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Copper and Bacteria pp 21–48Cite as

Copper Homeostasis in Gram-Positive Bacteria

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Abstract

Copper homeostasis in Gram-positive bacteria essentially requires three components: a copper exporting ATPase (founding member CopA), a copper chaperone (founding member CopZ), and a copper-responsive regulator (founding member CopY) which regulates the expression of these functions. GSH works as a back-up protective system. These four components are also part of the more complex copper homeostatic mechanism of Gram-negative organisms, discussed in Chap. 4, but will only be discussed in detail in this Chapter. Copper reduction at the plasma membrane, which is specific to Gram-positive bacteria will also be discussed here. Finally, copper regulons, which are apparently specific to Firmicutes, are presented. Most of the findings described here derive from Enterococcus hirae and L. lactis, but other organisms are considered as necessary.

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    Marc Solioz

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Solioz, M. (2018). Copper Homeostasis in Gram-Positive Bacteria. In: Copper and Bacteria. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-94439-5_3

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