Skip to main content

Thoracic Epidural Analgesia

  • Chapter
  • First Online:
  • 800 Accesses

Abstract

For decades, epidural infusions of local anaesthetic have been a mainstay of providing analgesia following abdominal surgery. Early studies suggested that epidural analgesia was associated with better post-operative outcomes: lower rates of respiratory failure, ileus, intraoperative bleeding and thrombosis which appeared to translate to a reduction in peri-operative mortality. However, following the advent of laparoscopic surgery and Enhanced Recovery techniques the peri-operative landscape has now changed. Epidural analgesia is associated with complications that can delay patient recovery, and clinicians are now finding multimodal analgesic techniques that are effective as epidurals at relieving post-operative pain. Because of advances in peri-operative care, much of the evidence that supports outcome benefits of epidural analgesia may no longer be valid. This chapter examines the current evidence for outcome benefits of thoracic epidural analgesia (TEA), and aims to identify the role that TEA may occupy in the future of ERAS for abdominal surgery.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Carli F, Kehlet H, Baldini G, Steel A, McRae K, Slinger P, et al. Evidence basis for regional anesthesia in multidisciplinary fast-track surgical care pathways. Reg Anesth Pain Med. 2011;36(1):63–72.

    Article  CAS  PubMed  Google Scholar 

  2. Varadhan KK, Neal KR, Dejong CHC, Fearon KCH, Ljungqvist O, Lobo DN. The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: a meta-analysis of randomized controlled trials. Clin Nutr. 2010;29(4):434–40.

    Article  PubMed  Google Scholar 

  3. Kettner SC, Willschke H, Marhofer P. Does regional anaesthesia really improve outcome? Br J Anaesth. 2011;107(suppl 1):i90–5.

    Article  PubMed  Google Scholar 

  4. Rawal N. Epidural technique for postoperative pain. Reg Anesth Pain Med. 2012;37(3):310–7.

    Article  PubMed  Google Scholar 

  5. da Silva M, Lomelin D, Tsui J, Klinginsmith M, Tadaki C, Langenfeld S. Pain control for laparoscopic colectomy: an analysis of the incidence and utility of epidural analgesia compared to conventional analgesia. Tech Coloproctol. 2015;19(9):515–20.

    Article  Google Scholar 

  6. Power GE, Warden B, Cooke K. Changing patterns in the acute pain service: epidural versus patient-controlled analgesia. Anaesth Intensive Care. 2005;33:501–5.

    CAS  PubMed  Google Scholar 

  7. Low J, Johnston N, Morris C. Epidural analgesia: first do no harm. Anaesthesia. 2008;63(1):1–3.

    Article  CAS  PubMed  Google Scholar 

  8. Garimella V, Cellini C. Postoperative pain control. Clin Colon Rectal Surg. 2013;26(03):191–6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. DAHL JB, Rosenberg J, Hansen BL, Hjortsø NC, Kehlet H. Differential analgesic effects of low-dose epidural morphine and morphine-bupivacaine at rest and during mobilization after major abdominal surgery. Anesth Analg. 1992;74(3):362–5.

    Article  CAS  PubMed  Google Scholar 

  10. Wu CL, Cohen SR, Richman JM, Rowlingson AJ, Courpas GE, Cheung K, et al. Efficacy of postoperative patient-controlled and continuous infusion epidural analgesia versus intravenous patient-controlled analgesia with opioids: a meta-analysis. Anesthesiology. 2005;103(5):1079–88. quiz 1109–10

    Article  CAS  PubMed  Google Scholar 

  11. Marret E, Remy C, Bonnet F. The postoperative pain forum group. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg. 2007;94(6):665–73.

    Article  CAS  Google Scholar 

  12. Nishimori M, Low JHS, Zheng H, Ballantyne JC. Epidural pain relief versus systemic opioid-based pain relief for abdominal aortic surgery. Cochrane Database Syst Rev. 2012;7:CD005059.

    Google Scholar 

  13. Carli F, Mayo N, Klubien K, Schricker T, Trudel J, Belliveau P. Epidural analgesia enhances functional exercise capacity and health-related quality of life after colonic surgery: results of a randomized trial. Anesthesiology. 2002;97(3):540.

    Article  PubMed  Google Scholar 

  14. Farrar JT, Berlin JA, Strom BL. Clinically important changes in acute pain outcome measures. J Pain Symptom Manag. 2003;25(5):406–11.

    Article  Google Scholar 

  15. Olsen MF, Bjerre E, Hansen MD, Hilden J, Landler NE, Tendal B, Hróbjartsson A. Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain. BMC Med. 2017;15(1):35.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Rigg JRA, Jamrozik K, Myles PS, Silbert BS, Peyton PJ, Parsons RW, et al. Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet. 2002;359(9314):1276–82.

    Article  PubMed  Google Scholar 

  17. Mann C, Pouzeratte Y, Boccara G, Peccoux C, Vergne C, Brunat G, et al. Comparison of intravenous or epidural patient-controlled analgesia in the elderly after major abdominal surgery. Anesthesiology. 2000;92(2):433–41.

    Article  CAS  PubMed  Google Scholar 

  18. Albrecht E, Kirkham KR, Liu SS, Brull R. Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis. Anaesthesia. 2012;68(1):79–90.

    Article  PubMed  CAS  Google Scholar 

  19. Ventham NT, Hughes M, O'Neill S, Johns N, Brady RR, Wigmore SJ. Systematic review and meta-analysis of continuous local anaesthetic wound infiltration versus epidural analgesia for postoperative pain following abdominal surgery. Br J Surg. 2013;100(10):1280–9.

    Article  CAS  Google Scholar 

  20. Bell R, Pandanaboyana S, Prasad KR. Epidural versus local anaesthetic infiltration via wound catheters in open liver resection: a meta-analysis. ANZ J Surg. 2015;85(1–2):16–21.

    Article  PubMed  Google Scholar 

  21. Mungroop TH, Veelo DP, Busch OR. Continuous wound infiltration versus epidural analgesia after hepato-pancreato-biliary surgery (POP-UP): a randomised controlled, open-label, non-inferiority trial. Lancet. 2016;1:105–13.

    Google Scholar 

  22. Hughes MJ, Harrison EM, Peel NJ, Stutchfield B, McNally S, Beattie C, Wigmore SJ. Randomized clinical trial of perioperative nerve block and continuous local anaesthetic infiltration via wound catheter versus epidural analgesia in open liver resection (LIVER 2 trial). Br J Surg. 2015;102(13):1619–28.

    Article  CAS  Google Scholar 

  23. Niraj G, Kelkar A, Hart E, Horst C, Malik D, Yeow C, et al. Comparison of analgesic efficacy of four-quadrant transversus abdominis plane (TAP) block and continuous posterior TAP analgesia with epidural analgesia in patients undergoing laparoscopic colorectal surgery: an open-label, randomised, non-inferiority trial. Anaesthesia. 2014;69(4):348–55.

    Article  CAS  PubMed  Google Scholar 

  24. Kuo CP, Jao SW, Chen KM, Wong CS, Yeh CC, Sheen MJ, Wu CT. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth. 2006;97(5):640–6.

    Article  CAS  PubMed  Google Scholar 

  25. Swenson BR, Gottschalk A, Wells LT, Rowlingson JC, Thompson PW, Barclay M, et al. Intravenous lidocaine is as effective as epidural bupivacaine in reducing ileus duration, hospital stay, and pain after open colon resection: a randomized clinical trial. Reg Anesth Pain Med. 2010;35(4):370–6.

    Article  CAS  PubMed  Google Scholar 

  26. Veenhof AAFA, Vlug MS, van der Pas MHGM, Sietses C, van der Peet DL, de Lange-de Klerk ESM, et al. Surgical stress response and postoperative immune function after laparoscopy or open surgery with fast track or standard perioperative care. Ann Surg. 2012;255(2):216–21.

    Article  CAS  PubMed  Google Scholar 

  27. Schwenk W, Haase O, Neudecker J, Müller JM. Short term benefits for laparoscopic colorectal resection. Cochrane Database Syst Rev. 2005;3:CD003145.

    Google Scholar 

  28. Levy BF, Tilney HS, Dowson HMP, Rockall TA. A systematic review of postoperative analgesia following laparoscopic colorectal surgery. Colorect Dis. 2010;12(1):5–15.

    Article  CAS  Google Scholar 

  29. Levy BF, Scott MJ, Fawcett W, Fry C, Rockall TA. Randomized clinical trial of epidural, spinal or patient-controlled analgesia for patients undergoing laparoscopic colorectal surgery. Br J Surg. 2011;98(8):1068–78.

    Article  CAS  PubMed  Google Scholar 

  30. Hübner M, Blanc C, Roulin D, Winiker M, Gander S, Demartines N. Randomized clinical trial on epidural versus patient-controlled analgesia for laparoscopic colorectal surgery within an enhanced recovery pathway. Ann Surg. 2015;261(4):648–53.

    Article  PubMed  Google Scholar 

  31. Barr J, Boulind C, Foster JD, Ewings P, Reid J, Jenkins JT, et al. Impact of analgesic modality on stress response following laparoscopic colorectal surgery: a post-hoc analysis of a randomised controlled trial. Tech Coloproctol. 2015;19(4):231–9.

    Article  CAS  PubMed  Google Scholar 

  32. Ahlers O, Nachtigall I, Lenze J, Goldmann A, Schulte E, Höhne C, et al. Intraoperative thoracic epidural anaesthesia attenuates stress-induced immunosuppression in patients undergoing major abdominal surgery. Br J Anaesth. 2008;101(6):781–7.

    Article  CAS  PubMed  Google Scholar 

  33. Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008;248(2):189–98.

    Article  PubMed  Google Scholar 

  34. Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundert A, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000;321(7275):1493.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. POISE Study Group, Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet. 2008;371(9627):1839–47.

    Article  CAS  Google Scholar 

  36. Meissner A, Rolf N, Van Aken H. Thoracic epidural anesthesia and the patient with heart disease: benefits, risks, and controversies. Anesth Analg. 1997;85(3):517–28.

    Article  CAS  PubMed  Google Scholar 

  37. Park WY, Thompson JS, Lee KK. Effect of epidural anesthesia and analgesia on perioperative outcome: a randomized, controlled Veterans Affairs cooperative study. Ann Surg. 2001;234(4):560–9. discussion 569–71

    Article  CAS  PubMed  Google Scholar 

  38. WU C, HURLEY R, ANDERSON G, HERBERT R, ROWLINGSON A, FLEISHER L. Effect of postoperative epidural analgesia on morbidity and mortality following surgery in medicare patients. Reg Anesth Pain Med. 2004;29(6):525–33.

    Article  PubMed  Google Scholar 

  39. Wijeysundera DN, Beattie WS, Austin PC, Hux JE, Laupacis A. Epidural anaesthesia and survival after intermediate-to-high risk non-cardiac surgery: a population-based cohort study. Lancet. 2008;372(9638):562–9.

    Article  PubMed  Google Scholar 

  40. Guay J, Choi P, Suresh S, Albert N, Kopp S, Pace NL. Neuraxial blockade for the prevention of postoperative mortality and major morbidity: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2014;1:CD010108.

    Google Scholar 

  41. Pöpping DM, Elia N, Van Aken HK, Marret E, Schug SA, Kranke P, et al. Impact of epidural analgesia on mortality and morbidity after surgery. Ann Surg. 2014;259(6):1056–67.

    Article  PubMed  Google Scholar 

  42. Pöpping DM, Elia N, Van Aken HK, Marret E, Schug SA, Kranke P, et al. Impact of epidural analgesia on mortality and morbidity after surgery, supplementary Fig. C, supplemental digital content Fig. C. Ann Surg. 2014;259(6):1056–67. http://links.lww.com/SLA/A469. Accessed Apr 2017

    Article  PubMed  Google Scholar 

  43. Grosso G, Biondi A, Marventano S, Mistretta A, Calabrese G, Basile F. Major postoperative complications and survival for colon cancer elderly patients. BMC Surg. 2012;12(Suppl 1):S20.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Reiz S. Circulatory effects of epidural anesthesia in patients with cardiac disease. Acta Anaesthesiol Belg. 1988;39(3 Suppl 2):21–7.

    CAS  PubMed  Google Scholar 

  45. Goertz AW, Seeling W, Heinrich H, Lindner KH, Schirmir U. Influence of high thoracic epidural anesthesia on left ventricular contractility assessed using the end-systolic pressure-length relationship. Acta Anaesthesiol Scand. 1993;37(1):38–44.

    Article  CAS  PubMed  Google Scholar 

  46. Chaney MA. Intrathecal and epidural anesthesia and analgesia for cardiac surgery. Anesth Analg. 2006;102(1):45–64.

    Article  CAS  PubMed  Google Scholar 

  47. Nygard E. Effects of high thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease. Circulation. 2005;111(17):2165–70.

    Article  CAS  PubMed  Google Scholar 

  48. Gurses E, Berk D, Sungurtekin H, Mete A. Effects of high thoracic epidural anesthesia on mixed venous oxygen saturation in coronary artery bypass grafting surgery. Med Sci Monit. 2013;19:222–9.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Loick HM, Schmidt C, Van Aken H, Junker R, Erren M, Berendes E, et al. High thoracic epidural anesthesia, but not clonidine, attenuates the perioperative stress response via sympatholysis and reduces the release of troponin T in patients undergoing coronary artery bypass grafting. Anesth Analg. 1999;88(4):701–9.

    Article  CAS  PubMed  Google Scholar 

  50. Berendes E, Schmidt C, Van Aken H. Reversible cardiac sympathectomy by high thoracic epidural anesthesia improves regional left ventricular function in patients undergoing coronary artery bypass grafting. Arch Surg. 2003;138:1283–90.

    Article  PubMed  Google Scholar 

  51. Hainsworth R. Vascular capacitance: its control and importance. Rev Physiol Biochem Pharmacol. 1986;105:101–73.

    Article  CAS  PubMed  Google Scholar 

  52. Baron JF, Payen D, Coriat P, Edouard A. Forearm vascular tone and reactivity during lumbar epidural anesthesia. Anesth Analg. 1988;67:1065–70.

    Article  CAS  PubMed  Google Scholar 

  53. Richman JM, Rowlingson AJ, Maine DN, Courpas GE, Weller JF, Wu CL. Does neuraxial anesthesia reduce intraoperative blood loss? A meta-analysis. J Clin Anesth. 2006;18(6):427–35.

    Article  PubMed  Google Scholar 

  54. Guay J. The effect of neuraxial blocks on surgical blood loss and blood transfusion requirements: a meta-analysis. J Clin Anesth. 2006;18(2):124–8.

    Article  PubMed  Google Scholar 

  55. Pöpping DM, Zahn PK, Van Aken HK, Dasch B, Boche R, Pogatzki-Zahn EM. Effectiveness and safety of postoperative pain management: a survey of 18 925 consecutive patients between 1998 and 2006 (2nd revision): a database analysis of prospectively raised data. Br J Anaesth. 2008;101(6):832–40.

    Article  PubMed  Google Scholar 

  56. Leslie K, Myles P, Devereaux P, Williamson E, Rao-Melancini P, Forbes A, et al. Neuraxial block, death and serious cardiovascular morbidity in the POISE trial. Br J Anaesth. 2013;111(3):382–90.

    Article  CAS  PubMed  Google Scholar 

  57. Svircevic V, Passier MM, Nierich AP, van Dijk D, Kalkman CJ, van der Heijden GJ. Epidural analgesia for cardiac surgery. Cochrane Database Syst Rev. 2013;6:CD006715.

    Google Scholar 

  58. Hughes MJ, Ventham NT, McNally S, Harrison E, Wigmore S. Analgesia after open abdominal surgery in the setting of enhanced recovery surgery: a systematic review and meta-analysis. JAMA Surg. 2014;149(12):1224–30.

    Article  PubMed  Google Scholar 

  59. Sagiroglu G, Meydan B, Copuroglu E, Baysal A, Yoruk Y, Altemur Karamustafaoglu Y, Huseyin S. A comparison of thoracic or lumbar patient-controlled epidural analgesia methods after thoracic surgery. World J Surg Oncol. 2014;12(1):96.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Beattie WS, Badner NH, Choi P. Epidural analgesia reduces postoperative myocardial infarction: a meta-analysis. Anesth Analg. 2001;93(4):853–8.

    Article  CAS  PubMed  Google Scholar 

  61. Popping DM, Van Aken HK, Brodner G, Wenk M. It is not the epidural that is dangerous, but the person who gives it (letter). Br J Anaesth. 2014;112(2):392–3.

    Article  CAS  PubMed  Google Scholar 

  62. Thompson DA, Makary MA, Dorman T, Pronovost PJ. Clinical and economic outcomes of hospital acquired pneumonia in intra-abdominal surgery patients. Ann Surg. 2006;243(4):547–52.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Ledowski T, Paech MJ, Patel B, Schug SA. Bronchial mucus transport velocity in patients receiving propofol and remifentanil versus sevoflurane and remifentanil anesthesia. Anesth Analg. 2006;102(5):1427–30.

    Article  CAS  PubMed  Google Scholar 

  64. Manikian B, Cantineau JP, Bertrand M, Kieffer E, Sartene R, Viars P. Improvement of diaphragmatic function by a thoracic extradural block after upper abdominal surgery. Anesthesiology. 1988;68(3):379–86.

    Article  CAS  PubMed  Google Scholar 

  65. Peyton PJ, Myles PS, Silbert BS, Rigg JA, Jamrozik K, Parsons R. Perioperative epidural analgesia and outcome after major abdominal surgery in high-risk patients. Anesth Analg. 2003;96(2):548.

    PubMed  Google Scholar 

  66. N S, Yuzbasioglu MF, Oksuz H, Yildiz H, Dogan Z, Bulbuloglu E, Goksu M, Gisi G. Effects of epidural-and-general anesthesia combined versus general anesthesia alone on femoral venous flow during laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A. 2010;20(3):219–23.

    Article  Google Scholar 

  67. Gan TJ, Robinson SB, Oderda GM, Scranton R, Pepin J, Ramamoorthy S. Impact of postsurgical opioid use and ileus on economic outcomes in gastrointestinal surgeries. Curr Med Res Opin. 2015;31(4):677–86.

    Article  CAS  PubMed  Google Scholar 

  68. Kuruba R, Fayard N, Snyder D. Epidural analgesia and laparoscopic technique do not reduce incidence of prolonged ileus in elective colon resections. Am J Surg. 2012;204(5):613–8.

    Article  PubMed  Google Scholar 

  69. Barletta JF, Asgeirsson T, Senagore AJ. Influence of intravenous opioid dose on postoperative ileus. Ann Pharmacother. 2011;45(7–8):916–23.

    Article  CAS  PubMed  Google Scholar 

  70. Guay J, Nishimori M, Kopp S. Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery. Cochrane Database Syst Rev. 2016;7:CD001893.

    PubMed  Google Scholar 

  71. Khan SA, Khokhar HA, Nasr ARH, Carton E, El-Masry S. Effect of epidural analgesia on bowel function in laparoscopic colorectal surgery: a systematic review and meta-analysis. Surg Endosc. 2013;27(7):2581–91.

    Article  PubMed  Google Scholar 

  72. Kamiński JP, Pai A, Ailabouni L, Park JJ, Marecik SJ, Prasad LM, et al. Role of epidural and patient-controlled analgesia in site-specific laparoscopic colorectal surgery. JSLS. 2014;18(4):e2014.00207.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology. 2006;105(4):660–4.

    Article  PubMed  Google Scholar 

  74. JG HILLER, MB HACKING, EK LINK, KL WESSELS, BJ RIEDEL. Perioperative epidural analgesia reduces cancer recurrence after gastro-oesophageal surgery. Acta Anaesthesiol Scand. 2014;58(3):281–90.

    Article  Google Scholar 

  75. Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY. Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res. 2002;62:4491–8.

    CAS  PubMed  Google Scholar 

  76. Koltun WA, Bloomer MM, Tilberg AF, Seaton JF. Awake epidural anesthesia is associated with improved natural killer cell cytotoxicity and a reduced stress response. Am J Surg. 1996;171:68–73.

    Article  CAS  PubMed  Google Scholar 

  77. Mao L, Lin S, Lin J. The effects of anesthetics on tumor progression. Int J Physiol Pathophysiol Pharmacol. 2013;5(1):1–10.

    PubMed  PubMed Central  Google Scholar 

  78. Lirk P, Hollmann MW, Fleischer M, Weber NC, Fiegl H. Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro. Br J Anaesth. 2014;113(suppl 1):i32–8.

    Article  CAS  PubMed  Google Scholar 

  79. Sun Y, Li T, Gan TJ. The effects of perioperative regional anesthesia and analgesia on cancer recurrence and survival after oncology surgery. Reg Anesth Pain Med. 2015;40(5):589–98.

    Article  CAS  PubMed  Google Scholar 

  80. Cakmakkaya OS, Kolodzie K, Apfel CC. Anaesthetic techniques for risk of malignant tumour recurrence. Cochrane Database Syst Rev. 2014;11:Art. No.: CD008877.

    Google Scholar 

  81. Day A, Smith R, Jourdan I, Fawcett W, Scott M, Rockall T. Retrospective analysis of the effect of postoperative analgesia on survival in patients after laparoscopic resection of colorectal cancer. Br J Anaesth. 2012;109(2):185–90.

    Article  CAS  PubMed  Google Scholar 

  82. Cummings KC, Xu F, Cummings LC, Cooper GS. A comparison of epidural analgesia and traditional pain management effects on survival and cancer recurrence after colectomy: a population-based study. Anesthesiology. 2012;116(4):797–806.

    Article  CAS  PubMed  Google Scholar 

  83. Wantman A, Hancox N, Howell PR. Techniques for identifying the epidural space: a survey of practice amongst anaesthetists in the UK. Anaesthesia. 2006;61(4):370–5.

    Article  CAS  PubMed  Google Scholar 

  84. Schier R, Guerra D, Aguilar J, Pratt GF, Hernandez M, Boddu K, et al. Epidural space identification: a meta-analysis of complications after air versus liquid as the medium for loss of resistance. Anesth Analg. 2009;109(6):2012–21.

    Article  PubMed  Google Scholar 

  85. Antibas PL, do Nascimento Junior P, Braz LG, Vitor Pereira Doles J, NSP M, Dib El R. Air versus saline in the loss of resistance technique for identification of the epidural space. Cochrane Database Syst Rev. 2014;7:CD008938.

    Google Scholar 

  86. Hermanides J, Hollmann MW, Stevens MF, Lirk P. Failed epidural: causes and management. Br J Anaesth. 2012 Jul;109(2):144–54.

    Article  CAS  PubMed  Google Scholar 

  87. Todorov L, VadeBoncouer T. Etiology and use of the “hanging drop” technique: a review. Pain Res Treat. 2014;2014(4):1–10.

    Google Scholar 

  88. Bonica JJ, Backup PH, Anderson CE, HADFIELD D, Crepps WF, Monk BF. Peridural block: analysis of 3,637 cases and a review. Anesthesiology. 1957;18(5):723–84.

    Article  CAS  PubMed  Google Scholar 

  89. Hoffmann VL, Vercauteren MP, Vreugde JP, Hans GH, Coppejans HC, Adriaensen HA. Posterior epidural space depth: safety of the loss of resistance and hanging drop techniques. Br J Anaesth. 1999;83(5):807–9.

    Article  CAS  PubMed  Google Scholar 

  90. Stone PA, Kilpatrick AW, Thorburn J. Posture and epidural catheter insertion. The relationship between skill, experience and maternal posture on the outcome of epidural catheter insertion. Anaesthesia. 1990;45(11):920–3.

    Article  CAS  PubMed  Google Scholar 

  91. Hamilton CL, Riley ET, Cohen SE. Changes in the position of epidural catheters associated with patient movement. Anesthesiology. 1997;86(4):778–84. discussion 29A

    Article  CAS  PubMed  Google Scholar 

  92. Mhyre JM, Greenfield MLVH, Tsen LC, Polley LS. A systematic review of randomized controlled trials that evaluate strategies to avoid epidural vein cannulation during obstetric epidural catheter placement. Anesth Analg. 2009;108(4):1232–42.

    Article  PubMed  Google Scholar 

  93. Podder S, Kumar N, Yaddanapudi LN, Chari P. Paramedian lumbar epidural catheter insertion with patients in the sitting position is equally successful in the flexed and unflexed spine. Anesth Analg. 2002;99:1829–32.

    Google Scholar 

  94. Leeda M, Stienstra R, Arbous MS, et al. Lumbar epidural catheter insertion: the midline vs. the paramedian approach. Eur J Anaesthesiol. 2005;22:839–42.

    Article  CAS  PubMed  Google Scholar 

  95. Visser WA, Liem TH, van Egmond J, Gielen MJM. Extension of sensory blockade after thoracic administration of a test dose of lidocaine at three different levels. Anesth Analg. 1998;86:332–5.

    CAS  PubMed  Google Scholar 

  96. Yokoyama M, Hanazaki M, Fujii H, Mizobuchi S, Nakatsuka H, Takahashi T, Matsumi M, Takeuchi M, Morita K. Correlation between the distribution of contrast medium and the extent of blockade during epidural anesthesia. Anesthesiology. 2004;100:1504–10.

    Article  PubMed  Google Scholar 

  97. Shaikh F, Brzezinski J, Alexander S, Arzola C, Carvalho JCA, Beyene J, et al. Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis. BMJ. 2013;346:f1720.

    Article  PubMed  Google Scholar 

  98. Scott DA, Chamley DM, Mooney PH. Epidural ropivacaine infusion for postoperative analgesia after major lower abdominal surgery—a dose finding study. Anesth Analg. 1995;81:982–6.

    CAS  PubMed  Google Scholar 

  99. Manion SC, Brennan TJ. Thoracic epidural analgesia and acute pain management. Anesthesiology. 2011;115(1):181–8.

    Article  PubMed  Google Scholar 

  100. Hjortsø NC, Lund C, Mogensen T, Bigler D, Kehlet H. Epidural morphine improves pain relief and maintains sensory analgesia during continuous epidural bupivacaine after abdominal surgery. Anesth Analg. 1986;65(10):1033–6.

    PubMed  Google Scholar 

  101. Bromage PR, Camporesi E, Chestnut D. Epidural narcotics for postoperative analgesia. Anesth Analg. 1980;59(7):473–80.

    Article  CAS  PubMed  Google Scholar 

  102. Ummenhofer WC, Arends RH. Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. Anesthesiology. 2000;92:739–53.

    Article  CAS  PubMed  Google Scholar 

  103. Carvalho B. Respiratory depression after neuraxial opioids in the obstetric setting. Anesth Analg. 2008;107(3):956–61.

    Article  PubMed  Google Scholar 

  104. Kabon B, Fleischmann E, Treschan T, Taguchi A, Kapral S, Kurz A. Thoracic epidural anesthesia increases tissue oxygenation during major abdominal surgery. Anesth Analg. 2003;97(6):1812–7.

    Article  PubMed  Google Scholar 

  105. Youssef N, Orlov D, Alie T, Chong M, Cheng J, Thabane L, et al. What epidural opioid results in the best analgesia outcomes and fewest side effects after surgery? Anesth Analg. 2014;119(4):965–77.

    Article  CAS  PubMed  Google Scholar 

  106. Capogna G, Camorcia M, Stirparo S, Farcomeni A. Programmed intermittent epidural bolus versus continuous epidural infusion for labor analgesia. Anesth Analg. 2011;113(4):826–31.

    Article  PubMed  Google Scholar 

  107. Vallejo MC, Ramesh V, Phelps AL, Sah N. Epidural labour analgesia: continuous infusion versus patient-controlled epidural analgesia with background infusion versus without background infusion. J Pain. 2007;8:970–5.

    Article  PubMed  Google Scholar 

  108. Arendt K, Segal S. Why epidurals do not always work. Rev Obstet Gynecol. 2008;1(2):49–55.

    PubMed  PubMed Central  Google Scholar 

  109. Hogan QH. Epidural anatomy: new observations. Can J Anesth. 1998;45:R40–8.

    Article  CAS  PubMed  Google Scholar 

  110. Motamed C, Farhat F, R m rand F, St phanazzi J, Laplanche AS, Jayr C. An analysis of postoperative epidural analgesia failure by computed tomography epidurography. Anesth Analg. 2006;103(4):1026–32.

    Article  CAS  PubMed  Google Scholar 

  111. Afshan G, Chohan U, Khan FA, Chaudhry N, Khan ZE, Khan AA. Appropriate length of epidural catheter in the epidural space for postoperative analgesia: evaluation by epidurography. Anaesthesia. 2011;66(10):913–8.

    Article  CAS  PubMed  Google Scholar 

  112. Kinsella SM. A prospective audit of regional anaesthesia failure in 5080 Caesarean sections. Anaesthesia. 2008;63:822–32.

    Article  CAS  PubMed  Google Scholar 

  113. Sugimoto M, Nesbit L, Barton JG, Traverso LW. Epidural anesthesia dysfunction is associated with postoperative complications after pancreatectomy. J Hepatobiliary Pancreat Sci. 2016;23(2):102–9.

    Article  PubMed  Google Scholar 

  114. Pan PH, Bogard TD, Owen MD. Incidence and characteristics of failures in obstetric neuraxial analgesia and anesthesia: a retrospective analysis of 19,259 deliveries. Int J Obstet Anesth. 2004;13(4):227–33.

    Article  CAS  PubMed  Google Scholar 

  115. Kini SP. The impact of pruritus on quality of life. Arch Dermatol. 2011;147(10):1153.

    Article  PubMed  Google Scholar 

  116. Cook TM, Counsell D, Wildsmith JAW, On Behalf of The Royal College of Anaesthetists Third National Audit Project. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. Br J Anaesth. 2009;102(2):179–90. https://academic.oup.com/bja/article-lookup/doi/10.1093/bja/aen360

    Article  CAS  PubMed  Google Scholar 

  117. Horlocker TT. Regional anaesthesia in the patient receiving antithrombotic and antiplatelet therapy. Br J Anaesth. 2011;107(Suppl 1):i96–106.

    Article  CAS  PubMed  Google Scholar 

  118. Siniscalchi A. Thoracic epidural anesthesia: effects on splanchnic circulation and implications in anesthesia and intensive care. World J Crit Care Med. 2015;4(1):89.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Gould T, Grace K, Thome G. Effect of thoracic epidural anaesthesia on colonic blood flow. Br J Anaesth. 2002;89(3):446–51.

    Article  CAS  PubMed  Google Scholar 

  120. Piccioni F, Mariani L, Negri M, Casiraghi C, Belli F, Leo E, et al. Epidural analgesia does not influence anastomotic leakage incidence after open colorectal surgery for cancer: a retrospective study on 1,474 patients. J Surg Oncol. 2015;112(2):225–30.

    Article  CAS  PubMed  Google Scholar 

  121. Lovely JK, Maxson PM, Jacob AK, Cima RR, Horlocker TT, Hebl JR, et al. Case-matched series of enhanced versus standard recovery pathway in minimally invasive colorectal surgery. Br J Surg. 2011;99(1):120–6.

    Article  PubMed  Google Scholar 

  122. Ntinas A, Kardassis D, Konstantinopoulos I, Kottos P, Manias A, Kyritsi M, et al. Duration of the thoracic epidural catheter in a fast-track recovery protocol may decrease the length of stay after a major hepatectomy: a case control study. Int J Surg. 2013;11(9):882–5.

    Article  CAS  PubMed  Google Scholar 

  123. Ahmed J, Lim M, Khan S, McNaught C, MacFie J. Predictors of length of stay in patients having elective colorectal surgery within an enhanced recovery protocol. Int J Surg. 2010;8(8):628–32.

    Article  PubMed  Google Scholar 

  124. Borzellino G, Francis NK, Chapuis O, Krastinova E, VXR D, Genna M. Review article. Role of epidural analgesia within an ERAS program after laparoscopic colorectal surgery: a review and meta-analysis of randomised controlled studies. Surg Res Pract. 2016;2016:7543684.

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan Antrobus .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Antrobus, J. (2018). Thoracic Epidural Analgesia. In: Krige, A., Scott, M. (eds) Analgesia in Major Abdominal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-94482-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-94482-1_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94480-7

  • Online ISBN: 978-3-319-94482-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics