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Tetanus, Diphtheria and Pertussis

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The Clinician’s Vaccine Safety Resource Guide

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Abstract

All infants without contraindications should receive three doses of the child formulation of tetanus-diphtheria-pertussis combination vaccine (abbreviation: DTaP; trade names: Daptacel®, Infanrix®), given at 2, 4, and 6 months of age. A fourth dose should be given 6 to 12 months after the third dose, preferably between 15 and 18 months of age. A fifth dose is recommended between 4 and 6 years of age. One dose of the tetanus-diphtheria-pertussis booster vaccine (abbreviation: Tdap; trade names: Boostrix®, Adacel®) should be given to all adolescents between the ages of 11 through 18 years. Tdap vaccine should also be given to all adolescents and adults who have never previously received it, particularly if they will be in contact with newborn infants in the near future.

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Notes

  1. 1.

    A serious adverse event is defined by the Food and Drug Administration (FDA) as resulting “in any of the following outcomes: Death, a life-threatening adverse event, inpatient hospitalization or prolongation of existing hospitalization, a persistent or significant incapacity or substantial disruption of the ability to conduct normal life functions, or a congenital anomaly/birth defect. Important medical events that may not result in death, be life-threatening, or require hospitalization may be considered serious when, based upon appropriate medical judgment, they may jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the outcomes listed in this definition.” This definition is found in Title 21, §312.32 of the Electronic Code of Federal Regulations, which can be accessed at the following link: http://www.ecfr.gov/cgi-bin/text-idx?SID=6b68426ec6d55c78a6799d161ba6754c&mc=true&node =se21.5.312_132&rgn=div8

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Authors and Affiliations

  1. Epidemiologist, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Matthew Z. Dudley PhD, MSPH

  2. Professor, Departments of International Health and Health, Behavior and Society, Director, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Daniel A. Salmon PhD, MPH

  3. Professor Emeritus, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Professor Emeritus, Department of Pediatrics, Johns Hopkins School of Medicine, Director Emeritus, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Neal A. Halsey MD

  4. Professor of Medicine, Pediatrics, Global Health, and Epidemiology, Emory University, Associate Director, Emory Vaccine Center, Director, Center of Excellence for Influenza Research and Surveillance (Emory-UGA CEIRS), Former President, National Foundation for Infectious Diseases (NFID), Atlanta, GA, USA

    Walter A. Orenstein MD, DSc (Hon)

  5. Associate Director for Behavioral Research, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Rupali J. Limaye PhD, MPH, MA

  6. Associate Professor, Pediatrics-Infectious Diseases, University of Colorado School of Medicine, Denver, CO, USA

    Sean T. O’Leary MD, MPH

  7. William H. Foege Professor of Global Health, Professor of Epidemiology and Pediatrics, Emory University, Atlanta, GA, USA

    Saad B. Omer MBBS, PhD, MPH

Authors
  1. Matthew Z. Dudley PhD, MSPH
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  2. Daniel A. Salmon PhD, MPH
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  3. Neal A. Halsey MD
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  4. Walter A. Orenstein MD, DSc (Hon)
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  5. Rupali J. Limaye PhD, MPH, MA
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  6. Sean T. O’Leary MD, MPH
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  7. Saad B. Omer MBBS, PhD, MPH
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Dudley, M.Z. et al. (2018). Tetanus, Diphtheria and Pertussis. In: The Clinician’s Vaccine Safety Resource Guide. Springer, Cham. https://doi.org/10.1007/978-3-319-94694-8_17

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  • DOI: https://doi.org/10.1007/978-3-319-94694-8_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94693-1

  • Online ISBN: 978-3-319-94694-8

  • eBook Packages: MedicineMedicine (R0)

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