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Cardiovascular Damage Induced by Radiotherapy

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Cardiovascular Complications in Cancer Therapy

Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Radiotherapy is a fundamental therapeutic aid that in recent years has contributed significantly to improve the prognosis of cancer patients. Despite its great effectiveness, it can cause a wide spectrum of toxic effects. Among these, cardiovascular toxicity is very relevant, and it can occur even many years after the termination of treatment. The concomitant use of radiotherapy with other antineoplastic drugs, including new-generation tyrosine-kinase inhibitors or immunotherapy, can enhance its cardiotoxic effects. It is fundamental to know the cardiovascular toxic effects that are potentially linked to radiotherapy (RIHD: radiation-induced heart damage), to monitor patients who underwent radiotherapy in order to prevent their occurrence and to early detect and treat patients eventually experiencing this complications. In this chapter, we will review the main clinical conditions which can affect the cardiovascular system after radiotherapy, trying to provide some suggestions about the management of the cardiologic patient at risk or burdened by RIHD.

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Authors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy

    Antonio Galvano & Antonio Russo

  2. Division of Cardiology, Biomedical Department of Internal Medicine and Specialities (DIBIMIS), University of Palermo, Palermo, Italy

    Giuseppina Novo

  3. Department of Systems Medicine, Medical Oncology, Policlinico Tor Vergata Biospecimen Cancer Repository, University of Rome Tor Vergata, Rome, Italy

    Mario Roselli

  4. Department of Biology, College of Science and Technology, Temple University, Sbarro Health Research Organization, Inc., Philadelphia, PA, USA

    Antonio Giordano

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  1. Antonio Galvano
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  3. Mario Roselli
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  4. Antonio Giordano
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  5. Antonio Russo
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Correspondence to Giuseppina Novo .

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Editors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy

    Antonio Russo

  2. University of Palermo, School of Medicine, Palermo, Italy

    Giuseppina Novo

  3. Department of Cardiology, University of Liège, Liege, Belgium

    Patrizio Lancellotti

  4. Temple University College of Science and Technology, Philadelphia, PA, USA

    Antonio Giordano

  5. Cardiology Department, University of Lisbon, Lisbon, Portugal

    Fausto J. Pinto

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Galvano, A., Novo, G., Roselli, M., Giordano, A., Russo, A. (2019). Cardiovascular Damage Induced by Radiotherapy. In: Russo, A., Novo, G., Lancellotti, P., Giordano, A., Pinto, F. (eds) Cardiovascular Complications in Cancer Therapy. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-93402-0_4

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