Dengue: A Silent Killer, a Worldwide Threat

Part of the Parasitology Research Monographs book series (Parasitology Res. Monogr., volume 10)


Nowadays, the timely and effective management of mosquito-borne diseases is a crucial public health challenge to deal with. Dengue is an emerging mosquito-borne infectious disease transmitted by Aedes species. Around 3.9 billion people from more than 128 countries were affected by dengue fever. Recent research outlined that dengue can damage the platelet, disrupting the endothelium bed and provoking immune responses, resulting in severe illness. The illness extends to other vital organs, resulting in homeostasis imbalance. Currently, no vaccines, drugs, or vector control measures showed full efficacy to prevent or manage this arbovirus threat. The present chapter discussed our knowledge about dengue basic biology, epidemiology, clinical aspects, and vector control measures. In the final section, several issues to be addressed by further research are critically analyzed.


Aedes aegypti Aedes albopictus Arbovirus Culicidae Epidemiology Invasive mosquito species Pesticides Vaccine 



This work was supported by the Putra Grant, Universiti Putra Malaysia, Malaysia (9470200); the authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding of this research through the Research Group Project No. RG-1435-065.

Conflict of Interest: The authors declare that there is no conflict of interest regarding the publication of this study.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical Microbiology and ParasitologyUniversiti Putra MalaysiaSerdangMalaysia
  2. 2.Department of Biomedical ScienceUniversiti Putra MalaysiaSerdangMalaysia
  3. 3.Department of Clinical Laboratory Sciences, College of Applied Medical SciencesJouf UniversitySakakaSaudi Arabia
  4. 4.Department of Chemical and Materials EngineeringNational Central UniversityTaoyuanTaiwan
  5. 5.Department of ReproductionNational Research Institute for Child Health and DevelopmentTokyoJapan
  6. 6.Department of Botany and MicrobiologyKing Saud UniversityRiyadhSaudi Arabia
  7. 7.Department of Agriculture, Food and EnvironmentUniversity of PisaPisaItaly
  8. 8.The BioRobotics Institute, Sant’Anna School of Advanced StudiesPisaItaly

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