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Trauma, Inflammation, Cochlear Implantation Induced Hearing Loss and Otoprotective Strategies to Limit Hair Cell Death and Hearing Loss

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Inflammatory Mechanisms in Mediating Hearing Loss

Abstract

Hair cells are highly sensitive units that in response to trauma, inflammation, and cochlear implantation activate different signaling pathways leading to hair cell death and hearing impairment. In this chapter we discuss the most recent literature regarding signaling pathways of hair cell loss, mechanisms and inflammatory responses after noise exposure and electrode insertion, and otoprotective strategies that can limit hair cell death and hearing loss.

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Correspondence to Thomas R. Van De Water .

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Goncalves, S., Perez, E., Bas, E., Dinh, C.T., Van De Water, T.R. (2018). Trauma, Inflammation, Cochlear Implantation Induced Hearing Loss and Otoprotective Strategies to Limit Hair Cell Death and Hearing Loss. In: Ramkumar, V., Rybak, L. (eds) Inflammatory Mechanisms in Mediating Hearing Loss. Springer, Cham. https://doi.org/10.1007/978-3-319-92507-3_9

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