon LL, et al. Pallidal deep-brain stimulation associated with complete remission of self-injurious behaviors in a patient with Lesch-Nyhan syndrome: a case report. J Child Neurol. 2012;27(1):117–20. ISSN 1708-8283. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/21940691 >.

    Article  Google Scholar 

  4. Taira T, Kobayashi T, Hori T. Disappearance of self-mutilating behavior in a patient with lesch-nyhan syndrome after bilateral chronic stimulation of the globus pallidus internus. Case report. J Neurosurg. 2003;98(2):414–6. ISSN 0022-3085. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/12593632 >.

    Article  Google Scholar 

  5. Sturm V, et al. DBS in the basolateral amygdala improves symptoms of autism and related self-injurious behavior: a case report and hypothesis on the pathogenesis of the disorder. Front Hum Neurosci. 2012;6:341. ISSN 1662-5161. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/23346052 >.

    PubMed  Google Scholar 

  6. Minshawi NF, et al. Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: integration of psychological and biological theory and approach. J Autism Dev Disord. 2015;5(6):1541–68. ISSN 1573-3432. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/25395094 >.

    Article  Google Scholar 

  7. Richardson C. Self-harm: understanding the causes and treatment options. Nurs Times. 2004;100(15):24–5. ISSN 0954-7762. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/15119257 >.

    PubMed  Google Scholar 

  8. Richardson JS, Zaleski WA. Endogenous opiates and self-mutilation. Am J Psychiatry. 1986;143(7):938–9. ISSN 0002-953X. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/3717448 >.

    CAS  PubMed  Google Scholar 

  9. Sandman CA, et al. The role of proopiomelanocortin (POMC) in sequentially dependent self-injurious behavior. Dev Psychobiol. 2008;50(7):680–9. ISSN 1098-2302. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/18688808 >.

    Article  CAS  Google Scholar 

  10. Baghdadli A, et al. Risk factors for self-injurious behaviours among 222 young children with autistic disorders. J Intellect Disabil Res. 2003;47(Pt 8):622–7. ISSN 0964-2633. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/14641810 >.

    Article  CAS  Google Scholar 

  11. Handen BL, et al. Risk factors for self-injurious behavior in an inpatient psychiatric sample of children with autism spectrum disorder: a naturalistic observation study. J Autism Dev Disord. 2018. ISSN 1573-3432. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/29368233 >.

  12. Arnold LE, et al. Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trials. J Am Acad Child Adolesc Psychiatry. 2003;42(12):1443–50. ISSN 0890-8567. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/14627879 >.

    Article  Google Scholar 

  13. Davis NO, Carter AS. Parenting stress in mothers and fathers of toddlers with autism spectrum disorders: associations with child characteristics. J Autism Dev Disord. 2008;38(7):1278–91. ISSN 0162-3257. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/18240012 >.

    Article  Google Scholar 

  14. Skinner BF. The behavior of organisms; an experimental analysis. New York/London: D. Appleton-Century Company; 1938. p. ix. 457 p.

    Google Scholar 

  15. Cooper JO, Heron TE, Heward WL. Applied behavior analysis. 2nd ed. Upper Saddle River: Pearson/Merrill-Prentice Hall; 2007. xxvii, 770 p. ISBN 01314211319780131421134.

    Google Scholar 

  16. McCracken JT, et al. Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002;347(5):314–21. ISSN 1533-4406. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/12151468 >.

    Article  CAS  Google Scholar 

  17. McDougle CJ, et al. A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Arch Gen Psychiatry. 1998;55(7):633–41. ISSN 0003-990X. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/9672054 >.

    Article  CAS  Google Scholar 

  18. Owen R, et al. Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics. 2009;124(6):1533–40. ISSN 1098-4275. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/19948625 >.

    Article  Google Scholar 

  19. Shea S, et al. Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders. Pediatrics. 2004;114(5):e634–41. ISSN 1098-4275. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/15492353 >.

    Article  Google Scholar 

  20. Parikh MS, Kolevzon A, Hollander E. Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability. J Child Adolesc Psychopharmacol. 2008;18(2):157–78. ISSN 1044-5463. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/18439113 >.

    Article  Google Scholar 

  21. Patel NC, et al. Trends in the use of typical and atypical antipsychotics in children and adolescents. J Am Acad Child Adolesc Psychiatry. 2005;44(6):548–56. ISSN 0890-8567. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/15908837 >.

    Article  Google Scholar 

  22. Cohen D, et al. Absence of cognitive impairment at long-term follow-up in adolescents treated with ECT for severe mood disorder. Am J Psychiatry. 2000;157(3):460–2. ISSN 0002-953X. Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/10698827 >.

    Article  CAS  Google Scholar 

  23. Hammock R, Levine WR, Schroeder SR. Brief report: effects of clozapine on self-injurious behavior of two risperidone nonresponders with mental retardation. J Autism Dev Disord. 2001;31(1):109–13. ISSN 0162-3257. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/11439749 >.

    Article  CAS  Google Scholar 

  24. Janowsky DS, Barnhill LJ, Davis JM. Olanzapine for self-injurious, aggressive, and disruptive behaviors in intellectually disabled adults: a retrospective, open-label, naturalistic trial. J Clin Psychiatry. 2003;64(10):1258–65. ISSN 0160-6689. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/14658977 >.

    Article  CAS  Google Scholar 

  25. McDougle CJ, Kem DL, Posey DJ. Case series: use of ziprasidone for maladaptive symptoms in youths with autism. J Am Acad Child Adolesc Psychiatry. 2002;41(8):921–7. ISSN 0890-8567. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/12164181 >.

    Article  Google Scholar 

  26. Aman MG, et al. Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence. Am J Psychiatry. 2002;159(8):1337–46. ISSN 0002-953X. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/12153826 >.

    Article  Google Scholar 

  27. Snyder R, et al. Effects of risperidone on conduct and disruptive behavior disorders in children with subaverage IQs. J Am Acad Child Adolesc Psychiatry. 2002;41(9):1026–36. ISSN 0890-8567. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/12218423 >.

    Article  Google Scholar 

  28. Malone RP, et al. Olanzapine versus haloperidol in children with autistic disorder: an open pilot study. J Am Acad Child Adolesc Psychiatry. 2001;40(8):887–94. ISSN 0890-8567. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/11501687 >.

    Article  CAS  Google Scholar 

  29. Jaselskis CA, et al. Clonidine treatment of hyperactive and impulsive children with autistic disorder. J Clin Psychopharmacol. 1992;12(5):322–7. ISSN 0271-0749. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/1479049 >.

    Article  CAS  Google Scholar 

  30. Sagar-Ouriaghli I, Lievesley K, Santosh PJ. Propranolol for treating emotional, behavioural, autonomic dysregulation in children and adolescents with autism spectrum disorders. J Psychopharmacol. 2018;269881118756245. ISSN 1461–7285. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/29484909 >.

  31. Accordino RE, et al. Psychopharmacological interventions in autism spectrum disorder. Expert Opin Pharmacother. 2016;17(7):937–52. ISSN 1744-7666. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/26891879 >.

    Article  CAS  Google Scholar 

  32. Bloch MR, et al. Fluoxetine in pathologic skin-picking: open-label and double-blind results. Psychosomatics. 2001;42(4):314–9. ISSN 0033–3182. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/11496020 >.

    Article  CAS  Google Scholar 

  33. Hellings JA, Warnock JK. Self-injurious behavior and serotonin in Prader-Willi syndrome. Psychopharmacol Bull. 1994;30(2):245–50. ISSN 0048-5764. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/7831463 >.

    CAS  PubMed  Google Scholar 

  34. Sovner R, et al. Fluoxetine treatment of depression and associated self-injury in two adults with mental retardation. J Intellect Disabil Res. 1993;37(Pt 3):301–11. ISSN 0964-2633. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/8334322 >.

    PubMed  Google Scholar 

  35. Stout RJ. Fluoxetine for the treatment of compulsive facial picking. Am J Psychiatry. 1990;147(3):370. ISSN 0002-953X. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/2309961 >.

    CAS  PubMed  Google Scholar 

  36. Davanzo PA, et al. Paroxetine treatment of aggression and self-injury in persons with mental retardation. Am J Ment Retard. 1998;102(5):427–37. ISSN 0895-8017. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/9544340 >.

    Article  CAS  Google Scholar 

  37. McDougle CJ, et al. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry. 1996;53(11):1001–8. ISSN 0003-990X. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/8911223 >.

    Article  CAS  Google Scholar 

  38. Garber HJ, et al. Clomipramine treatment of stereotypic behaviors and self-injury in patients with developmental disabilities. J Am Acad Child Adolesc Psychiatry. 1992;31(6):1157–60. ISSN 0890-8567. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/1429420 >.

    Article  CAS  Google Scholar 

  39. Lewis MH, et al. Clomipramine treatment for self-injurious behavior of individuals with mental retardation: a double-blind comparison with placebo. Am J Ment Retard. 1996;100(6):654–65. ISSN 0895-8017. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/8735578 >.

    CAS  PubMed  Google Scholar 

  40. Buitelaar JK, Van Der Gaag RJ, Van Der Hoeven J. Buspirone in the management of anxiety and irritability in children with pervasive developmental disorders: results of an open-label study. J Clin Psychiatry. 1998;59(2):56–9. ISSN 0160-6689. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/9501886 >.

    Article  CAS  Google Scholar 

  41. Chugani DC, et al. Efficacy of low-dose buspirone for restricted and repetitive behavior in young children with autism spectrum disorder: a randomized trial. J Pediatr. 2016;170:45–53.e1-4. ISSN 1097-6833. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/26746121 >.

    Article  CAS  Google Scholar 

  42. Hellings JA, et al. A double-blind, placebo-controlled study of valproate for aggression in youth with pervasive developmental disorders. J Child Adolesc Psychopharmacol. 2005;15(4):682–92. ISSN 1044-5463. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/16190799 >.

    Article  Google Scholar 

  43. Belsito KM, et al. Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebo-controlled trial. J Autism Dev Disord. 2001;31(2):175–81. ISSN 0162-3257. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/11450816 >.

    Article  CAS  Google Scholar 

  44. Serret S, et al. Lithium as a rescue therapy for regression and catatonia features in two SHANK3 patients with autism spectrum disorder: case reports. BMC Psychiatry. 2015;15:107. ISSN 1471-244X. Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/25947967 >.

    Article  Google Scholar 

  45. Siegel M, et al. Preliminary investigation of lithium for mood disorder symptoms in children and adolescents with autism spectrum disorder. J Child Adolesc Psychopharmacol. 2014;24(7):399–402. ISSN 1557-8992. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/25093602 >.

    Article  CAS  Google Scholar 

  46. Roy A, et al. Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review. J Intellect Disabil Res. 2015;59(4):293–306. ISSN 1365-2788. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/24589346 >.

    Article  CAS  Google Scholar 

  47. Symons FJ, Thompson A, Rodriguez MC. Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis. Ment Retard Dev Disabil Res Rev. 2004;10(3):193–200. ISSN 1080-4013. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/15611982 >.

    Article  Google Scholar 

  48. Ghaleiha A, et al. Memantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial. Int J Neuropsychopharmacol. 2013;16(4):783–9. ISSN 1469-5111. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/22999292 >.

    Article  CAS  Google Scholar 

  49. Dean OM, Gray KM, Villagonzalo KA, et al. A randomised, double blind, placebo-controlled trial of a fixed dose of N-acetyl cysteine in children with autistic disorder. Aust N Z J Psychiatry. 2017;51(3):241–9.

    Article  Google Scholar 

  50. Hardan AY, et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry. 2012;71(11):956–61. ISSN 1873-2402. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/22342106 >.

    Article  CAS  Google Scholar 

  51. Wink LK, Adams R, Wang Z, et al. A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder. Mol Autism. 2016;7:26.

    Article  Google Scholar 

  52. Erickson CA, et al. STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study. J Autism Dev Disord. 2014;44(4):958–64. ISSN 1573-3432. Disponível em: < https://www.ncbi.nlm.nih.gov/pubmed/24272415 >.

    Article  Google Scholar 

  53. Consoli A, et al. Medical and developmental risk factors of catatonia in children and adolescents: a prospective case-control study. Schizophr Res. 2012;37(1–3):151–8. ISSN 1573-2509. Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/22401837 >.

    Article  Google Scholar 

  54. Dhossche DM, Wachtel LE. Catatonia is hidden in plain sight among different pediatric disorders: a review article. Pediatr Neurol. 2010;43(5):307–15. ISSN 1873-5150. Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/20933172 >.

    Article  Google Scholar 

  55. Wachtel LE, et al. ECT for self-injury in an autistic boy. Eur Child Adolesc Psychiatry. 2009;18(7):458–63. ISSN 1435-165X. Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/19198918 >.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Almai, A.M., Hauptman, A.J. (2019). Growing Up with Autism: Incorporating Behavioral Management and Medication to Manage Self-Injurious Behavior. In: Hauptman, A., Salpekar, J. (eds) Pediatric Neuropsychiatry. Springer, Cham. https://doi.org/10.1007/978-3-319-94998-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-94998-7_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94997-0

  • Online ISBN: 978-3-319-94998-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics