Neural Circuits Mediating Fear Learning and Extinction

  • Roger Marek
  • Pankaj SahEmail author
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 21)


The activity of neural circuits that underpin particular behaviours are one of the most interesting questions in neurobiology today. This understanding will not only lead to a detailed understanding of learning and memory formation, but also provides a platform for the development of novel therapeutic approaches to a range of neurological disorders that afflict humans. Among the different behavioural paradigms, Pavlovian fear conditioning and its extinction are two of the most extensively used to study acquisition, consolidation and retrieval of fear-related memories. The amygdala, medial prefrontal cortex (mPFC) and hippocampus are three regions with extensive bidirectional connections, and play key roles in fear processing. In this chapter, we summarise our current understanding of the structure and physiological role of these three regions in fear learning and extinction.


Amygdala Fear Post traumatic stress Learning Anxiety 



This work for funded by grants from the National Health and Medical Research Council of Australia and the Centre for Integrative Brain Function from the Australian Research Council (CE140100007).


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Queensland Brain Institute, The University of QueenslandBrisbaneAustralia

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