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Hematologic Challenges in the Critically Ill pp 363–389Cite as

Intravenous Oxygen Therapeutics: A Revolution in Medicine Yet to Be Realized?

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Abstract

Intravenous fluids have been categorized as colloids and crystalloids, but missing from both is the ability to carry enhanced oxygen levels. Medicine has pursued an oxygen therapeutic since the early 1930s with actually some spotty points of success. There are places in the world today that such agents are available, but they have not realized their potential. Two distinctly different pharmaceutical approaches are under accelerated development: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon (PFC) preparations. If fully developed either or both would represent revolutions in medicine with far-reaching and game-changing treatment options. This chapter will explore assumptions about oxygen carrying and delivery made by medicine that to some degree have hindered the development of these compounds. The history to this point is outlined with a careful look forward into perhaps what is to come.

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Authors and Affiliations

  1. Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA

    Bruce D. Spiess MD, FAHA

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  1. Bruce D. Spiess MD, FAHA
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Correspondence to Bruce D. Spiess MD, FAHA .

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  1. Department of Anesthesiology, Critical Care and Hyperbaric Medicine, Team Health Research Institute, Englewood, NJ, USA

    Aryeh Shander

  2. Department of Critical Care Medicine, Geisinger Health System, Danville, PA, USA

    Howard L. Corwin

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Spiess, B.D. (2018). Intravenous Oxygen Therapeutics: A Revolution in Medicine Yet to Be Realized?. In: Shander, A., Corwin, H. (eds) Hematologic Challenges in the Critically Ill. Springer, Cham. https://doi.org/10.1007/978-3-319-93572-0_19

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  • DOI: https://doi.org/10.1007/978-3-319-93572-0_19

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