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Arrhythmia Induction in the EP Lab pp 141–149Cite as

How to Induce Arrhythmias with Aminophylline?

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Abstract

Aminophylline, a methylxanthine, is a 2:1 combination between theophylline and ethylenediamine. The 2:1 ratio improves the solubility of the product. Compared to theophylline, aminophylline is a less potent nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. The effects on the sinus node are reduction in the corrected sinus node recovery time and sinoatrial conduction time. The effect on the atrial tissue is reduction in the atrial refractory period. The effect on the AV node was decrease in the Wenckebach point and AH time. The effect on the His-Purkinje system is reduction in the HV conduction time. There was no change in the ventricular refractory period.

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Author information

Authors and Affiliations

  1. Royal Brompton and Harefield, NHS Trust, London, UK

    Habib Rehman Khan

  2. National Heart and Lung Institute, Imperial College, London, UK

    Habib Rehman Khan

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  1. Habib Rehman Khan
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Editors and Affiliations

  1. Electrophysiology Laboratory, Rehabilitation Hospital, Iuliu Hatieganu University of Medicine and Pharmacy 5th Department of Internal Medicine, Cardiology-Rehabilitation, Cluj-Napoca, Romania

    Gabriel Cismaru

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Khan, H.R. (2019). How to Induce Arrhythmias with Aminophylline?. In: Cismaru, G. (eds) Arrhythmia Induction in the EP Lab. Springer, Cham. https://doi.org/10.1007/978-3-319-92729-9_15

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  • DOI: https://doi.org/10.1007/978-3-319-92729-9_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92728-2

  • Online ISBN: 978-3-319-92729-9

  • eBook Packages: MedicineMedicine (R0)

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