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Prophylactic Versus Selective Central Neck Dissection in Pediatric Papillary Thyroid Cancer

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Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY))

Abstract

The first case of thyroid carcinoma in a child was described in 1902. Following this, Crile published the first case series of pediatric thyroid cancer in 1959, whereby he characterized pediatric thyroid cancer in 18 children. He noted that pediatric thyroid cancer was more commonly metastatic to cervical lymph nodes and to the lungs than was described in the adult population. Despite finding these cancers to be more aggressive than in adults, only one of the patients died of thyroid cancer and four of them were alive with lung metastases. This publication spawned many subsequent studies confirming these findings. As a result, there has been much debate on the appropriate surgical treatment of thyroid cancer in the pediatric population both with respect to the extent of surgery and the use of radioactive iodine.

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References

  1. Crile G Jr. Carcinoma of the thyroid in children. Ann Surg. 1959;150:959.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Wu XC, et al. Cancer incidence in adolescents and young adults in the United States, 1992-1997. J Adolesc Health. 2003;32(6):405–15.

    Article  PubMed  Google Scholar 

  3. American Cancer Society. Cancer facts & figures 2009. Atlanta: American Cancer Society; 2009.

    Google Scholar 

  4. Waguespack S, et al. In: Bleyer A, et al., editors. Thyroid cancer, in cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival 1975–2000. Bethesda: National Cancer Institute; 2006. p. 143–54.

    Google Scholar 

  5. Hay ID, et al. Long-term outcome in 215 children and adolescents with papillary thyroid cancer treated during 1940 through 2008. World J Surg. 2010;34:1192–202.

    Article  PubMed  Google Scholar 

  6. Grigsby PW, et al. Childhood and adolescent thyroid carcinoma. Cancer. 2002;95:724–9.

    Article  PubMed  Google Scholar 

  7. Jarzab B, et al. Multivariate analysis of prognostic factors for differentiated thyroid carcinoma in children. Eur J Nucl Med. 2000;27:833–41.

    Article  CAS  PubMed  Google Scholar 

  8. Sugino K, et al. Papillary thyroid carcinoma in children and adolescents: long-term follow-up and clinical characteristics. World J Surg. 2015;39(9):2259–65.

    Article  PubMed  Google Scholar 

  9. Dzepina D. Surgical and pathological characteristics of papillary thyroid cancer in children and adolescents. Coll Antropol. 2012;36(suppl 2):39–45.

    PubMed  Google Scholar 

  10. Musacchio MJ, et al. Greater local recurrence occurs with “berry picking” than neck dissection in thyroid cancer. Am Surg. 2003;69(3):191–6. Discussion 196-7.

    PubMed  Google Scholar 

  11. Savio R, et al. The role of a more extensive surgical approach in the initial multimodality management of papillary thyroid cancer in children. J Pediatr Surg. 2005;40(11):1696–700.

    Article  PubMed  Google Scholar 

  12. Marti JL, et al. Increased risk of second primary malignancy in pediatric and young adult patients treated with radioactive iodine for differentiated thyroid cancer. Thyroid. 2015;25(6):681–7.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Sosa JA, et al. Clinical and economic outcomes of thyroid and parathyroid surgery in children. J Clin Endocrinol Metab. 2008;93(8):3058–65.

    Article  CAS  PubMed  Google Scholar 

  14. Tuggle CT, et al. Pediatric endocrine surgery: who is operating on our children? Surgery. 2008;144(6):869–77.

    Article  PubMed  Google Scholar 

  15. Alessandri AJ, et al. Age is the major determinant of recurrence in pediatric differentiated thyroid carcinoma. Med Pediatr Oncol. 2000;35(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  16. Arici C, et al. Differentiated thyroid carcinoma in children and adolescents. Horm Res. 2002;57:153–6.

    PubMed  CAS  Google Scholar 

  17. Borson-Chazot F, et al. Predictive factors for recurrence from a series of 74 children and adolescents with differentiated thyroid cancer. World J Surg. 2004;28:1088–92.

    Article  PubMed  Google Scholar 

  18. Ceccarelli C, et al. Thyroid cancer in children and adolescents. Surgery. 1988;104(6):1143–8.

    PubMed  CAS  Google Scholar 

  19. Danese D. Thyroid carcinoma in children and adolescents. Eur J Pediatr. 1997;156:190–4.

    Article  CAS  PubMed  Google Scholar 

  20. Dottorini ME, et al. Differentiated thyroid carcinoma in children and adolescents: a 37-year experience in 85 patients. J Nucl Med. 1997;38(5):669–75.

    PubMed  CAS  Google Scholar 

  21. Farahati J, et al. Differentiated thyroid cancer in children and adolescents. Langerbeck’s Arch Surg. 1998;383(3–4):235–9.

    Article  CAS  Google Scholar 

  22. Frankenthaler RA, et al. Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients. Am J Surg. 1990;160(4):341–3.

    Article  CAS  PubMed  Google Scholar 

  23. Hallwirth U, et al. Differentiated thyroid cancer in children and adolescents: the importance of adequate surgery and review of literature. Eur J Pediatr Surg. 1999;9(6):359–63.

    Article  CAS  PubMed  Google Scholar 

  24. Harness JK, et al. Differentiated thyroid carcinoma in children and adolescents. World J Surg. 1992;16(4):547–53.

    Article  CAS  PubMed  Google Scholar 

  25. Haveman JW, et al. Surgical experience in children with differentiated thyroid carcinoma. Ann Surg Oncol. 2003;10(1):15–20.

    Article  PubMed  Google Scholar 

  26. La Quaglia MP, et al. Recurrence and morbidity in differentiated thyroid carcinoma in children. Surgery. 1988;104:1149–56.

    PubMed  Google Scholar 

  27. Machens A, et al. Papillary thyroid cancer in children and adolescents does not differ in growth pattern and metastatic behavior. J Pediatr. 2010;157(4):648–52.

    Article  PubMed  Google Scholar 

  28. Massimino M, et al. Primary thyroid carcinoma in children: a retrospective study of 20 patients. Med Pediatr Oncol. 1995;24(1):13–7.

    Article  CAS  PubMed  Google Scholar 

  29. Massimino M, et al. Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma in children and adolescents. Pediatr Blood Cancer. 2006;46:307–13.

    Article  PubMed  Google Scholar 

  30. Miccoli P, et al. Papillary thyroid cancer: pathological parameters as prognostic factors in different classes of age. Otolaryngol Head Neck Surg. 2008;138(2):200–3.

    Article  PubMed  Google Scholar 

  31. Newman KD, et al. Differentiated thyroid cancer: determinants of disease progression in patients <21 years of age at diagnosis: a report from the surgical discipline committee of the children’s cancer group. Ann Surg. 1998;227(4):533–41.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  32. Robie DK, et al. The impact of initial surgical management on outcome in young patients with differentiated thyroid cancer. J Pediatr Surg. 1998;33(7):1134–8.

    Article  CAS  PubMed  Google Scholar 

  33. Schlumberger M, et al. Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients. J Clin Endocrinol Metab. 1987;65(6):1088–94.

    Article  CAS  PubMed  Google Scholar 

  34. Wada N, et al. Pediatric differentiated thyroid carcinoma in stage 1: risk factor analysis for disease free survival. BMC Cancer. 2009;9:306.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Wada N, et al. Treatment strategy of papillary thyroid carcinoma in children and adolescents: clinical significance of the initial nodal manifestation. Ann Surg Oncol. 2009;16(12):3442–9.

    Article  PubMed  Google Scholar 

  36. Welch Dinauer CA, et al. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clin Endocrinol. 1998;49(5):619–28.

    Article  CAS  Google Scholar 

  37. Welch Dinauer CA, et al. Extensive surgery improves recurrence-free survival for children and young patients with class 1 papillary thyroid carcinoma. J Pediatr Surg. 1999;34(12):1799–804.

    Article  CAS  PubMed  Google Scholar 

  38. Zimmerman D, et al. Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades. Surgery. 1988;104(6):1157–66.

    PubMed  CAS  Google Scholar 

  39. Bargren AE, et al. Outcomes of surgically managed pediatric thyroid cancer. J Surg Res. 2009;156(1):70–3.

    Article  PubMed  Google Scholar 

  40. Bingol-Kologlu M, et al. Surgical treatment of differentiated thyroid carcinoma in children. Eur J Pediatr Surg. 2000;10:347–52.

    Article  CAS  PubMed  Google Scholar 

  41. Demidchik YE, et al. Comprehensive clinical assessment of 740 cases of surgically treated thyroid cancer in children of Belarus. Ann Surg. 2006;243(4):525–32.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Karnak I, et al. Papillary thyroid carcinoma does not have standard course in children. Pediatr Surg Int. 2011;27:931–6.

    Article  PubMed  Google Scholar 

  43. Kuefer MU, et al. Papillary thyroid carcinoma: demographics, treatment, and outcome in eleven pediatric patients treated at a single institution. Med Pediatr Oncol. 1997;28(6):433–40.

    Article  CAS  PubMed  Google Scholar 

  44. Popovtzer A, et al. Thyroid cancer in children: management and outcome experience of a referral center. Otolaryngol Head Neck Surg. 2006;135(4):581–4.

    Article  PubMed  Google Scholar 

  45. Spinelli C, et al. Surgical therapy of the thyroid papillary carcinoma in children: experience with 56 patients ≤16 years old. J Pediatr Surg. 2004;39(10):1500–5.

    Article  PubMed  Google Scholar 

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Correspondence to Benjamin James .

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James, B., Grogan, R.H., Kaplan, E.L., Angelos, P. (2018). Prophylactic Versus Selective Central Neck Dissection in Pediatric Papillary Thyroid Cancer. In: Angelos, P., Grogan, R. (eds) Difficult Decisions in Endocrine Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-319-92860-9_14

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  • DOI: https://doi.org/10.1007/978-3-319-92860-9_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92858-6

  • Online ISBN: 978-3-319-92860-9

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