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Cardiovascular Complications in Cancer Therapy pp 45–55Cite as

Cardiovascular Damage Induced by Anti-BCR-ABL TKIs

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Abstract

Anti-BCR-ABL TKIs (tyrosine kinase inhibitors) are drugs that inhibit BCR ABL tyrosine. They are used especially in the treatment of hematological cancer and gastrointestinal stromal tumors (GIST). Anti-BCR-ABL TKIs include first (imatinib), second (nilotinib, dasatinib, bosutinib) and third-generation drugs (ponatinib). Especially second- and third-generation drugs can cause cardiovascular complications such as arterial thrombosis, myocardial ischemia, peripheral arterial diseases, QTc prolongation, and pulmonary hypertension. Nilotinib and ponatinib can cause thrombotic arterial events with various mechanisms. Particularly dasatinib can cause pulmonary hypertension. Compared to conventional chemotherapy, myocardial dysfunction was found in a smaller number of cases. In this chapter, we will illustrate cardiovascular adverse effects induced by anti-BCR-ABL TKIs, the main mechanisms that could explain such effects, and the influence played by cardiovascular risk factors. It is essential for both cardiologists and oncologists to know these issues in order to develop appropriate monitoring and apply preventive strategies to avoid the occurrence of toxicity and the need of any premature interruption of the antineoplastic treatment.

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Authors and Affiliations

  1. Division of Cardiology, Biomedical Department of Internal Medicine and Specialities (DIBIMIS), University of Palermo, Palermo, Italy

    Giuseppina Novo & Daniela Di Lisi

  2. Department of Cardiology, University Hospital Santa Maria, CHLN University of Lisbon, Lisbon, Portugal

    Manuela Fiuza & Fausto J. Pinto

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  1. Giuseppina Novo
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  2. Daniela Di Lisi
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  3. Manuela Fiuza
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  4. Fausto J. Pinto
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Editors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy

    Antonio Russo

  2. University of Palermo, School of Medicine, Palermo, Italy

    Giuseppina Novo

  3. Department of Cardiology, University of Liège, Liege, Belgium

    Patrizio Lancellotti

  4. Temple University College of Science and Technology, Philadelphia, PA, USA

    Antonio Giordano

  5. Cardiology Department, University of Lisbon, Lisbon, Portugal

    Fausto J. Pinto

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Novo, G., Di Lisi, D., Fiuza, M., Pinto, F.J. (2019). Cardiovascular Damage Induced by Anti-BCR-ABL TKIs. In: Russo, A., Novo, G., Lancellotti, P., Giordano, A., Pinto, F. (eds) Cardiovascular Complications in Cancer Therapy. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-93402-0_6

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