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The Mesangial Cell in Diabetic Nephropathy

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Diabetic Nephropathy

Abstract

The mesangial cell plays a crucial role in the formation and maintenance of the glomerular capillary tuft and in the homeostasis of the mesangial matrix. Expansion of the mesangium, both diffuse and nodular, is a hallmark of DN. Numerous studies have shown adverse responses of the mesangial cell to injuries related to metabolic and hemodynamic effects of diabetes, including high glucose, insulin dysregulation, mechanical stress, dyslipidemia, and profibrotic growth factors. Their pivotal role in the development and progression of DN makes mesangial cells an interesting target for treatment, but this will be challenging because of the lack of specific markers.

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Authors and Affiliations

  1. Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

    Tri Q. Nguyen & Roel Goldschmeding

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  1. Tri Q. Nguyen
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  2. Roel Goldschmeding
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Correspondence to Tri Q. Nguyen .

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Editors and Affiliations

  1. Department of Pathology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

    Joris J. Roelofs

  2. Department of Internal Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

    Liffert Vogt

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Nguyen, T.Q., Goldschmeding, R. (2019). The Mesangial Cell in Diabetic Nephropathy. In: Roelofs, J., Vogt, L. (eds) Diabetic Nephropathy. Springer, Cham. https://doi.org/10.1007/978-3-319-93521-8_9

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  • DOI: https://doi.org/10.1007/978-3-319-93521-8_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-93520-1

  • Online ISBN: 978-3-319-93521-8

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