Skip to main content
SpringerLink
Log in

Neurobrucellosis

  • Chapter
  • First Online:
Meningitis and Encephalitis

Abstract

Brucellosis, also known as “undulant fever,” “Mediterranean fever,” or “Malta fever,” is an important human zoonosis and a major public health issue in many parts of the world especially in the Mediterranean countries of Europe, North and East Africa, the Middle East, South and Central Asia, and Central and South America [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Corbel MJ, et al. Brucellosis in humans and animals. WHO/CDS/EPR/2006.7.

    Google Scholar 

  2. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006;6(2):91–9.

    Article  PubMed  Google Scholar 

  3. Al-Sekait MA. Epidemiology of brucellosis in Al Medina region, Saudi Arabia. J Fam Community Med. 2000;7(1):47–53.

    CAS  Google Scholar 

  4. Aloufi A, Memish Z, Assiri M, McNabb S. Trends of reported human cases of brucellosis, Kingdom of Saudi Arabia, 2004–2012. J Epidemiol Glob Health. 2016;6:11–8.

    Article  PubMed  Google Scholar 

  5. Alhedaithy A, Aldubayan N, Alqurashi D, Aldubayan S. Clinical-features, serological patterns and long-term complications of 22 patients with neurobrucellosis. Int J Adv Res. 2016;4(10):1682–9.

    Article  Google Scholar 

  6. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Evirgen O, Akdeniz H. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14:e469–78.

    Article  PubMed  Google Scholar 

  7. Guven T, Ugurlu K, Ergonul O, Celikbas AK, Gok SE, Comoglu S, et al. Neurobrucellosis: clinical and diagnostic features. Clin Infect Dis. 2013;56(10):1407–12.

    Article  CAS  PubMed  Google Scholar 

  8. Panayiotopoulos CP. Neurobrucellosis: a cause for concern and action. Ann Saudi Med. 1988;8(30):167–8.

    Article  Google Scholar 

  9. Paul E, Abdelkareem M, Malik S. Overview of human brucellosis in Aseer region, Saudi Arabia. AMJ. 2017;10(3):202–10.

    Article  Google Scholar 

  10. Pourhassan A. Clinical and laboratory findings in neurobrucellosis: a study of 43 cases. Iran J Clin Infect Dis. 2007;2(2):71–6.

    Google Scholar 

  11. Erdem H, Senbayrak S, Gencer S, Hasbun R, Karahocagil M, Sengoz G. Tuberculous and brucellosis meningitis differential diagnosis. Travel Med Infect Dis. 2015;13(2):185–91.

    Article  PubMed  Google Scholar 

  12. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352:2325.

    Article  CAS  PubMed  Google Scholar 

  13. Karsen H, Koruk S, Karahocagil M, Calisir C, Baran F. Comparative analysis of cerebrospinal fluid adenosine deaminase activity in meningitis. Swiss Med Wkly. 2011;141:w13214.

    PubMed  Google Scholar 

  14. Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis. 1995;15:115.

    Article  CAS  PubMed  Google Scholar 

  15. Aliskan H. The value of culture and serological methods in the diagnosis of human brucellosis. Mikrobiyol Bul. 2008;42:185–95.

    PubMed  CAS  Google Scholar 

  16. Shenoy B, Jaiswal A, Vinod A. Lab diagnosis of brucellosis. Pediatr Infect Dis. 2016;8:40–4.

    Article  Google Scholar 

  17. Serra J, Viñas M. Laboratory diagnosis of brucellosis in a rural endemic area in northeastern Spain. Int Microbiol. 2004;7:53.

    PubMed  Google Scholar 

  18. Araj GF. Update on laboratory diagnosis of human brucellosis. Int J Antimicrob Agents. 2010;36:12–7.

    Article  CAS  Google Scholar 

  19. Geresu MA, Kassa GM. A review on diagnostic methods of brucellosis. J Vet Sci Technol. 2016;7:323.

    Google Scholar 

  20. Lucero NE, Escobar GI, Ayala SM, Jacob N. Diagnosis of human brucellosis caused by Brucella canis. J Med Microbiol. 2005;54:457–61.

    Article  PubMed  Google Scholar 

  21. Christopher S, Umapathy BL, Ravikumar KL. Brucellosis: review on the recent trends in pathogenicity and laboratory diagnosis. J Lab Physicians. 2010;2:55–60.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Sun Y-H, Rolan HG, den Hartigh AB, Sondervan D, Tsolis RM. Brucella abortus VirB12 is expressed during infection but is not an essential component of the type IV secretion system. Infect Immun. 2005;73:6048–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Özdemir M, Feyzioglu B, Kurtoglu MG, et al. A comparison of immunocapture agglutination and ELISA methods in serological diagnosis of brucellosis. Int J Med Sci. 2011;8(5):428–32.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Andriopoulos P, Tsironi M. Molecular diagnosis of brucellosis: a brief report. Adv Mol Diag. 2016;1:108.

    Article  Google Scholar 

  25. Sanjuuan-Jimenez R, Colmenero J, Bermudez P, Alonso A, Morata P. Amplicon DNA melting analysis for the simultaneous detection of Brucella spp and Mycobacterium tuberculosis complex. Potential use in rapid differential diagnosis between extrapulmonary tuberculosis and focal complication of brucellosis. PLoS One. 2013;8(3):e58353.

    Article  CAS  Google Scholar 

  26. Kizilkilic O. Neurobrucellosis. Neuroimaging Clin N Am. 2011;21:927–37.

    Article  PubMed  Google Scholar 

  27. Erdem H, Senbayrak S, Meriç K, Batirel A, Karahocagil MK, Hasbun R, et al. Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study. Infection. 2016;44(5):623–3127.

    Article  PubMed  Google Scholar 

  28. Ulu-Kilic A, Sayar MS, Tutuncu E, Sezen F, Sencan I. Complicated brucellar spondylodiscitis: experience from an endemic area. Rheumatol Int. 2013;33(11):2909–12.

    Article  CAS  PubMed  Google Scholar 

  29. Alp E, Doganay M. Current therapeutic strategy in spinal brucellosis. Int J Infect Dis. 2008;12:573–7.

    Article  CAS  PubMed  Google Scholar 

  30. Daif AK. The value of oligoclonal bands in neurobrucellosis. Ann Saudi Med. 1991;11(4):411–3.

    Article  CAS  PubMed  Google Scholar 

  31. Erdem H, Ulu-Kilic A, Kilic S, et al. Efficacy and tolerability of antibiotic combinations in neurobrucellosis: results of the Istanbul study. Antimicrob Agents Chemother. 2012;56(3):1523–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Pappas G, Akritidis N, Christou L. Treatment of neurobrucellosis: what is known and what remains to be answered. Expert Rev Anti Infect Ther. 2007;5(6):983–90.

    Article  CAS  PubMed  Google Scholar 

  33. Madjdinasab N, Naieni AR. Neurobrucellosis and steroid therapy. Iran J Clin Infect Dis. 2006;1(2):103–7.

    Google Scholar 

  34. Alshaalan MA, Alalola SA, Almuneef M, Albanyan EA, Balkhy HH, AlShahrani DA, AlJohani S. Brucellosis in children: prevention, diagnosis and management guidelines for general pediatricians endorsed by the Saudi Pediatric Infectious Diseases Society (SPIDS). Int J Pediatr Adolesc Med. 2014;1:40e46.

    Article  Google Scholar 

  35. Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med. 2007;4(12):e317.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Musallam I, Abo-Shehada M, Hegazy Y, Holt H, Guitian F. Systematic review of brucellosis in the Middle East: disease frequency in ruminants and humans and risk factors for human infection. Epidemiol Infect. 2016;144(4):671–85.

    Article  CAS  PubMed  Google Scholar 

  37. Norman FF, Monge-Maillo B, Chamorro-Tojeiro S, Pérez-Molina JA, Lopez-Velez R. Imported brucellosis: a case series and literature review. Travel Med Infect Dis. 2016;14(3):182–99.

    Article  PubMed  Google Scholar 

  38. Yoldas T, Tezer H, Ozkaya-Parlakay A, Sayli TR. Clinical and laboratory findings of 97 pediatric brucellosis patients in Central Turkey. J Microbiol Immunol Infect. 2015;48:446–9.

    Article  PubMed  Google Scholar 

  39. Franco MP, Mulder M, Gilman RH, Smits HL. Human brucellosis. Lancet Infect Dis. 2007;7:775–6.

    Article  CAS  PubMed  Google Scholar 

  40. Plumb GE, Olsen SC, Buttke D. Brucellosis: ‘one health’ challenges and opportunities. Rev Sci Tech. 2013;32(1):271–8.

    Article  CAS  PubMed  Google Scholar 

  41. Solera J. Update on brucellosis: therapeutic challenges. Int J Antimicrob Agents. 2010;36(Suppl 1):S18–20.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Section of Infectious Diseases, King Fahad Medical City, Riyadh, Saudi Arabia

    Mushira Abdulaziz Enani

Authors
  1. Mushira Abdulaziz Enani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mushira Abdulaziz Enani .

Editor information

Editors and Affiliations

  1. UT Health-McGovern Medical School, Houston, Texas, USA

    Rodrigo Hasbun

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Enani, M.A. (2018). Neurobrucellosis. In: Hasbun, R. (eds) Meningitis and Encephalitis. Springer, Cham. https://doi.org/10.1007/978-3-319-92678-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-92678-0_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92677-3

  • Online ISBN: 978-3-319-92678-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation