Advertisement

A Cryotherapeutic Device for Preventing Nail Toxicity During Chemotherapy: Comparison of Three Cooling Strategies

Conference paper
  • 632 Downloads
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 779)

Abstract

Onycholysis is a form of nail toxicity where the nail detaches from the nail bed. This medical condition is reported to appear with up to 44% of the patients undergoing a taxanes based chemotherapy. Frozen gloves can be effective in preventing nail toxicity as they enable cold-induced vasoconstriction (CIVC), or reduction of blood flow, and therefore limits the transport of chemotherapeutic agents towards the nail bed. Unfortunately, the use of frozen gloves also results in cold-induced vasodilation (CIVD), which increases blood flow and reduces the effectiveness of the preventive treatment. Moreover, the gloves induce pain and additional distress during a cancer treatment. The objective of this article is to examine the usefulness of an active local cooling device for controlling blood flow in the fingertips and reducing CIVD, while limiting pain and discomfort. Three different cooling strategies are evaluated for comparing their cooling effectiveness.

Keywords

Onycholysis Chemotherapy Cold-Induced Vasodilation Pulsed cooling Cryotherapy Nail bed toxicity 

References

  1. 1.
    Minisini, A.M., et al.: Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann. Oncol. 14(2), 333–337 (2003)CrossRefGoogle Scholar
  2. 2.
    Bladt, L., et al.: Cold-induced vasoconstriction for preventing onycholysis during cancer treatment. Extrem. Physiol. Med. 4(1), A60 (2015)CrossRefGoogle Scholar
  3. 3.
    Hussain, S., Anderson, D.N., Salvatti, M.E., Adamson, B., McManus, M., Braverman, A.S.: Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature. Cancer 88(10), 2367–2371 (2000)CrossRefGoogle Scholar
  4. 4.
    Robert, C., et al.: Nail toxicities induced by systemic anticancer treatments. Lancet Oncol. 16(4), e181–e189 (2015)CrossRefGoogle Scholar
  5. 5.
    Kadakia, K.C., Rozell, S.A., Butala, A.A., Loprinzi, C.L.: Supportive cryotherapy: a review from head to toe. J. Pain Symptom Manage. 47(6), 1100–1115 (2014)CrossRefGoogle Scholar
  6. 6.
    Tyler, C.J., Reeve, T., Cheung, S.S.: Cold-induced vasodilation during single digit immersion in 0°C and 8°C water in men and women. PLoS ONE 10(4), 1–13 (2015)CrossRefGoogle Scholar
  7. 7.
    Daanen, H.A.M.: Finger cold-induced vasodilation: a review. Eur. J. Appl. Physiol. 89(5), 411–426 (2003)CrossRefGoogle Scholar
  8. 8.
    Scotté, F., et al.: Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. J. Clin. Oncol. 23(19), 4424–4429 (2005)CrossRefGoogle Scholar
  9. 9.
    Steckel, J., et al.: A research platform using active local cooling directed at minimizing the blood flow in human fingers. In: Proceedings of the ICTs Improving Patients Rehabilitation Research Techniques, pp. 81–84 (2013)Google Scholar
  10. 10.
    Scotté, F., et al.: Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer 112(7), 1625–1631 (2008)CrossRefGoogle Scholar
  11. 11.
    Can, G., Aydiner, A., Cavdar, I.: Taxane-induced nail changes: predictors and efficacy of the use of frozen gloves and socks in the prevention of nail toxicity. Eur. J. Oncol. Nurs. 16(3), 270–275 (2012)CrossRefGoogle Scholar
  12. 12.
    Sawada, S., Araki, S., Yokoyama, K.: Changes in cold-induced vasodilatation, pain and cold sensation in fingers caused by repeated finger cooling in a cool environment. Ind. Health 38, 79–86 (2000)CrossRefGoogle Scholar
  13. 13.
    D’Haene, M., Youssef, A., De Bruyne, G., Aerts, J.-M.: Modelling and controlling blood flow by active cooling of the fingers to prevent nail toxicity, Thesis. KU Leuven, Belgium, November, p. 89 (2015)Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department Product DevelopmentUniversity of AntwerpAntwerpBelgium

Personalised recommendations