Abstract
A survey of studies carried out at the Chuiko Institute of Surface Chemistry NAS of Ukraine aimed at developing the concept of creating magnetosensitive nanocomposites (NK) with multilevel hierarchical nanoscale architecture and functions of biomedical nanorobots. The data on the synthesis of magnetically sensitive nanocomposites of core-shell type on the basis of single-domain magnetite and hydroxyapatite, the study of their magnetic properties, features of immobilization on the surface of oncological preparations of different action mechanisms, bioactivity testing, creation of magnetic fluids on the basis of synthesized NK, and the establishment of the prospects of their use in oncology are presented.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abramov N (2014) Magnetic fluid on the basis of doxorubicin for the application in oncology. Surface 6(21):241–258
Abramov N, Turanska S, Kusyak A, Petranovska A, Gorbyk P (2016) Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them. J Nanostruct Chem 6:223–233
Anirudhan T, Sandeep S (2012) Synthesis, characterization, cellular uptake and cytotoxicity of a multi-functional magnetic nanocomposite for the targeted delivery and controlled release of doxorubicin to cancer cells. J Mater Chem 22:12888–12899
Bellin M-F (2006) MR contrast agents, the old and the new. Eur J Radiol 60:314–323
Caravan P (2006) Strategies for increasing the sensitivity of gadolinium based MRI contrast agents. Chem Soc Rev 35:512–523
Chen F, Li C, Zhu Y-J, Zhao X-Y, Lu B-Q, Wu J (2013) Magnetic nanocomposite of hydroxyapatite ultrathin nanosheets/Fe 3 O 4 nanoparticles: microwave-assisted rapid synthesis and application in pH-responsive drug release. Biomater Sci 1:1074–1081
Davaran S, Alimirzalu S, Nejati-Koshki K, Nasrabadi HT, Akbarzadeh A, Khandaghi AA, Abbasian M, Alimohammadi S (2014) Physicochemical characteristics of Fe. Asian Pac J Cancer Prev 15:49–54
Fukumori Y, Ichikawa H (2006) Nanoparticles for cancer therapy and diagnosis. Adv Powder Technol 17:1–28
Gopi D, Ansari MT, Shinyjoy E, Kavitha L (2012) Synthesis and spectroscopic characterization of magnetic hydroxyapatite nanocomposite using ultrasonic irradiation. Spectrochim Acta A Mol Biomol Spectrosc 87:245–250
Gorbyk P (2013) Nanocomposites with medico-biological properties: synthesis, properties and application. Nanosyst Nanomater Nanotechnol 11:323–436
Gorbyk P, Chekhun V, Vovk R, Nazyrov Z, Kruglyak V, Ogrin F, Edelman I, Malakhovskii A, Sokolov A, Sukhachev A (2012) Nanocomposites of medicobiologic destination: reality and perspectives for oncology. Funct Mater 19:145
Gorbyk P, Lerman L, Petranovska A & Turanska S (2014) Magnetosensitive nanocomposites with functions of medico-biological nanorobots: synthesis and properties. In book: Advances in Semiconductor Research: Physics of Nanosystems, Spintronics and Technological Applications. 161–198
Gorbyk, P., Petranovska, A., Usov, D. & Storozhuk, L. 2012. Nanocapsule with nanorobots function. Patent of Ukraine
Gorbyk P, Petranovskaya A, Pilipchuk E, Abramov N, Oranskaya E, Korduban A (2012) Synthesis of magnetosensitive Gd-containing nanostructures. Chem Phys Technol Surface/Khimiya, Fizyka ta Tekhnologiya Poverhni 2
Gorbyk P, Turov V (2011) Nanomaterials and nanocomposites in medicine, biology, ecology. Naukova Dumka, Kyiv
Grumezescu A (2016) Fabrication and self-assembly of Nanobiomaterials. Appl Nanobiomater, William Andrew
Huang C, Zhou Y, Tang Z, Guo X, Qian Z, Zhou S (2011) Synthesis of multifunctional Fe3O4 core/hydroxyapatite shell nanocomposites by biomineralization. Dalton Trans 40:5026–5031
Iwasaki T (2013) Mechanochemical synthesis of magnetite/hydroxyapatite nanocomposites for hyperthermia. In: Moshe H, Mastai Y (eds.) Materials science-advanced topics. InTech Open, UK
Kule C, Ondrejickova O, Verner K (1994) Doxorubicin, daunorubicin, and mitoxantrone cytotoxicity in yeast. Mol Pharmacol 46:1234–1240
Levy L, Sahoo Y, Kim K-S, Bergey EJ, Prasad PN (2002) Nanochemistry: synthesis and characterization of multifunctional nanoclinics for biological applications. Chem Mater 14:3715–3721
Lowe MP (2002) MRI contrast agents: the next generation. Aust J Chem 55:551–556
Mir A, Mallik D, Bhattacharyya S, Mahata D, Sinha A, Nayar S (2010) Aqueous ferrofluids as templates for magnetic hydroxyapatite nanocomposites. J Mater Sci Mater Med 21:2365–2369
Patel S, Sprung AU, Keller BA, Heaton VJ, Fisher LM (1997) Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity. Mol Pharmacol 52:658–666
Petranovska A, Abramov N, Turanska S, Gorbyk P, Kaminskiy A, Kusyak N (2015) Adsorption of cis-dichlorodiammineplatinum by nanostructures based on single-domain magnetite. J Nanostruct Chem 5:275–285
Petranovskaya A, Turelik M, Pilipchuk E, gorbik P, Korduban A, Ivashishin O (2013) Formation of biomimetic hydroxyapatite on the surface of titanium. Metallophys Latest Technol 35:1567–1584
Pharmacopoeia TE (2008) The European Pharmacopoeia sixth edition, 2008. In: ISBN
Pylypchuk E, Gorbyk P (2014) B- and Gd-containing nanomaterials and nanocomposites for neutron capture therapy. Surface:150–183
Pylypchuk E, Petranovska A, Gorbyk P (2012) Synthesis and properties of nanocomposites based on magnetite modified with DTPA. Nanostrukturnoye Materialovedeniye (Nanostruct Mater Sci) 3:47
Pylypchuk IV, Kołodyńska D, Gorbyk P (2017) Gd (III) adsorption on the DTPA-functionalized chitosan/magnetite nanocomposites. Separat Sci Technol 53(7):1006–1016
Pylypchuk IV, Kołodyńska D, Kozioł M, Gorbyk P (2016) Gd-DTPA adsorption on chitosan/magnetite nanocomposites. Nanoscale Res Lett 11:168
Pylypchuk IV, Petranovska AL, Turelyk MP, Gorbyk PP (2014) Formation of biomimetic hydroxyapatite coating on titanium plates. Mater Sci 20:328–332
Pylypchuk IV, Petranovskaya A, Gorbyk P, Korduban A, Markovsky P, Ivasishin O (2015) Biomimetic hydroxyapatite growth on functionalized surfaces of Ti-6Al-4V and Ti-Zr-Nb alloys. Nanoscale Res Lett 10:338
Pylypchuk IV, Zubchuk YO, Petranovskaya A, Turanska S, Gorbyk P (2015) Synthesis and properties of Fe3O4/HA/pamidronic acid/DTPA-Gd nanocomposites. Хімія, фізика та технологія поверхні 6:326–335
Sadighian S, Hosseini-Monfared H, Rostamizadeh K, Hamidi M (2015) pH-Triggered magnetic-chitosan nanogels (MCNs) for doxorubicin delivery: physically vs. chemically cross linking approach. Advan Pharmaceut Bull 5:115
Saenko YV, Shutov A, Rastorgueva E (2010) Doxorubicin and menadione decrease cell proliferation of Saccharomyces cerevisiae by different mechanisms. Cell Tissue Biol 4:332–336
Shpak A, Gorbyk P (2007) Physical chemistry of Nanomaterials and Supramolecular structures. Naukova Dumka, Kyiv
Shpak AP, Gorbyk PP (2010) Nanomaterials and supramolecular structures. Physics chemistry and applications. Springer, Netherlands
Shylova OA, Shylov V (2003) Nanocomposite oxide and hybrid organo-inorganic materials produced by the sol-gel method. Nanosyst Nanomater Nanotechnol 1:9–83
Turanska S, Kusyak A, Petranovska A, Turov V, Gorbyk P (2016) Cytotoxic activity of magnet-quided doxorubicin-based nanocomposites with Saccharomyces cerevisiae cells as an example. Chem Phys Technol Surface 7:236–245
Turelik M, Gorobets S, Makedonska A, Gorbik P (2012) Biofunctionalization of nanocomposites on the basis of magnet-ite, modified by meso-2, 3-dimercaptosuccinic acid. Research Bulletin of NTUU” Kyiv Polytechnic Institute. 149–154
Wahajuddin SA (2012) Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomedicine 7:3445
Acknowledgments
The work was carried out with the support of the target comprehensive program of fundamental research of the National Academy of Sciences of Ukraine “Fundamental problems of the creation of new nanomaterials and nanotechnologies” for 2015–2019 (Project No. 38/17-n). The publication contains the results of research conducted with the grant support of the State Fund for Fundamental Research (project 31566).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this paper
Cite this paper
Pylypchuk, I.V. et al. (2018). Multifunctional Magnetic Nanocomposites on the Base of Magnetite and Hydroxyapatite for Oncology Applications. In: Fesenko, O., Yatsenko, L. (eds) Nanochemistry, Biotechnology, Nanomaterials, and Their Applications. NANO 2017. Springer Proceedings in Physics, vol 214. Springer, Cham. https://doi.org/10.1007/978-3-319-92567-7_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-92567-7_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-92566-0
Online ISBN: 978-3-319-92567-7
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)