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Do Vaccines Cause Hepatitis?

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The Clinician’s Vaccine Safety Resource Guide

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Abstract

Natural infection with hepatitis viruses is known to cause hepatitis disease. Natural infection with measles, mumps, rubella and varicella viruses have also been associated with hepatitis, albeit rarely. Thus, measles, mumps, rubella and varicella vaccines, and especially hepatitis A and hepatitis B vaccines, prevent hepatitis disease by protecting against natural infection. Vaccines currently routinely recommended to the general population in the U.S. do not cause hepatitis when administered to immunocompetent persons. Varicella is a live virus vaccine that is contraindicated for most patients with underlying immune deficiencies. If the vaccine is mistakenly administered to severely immune deficient individuals, it can cause hepatitis as well as other complications. Patients with chronic hepatic diseases such as chronic hepatitis B or hepatitis C infection can and should receive all routine vaccinations as recommended by the ACIP. Hepatitis A and hepatitis B vaccines are specifically recommended for such individuals to protect them from these natural infections leading to more severe disease.

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Notes

  1. 1.

    These conclusions do not necessarily consider vaccines recommended only for special populations in the United States such as Yellow Fever vaccine (international travelers) or Smallpox vaccine (military personnel).

References

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Authors and Affiliations

  1. Epidemiologist, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Matthew Z. Dudley PhD, MSPH

  2. Professor, Departments of International Health and Health, Behavior and Society, Director, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Daniel A. Salmon PhD, MPH

  3. Professor Emeritus, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Professor Emeritus, Department of Pediatrics, Johns Hopkins School of Medicine, Director Emeritus, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Neal A. Halsey MD

  4. Professor of Medicine, Pediatrics, Global Health, and Epidemiology, Emory University, Associate Director, Emory Vaccine Center, Director, Center of Excellence for Influenza Research and Surveillance (Emory-UGA CEIRS), Former President, National Foundation for Infectious Diseases (NFID), Atlanta, GA, USA

    Walter A. Orenstein MD, DSc (Hon)

  5. Associate Director for Behavioral Research, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Rupali J. Limaye PhD, MPH, MA

  6. Associate Professor, Pediatrics-Infectious Diseases, University of Colorado School of Medicine, Denver, CO, USA

    Sean T. O’Leary MD, MPH

  7. William H. Foege Professor of Global Health, Professor of Epidemiology and Pediatrics, Emory University, Atlanta, GA, USA

    Saad B. Omer MBBS, PhD, MPH

Authors
  1. Matthew Z. Dudley PhD, MSPH
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  2. Daniel A. Salmon PhD, MPH
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  3. Neal A. Halsey MD
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  4. Walter A. Orenstein MD, DSc (Hon)
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  5. Rupali J. Limaye PhD, MPH, MA
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  6. Sean T. O’Leary MD, MPH
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  7. Saad B. Omer MBBS, PhD, MPH
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Dudley, M.Z. et al. (2018). Do Vaccines Cause Hepatitis?. In: The Clinician’s Vaccine Safety Resource Guide. Springer, Cham. https://doi.org/10.1007/978-3-319-94694-8_38

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  • DOI: https://doi.org/10.1007/978-3-319-94694-8_38

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94693-1

  • Online ISBN: 978-3-319-94694-8

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