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General Aspects of Pathophysiology, Diagnosis, and Treatment of Sickle Cell Disease

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Proceedings of the 3rd Brazilian Technology Symposium (BTSym 2017)

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Abstract

Since its first report, sickle cell disease (SCD) has attracted the attention of many health professionals and researchers, because its affects about 24.6% of the world population and can cause the death of up to 90% of patients in Africa Sub-Saharan Africa with SCD before 5 years of age. Hemolysis, vaso-occlusive crises, pain crises, chronic inflammation, risk of infarction, thrombosis and stroke are realities constantly faced by the patients affected by this hematologic disorder. The stages of the pathophysiological process, the pathways of activation and molecular aspects are still not fully understood, hence, the patients affected dependent on medical follow-up, periodic examinations, use of medications and even periodic blood transfusions. The objective of the present study was to carry out a bibliographic review aiming at a direct and clear approach to the pathophysiological aspects of the disease discovered and to link them with laboratory tests, drugs used and the recent discoveries made through the research with MicroRNAs.

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Authors and Affiliations

  1. School of Electrical and Computer Engineering (FEEC), University of Campinas – UNICAMP, Av. Albert Einstein - 400, Barão Geraldo, Campinas, SP, Brazil

    Ana Carolina Borges Monteiro, Yuzo Iano & Reinaldo Padilha França

Authors
  1. Ana Carolina Borges Monteiro
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  2. Yuzo Iano
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  3. Reinaldo Padilha França
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Correspondence to Ana Carolina Borges Monteiro .

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Editors and Affiliations

  1. Faculty of Electrical and Computer Engineering, University of Campinas, Campinas, São Paulo, Brazil

    Yuzo Iano

  2. Faculty of Technology, University of Campinas, Campinas, São Paulo, Brazil

    Rangel Arthur

  3. Divisão de Engenharia Eletrônica, Instituto Tecnológico de Aeronáutica (ITA), São José dos Campos, São Paulo, Brazil

    Osamu Saotome

  4. Universidade Federal Fluminense (UFF), Duque de Caxias, Rio de Janeiro, Brazil

    Vania Vieira Estrela

  5. Faculty of Electrical and Computer Engineering, University of Campinas, Campinas, São Paulo, Brazil

    Hermes José Loschi

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Monteiro, A.C.B., Iano, Y., França, R.P. (2019). General Aspects of Pathophysiology, Diagnosis, and Treatment of Sickle Cell Disease. In: Iano, Y., Arthur, R., Saotome, O., Vieira Estrela, V., Loschi, H. (eds) Proceedings of the 3rd Brazilian Technology Symposium. BTSym 2017. Springer, Cham. https://doi.org/10.1007/978-3-319-93112-8_32

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  • DOI: https://doi.org/10.1007/978-3-319-93112-8_32

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-93111-1

  • Online ISBN: 978-3-319-93112-8

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