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Adult Critical Care Medicine pp 1–24Cite as

Management of Intracranial Hypertension and Status Epilepticus

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Abstract

Intracranial hypertension, also known as elevated intracranial pressure, and status epilepticus are neurologic emergencies encountered in critically ill patients. Prompt recognition and treatment is imperative to prevent significant and potentially permanent brain injury or even death. Here we review management algorithms for the treatment of these patients.

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References

  1. Lozier AP, Sciacca RR, Romagnoli MF, et al. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery. 2002;51:170–81.

    Article  Google Scholar 

  2. Bekar A, Dogan S, Abas F, et al. Risk factors and complications of intracranial pressure monitoring with a fiberoptic device. J Clin Neurosci. 2009;16:236–40.

    Article  CAS  Google Scholar 

  3. Fried HI, Nathan BR, Rowe AS, et al. The insertion and management of external ventricular devices: an evidence-based consensus statement. Neurocrit Care. 2016;24:61–81.

    Article  Google Scholar 

  4. Muralidharan R. External ventricular drains: management and complications. Surg Neurol Int. 2015;6(Suppl 6):S271–4.

    Article  Google Scholar 

  5. Muench E, et al. Effects of positive end-expiratory pressure on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation. Crit Care Med. 2005;33:2367–72.

    Article  Google Scholar 

  6. Prabhakar H, Sandhu K, Bhagat H, et al. Current concepts of optimal cerebral perfusion pressure in traumatic brain injury. J Anaesthesiol Clin Pharmacol. 2014;30:318–27.

    Article  Google Scholar 

  7. Kamel H, Navi BB, Nakagawa K, et al. Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials. Crit Care Med. 2011;39:554–9.

    Article  CAS  Google Scholar 

  8. Diringer MN. New trends in hyperosmolar therapy? Curr Opin Crit Care. 2013;19:77–82.

    Article  Google Scholar 

  9. Aiyagari V, Deibert E, Diringer MN. Hypernatremia in the neurologic intensive care unit: how high is too high? J Crit Care. 2006;21:163–72.

    Article  Google Scholar 

  10. Garcia-Morales EJ, Cariappa R, Parvin CA, et al. Osmole gap in neurologic-neurosurgical intensive care unit: its normal value, calculation, and relationship with mannitol serum concentrations. Crit Care Med. 2004;32:986–91.

    Article  Google Scholar 

  11. Greer DM, Funk SE, Reaven NL, et al. Impact of fever on outcome in patients with stroke and neurologic injury. Stroke. 2008;39:3029–35.

    Article  Google Scholar 

  12. Andrews PJD, Sinclair HL, Rodriguez A, et al. Hypothermia for intracranial hypertension after traumatic brain injury. N Engl J Med. 2015;373:2403–12.

    Article  CAS  Google Scholar 

  13. Choi HA, Ko SB, Presciutti M, et al. Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol. Neurocrit Care. 2011;14(3):389–94.

    Article  Google Scholar 

  14. Nordstrom CH, Messeter K, Sundbarg G, et al. Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions. J Neurosurg. 1988;68:424–31.

    Article  CAS  Google Scholar 

  15. Kim Y, Park S, Nam T, et al. The effect of barbiturate coma therapy for patients with severe intracranial hypertension: a 10-year experience. J Korean Neurosurg Soc. 2008;44:141–5.

    Article  Google Scholar 

  16. Shneker BF, Fountain NB. Assessment of acute morbidity and mortality of non-convulsive status epilepticus. Neurology. 2003;61:1066–73.

    Article  Google Scholar 

  17. DeLorenzo RJ, Hauser WA, Towne AR, et al. A prospective, population based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology. 1996;46:1029–35.

    Article  CAS  Google Scholar 

  18. Oddo M, Carrera E, Claassen J, et al. Continuous electroencephalography in the medical intensive care unit. Crit Care Med. 2009;37:2051–6.

    Article  Google Scholar 

  19. Kurtz P, Gaspard N, Wahl AS, et al. Continuous electroencephalography in the surgical intensive care unit. Intensive Care Med. 2014;40:228–34.

    Article  Google Scholar 

  20. Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology. 1993;43:483–8.

    Article  CAS  Google Scholar 

  21. Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001;345:631–7.

    Article  CAS  Google Scholar 

  22. Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans affairs status epilepticus cooperative study group. N Engl J Med. 1998;339:792–8.

    Article  CAS  Google Scholar 

  23. Silbergleit R, Durkalski V, Lowenstein DH, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366:591–600.

    Article  CAS  Google Scholar 

  24. Glauser T, Shinnar S, Gloss D, et al. Evidenced based guideline: treatment of convulsive status epilepticus in children and adults: report of the guideline committee of the American Epilepsy Society. Epilepsy Curr. 2016;16:48–61.

    Article  Google Scholar 

  25. Gilad R, Izkovitz N, Dabby R, et al. Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. Acta Neurol Scand. 2008;118:296–300.

    Article  CAS  Google Scholar 

  26. Misra UK, Kalita J, Patel R. Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology. 2006;67:340–2.

    Article  CAS  Google Scholar 

  27. Limdi NA, Faught E. The safety of rapid valproic acid infusions. Epilespia. 2000;41:1342–5.

    Article  CAS  Google Scholar 

  28. Berning S, Boesebeck F, van Baalen K, et al. Intravenous levetiracetam as treatment for status epilepticus. J Neurol. 2009;256:1634–42.

    Article  CAS  Google Scholar 

  29. Corry JJ, Dhar R, Murphy T, et al. Hypothermia for refractory status epilepticus. Neurocrit Care. 2008;9:189–97.

    Article  CAS  Google Scholar 

  30. Nardone R, Brigo F, Trinka E. Acute symptomatic seizures caused by electrolyte disturbances. J Clin Neurol. 2016;12:21–33.

    Article  Google Scholar 

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Authors and Affiliations

  1. University of Rochester Medical Center, Rochester, NY, USA

    Christopher Begley & Debra Roberts

Authors
  1. Christopher Begley
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  2. Debra Roberts
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Corresponding author

Correspondence to Debra Roberts .

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Editors and Affiliations

  1. Newark, NJ, USA

    Jennifer A. LaRosa

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Begley, C., Roberts, D. (2019). Management of Intracranial Hypertension and Status Epilepticus. In: LaRosa, J. (eds) Adult Critical Care Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-94424-1_1

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  • DOI: https://doi.org/10.1007/978-3-319-94424-1_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94423-4

  • Online ISBN: 978-3-319-94424-1

  • eBook Packages: MedicineMedicine (R0)

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