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Cnidarian Jellyfish: Ecological Aspects, Nematocyst Isolation, and Treatment Methods of Sting

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Marine Organisms as Model Systems in Biology and Medicine

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 65))

Abstract

Cnidarians play an important role in ecosystem functioning, in the competition among species, and for possible utilization of several active compounds against cardiovascular, nervous, endocrine, immune, infective, and inflammatory disorders or having antitumoral properties, which have been extracted from these organisms. Nevertheless, notwithstanding these promising features, the main reason for which cnidarians are known is due to their venomousness as they have a serious impact on public health as well as in economy being able to affect some human activities. For this reason a preeminent subject of the research about cnidarians is the organization of proper systems and methods of care and treatment of stinging. This chapter aims to present the data about the morphological, ecological, toxicological, epidemiological, and therapeutic aspects regarding cnidarians with the purpose to summarize the existing knowledge and to stimulate future perspectives in the research on these organisms.

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References

  • Allavena A, Mariottini GL, Carli AM et al (1998) In vitro evaluation of the cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s). Toxicon 36:933–936

    Article  PubMed  CAS  Google Scholar 

  • Al-Rubiay KK, Al-Musaoi HA, Alrubaiy L et al (2009) Skin and systemic manifestations of jellyfish stings in Iraqi fishermen. Libyan J Med 4(2):75–77

    Article  PubMed  PubMed Central  Google Scholar 

  • Anderluh G, Maček P (2002) Cytolytic peptide and protein toxins from sea anemones (Anthozoa: Actiniaria). Toxicon 40:111–124

    Article  PubMed  CAS  Google Scholar 

  • Arai MN (1988) Interactions of fish and pelagic coelenterates. Can J Zool 66:1913–1927

    Article  Google Scholar 

  • Arai MN (1997) A functional biology of Scyphozoa. Chapman & Hall, London

    Google Scholar 

  • Arai MN (2001) Pelagic coelenterates and eutrophication: a review. Hydrobiologia 451:69–87

    Article  Google Scholar 

  • Arai MN (2005) Predation on pelagic coelenterates: a review. J Mar Biol Assoc UK 85:523–536

    Article  Google Scholar 

  • Astorga D, Ruiz J, Prieto L (2012) Ecological aspects of early life stages of Cotylorhiza tuberculata (Scyphozoa: Rhizostomae) affecting its pelagic population success. Hydrobiologia 690(1):141–155

    Article  Google Scholar 

  • Asztalos ML, Rubin AI, Elenitsas R et al (2014) Recurrent dermatitis and dermal hypersensitivity following a jellyfish sting: a case report and review of literature. Pediatr Dermatol 31(2):217–219

    Article  Google Scholar 

  • Auerbach PS (2013) In reply to evidence-based treatment of jellyfish stings in North America and Hawaii. Ann Emerg Med 61(2):253–254

    Article  PubMed  Google Scholar 

  • Avila AD, Mateo de Acosta C, Lage A (1988) A new immunotoxin built by linking a haemolytic toxin to a monoclonal antibody specific for immature T lymphocytes. Int J Cancer 42:568–571

    Article  PubMed  CAS  Google Scholar 

  • Ayed Y, Bousabbeh M, Mabrouk HB et al (2012) Impairment of the cell-to-matrix adhesion and cytotoxicity induced by the Mediterranean jellyfish Pelagia noctiluca venom and its fractions in cultured glioblastoma cells. Lipids Health Dis 11:84

    Article  PubMed  PubMed Central  Google Scholar 

  • Ayyad S-EN, Alarif WM, Al-Footy KO et al (2017) Isolation, antimicrobial and antitumor activities of a new polyhydrsteroid and a new diterpenoid from the soft coral Xenia umbellata. Z Naturforsch C 72(1–2):27–34

    Article  PubMed  CAS  Google Scholar 

  • Azuma H, Ishikawa M, Nakajima T et al (1986a) Calcium-dependent contractile response of arterial smooth muscle to a jellyfish toxin (pCrTX: Carybdea rastonii). Br J Pharmacol 88:549–559

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Azuma H, Sekizaki S, Satoh A et al (1986b) Platelet aggregation caused by a partially purified jellyfish toxin from Carybdea rastonii. Toxicon 24:489–499

    Article  PubMed  CAS  Google Scholar 

  • Azuma H, Sekizaki S, Satoh A et al (1986c) Platelet aggregation caused by Carybdea rastonii toxins (CrTX-I, II and III) obtained from a jellyfish, Carybdea rastonii (42305). Proc Soc Exp Biol Med 182:34–42

    Article  PubMed  CAS  Google Scholar 

  • Balhara KS, Stolbach A (2014) Marine envenomations. Emerg Med Clin North Am 32:223–243

    Article  PubMed  Google Scholar 

  • Båmstedt U, Kaartvedt S, Youngbluth M (2003) An evaluation of acoustic and video methods to estimate the abundance and vertical distribution of jellyfish. J Plankton Res 25(11):1307–1318

    Article  Google Scholar 

  • Barham EG (1963) Siphonophores and the deep scattering layer. Science 140(3568):826–828

    Article  PubMed  CAS  Google Scholar 

  • Baxter EJ, Sturt MM, Ruane NM et al (2011) Gill damage to Atlantic salmon (Salmo salar) caused by the common jellyfish (Aurelia aurita) under experimental challenge. PLoS One 6(4):e18529

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Becerra-Amezcua MP, Guerrero-Legarreta I, Gonzáalez-Márquez H et al (2016) In vivo analysis of effects of venom from the jellyfish Chrysaora sp. in zebrafish (Danio rerio). Toxicon 113:49–54

    Article  PubMed  CAS  Google Scholar 

  • Beckmann A, Özbek S (2012) The Nematocyst: a molecular map of the Cnidarian stinging organelle. Int J Dev Biol 56:577–582

    Article  PubMed  CAS  Google Scholar 

  • Berling I, Isbister G (2015) Marine envenomations. Aust Fam Physician 44(1–2):28–32

    PubMed  Google Scholar 

  • Berryman M (2005) Upside-down jellyfish: Cassiopea xamachana. Available via www. thecephalopodpage.org. Accessed 3 Mar 2012

  • Boero F (2013) Review of jellyfish blooms in the Mediterranean and Black Sea. Studies and Reviews, General Fisheries Commission for the Mediterranean 92. FAO, Rome

    Google Scholar 

  • Boero F, Bouillon J, Gravili C et al (2008) Gelatinous plankton: irregularities rule the world (sometimes). Mar Ecol Prog Ser 356:299–310

    Article  Google Scholar 

  • Boero F, Brotz L, Gibbons MJ et al (2016) Impacts and effects of ocean warming on jellyfish. IUCN, Gland, pp 213–237

    Google Scholar 

  • Bos AR, Cruz-Rivera E, Sanad AM (2017) Herbivorous fishes Siganus rivulatus (Siganidae) and Zebrasoma desjardinii (Acanthuridae) feed on Ctenophora and Scyphozoa in the Red Sea. Mar Biodivers 47(1):243–246

    Article  Google Scholar 

  • Bosch-Belmar M, M’Rabet C, Dhaouadi R et al (2016) Jellyfish stings trigger gill disorders and increased mortality in farmed Sparus aurata (Linnaeus, 1758) in the Mediterranean Sea. PLoS One 11:e0154239

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bouillon J (1987) Considerations sur le development des Narcomeduses et sur leur position phylogenetique. Indo-Malayan Zool 4:189–278

    Google Scholar 

  • Brinkman D, Burnell J (2007) Identification, cloning and sequencing of two major venom proteins from the box jellyfish, Chironex fleckeri. Toxicon 50:850–860

    Article  PubMed  CAS  Google Scholar 

  • Brinkman D, Burnell J (2008) Partial purification of cytolytic venom proteins from the box jellyfish, Chironex fleckeri. Toxicon 51:853–863

    Article  PubMed  CAS  Google Scholar 

  • Brinkman DL, Burnell JN (2009) Biochemical and molecular characterisation of cubozoan protein toxins. Toxicon 54:1162–1173

    Article  PubMed  CAS  Google Scholar 

  • Brodeur RD (1998) In situ observations of the association between juvenile fishes and scyphomedusae in the Bering Sea. Mar Ecol Prog Ser 163:11–20

    Article  Google Scholar 

  • Brown CW, Hood RR, Li Z et al (2002) Forecasting system predicts presence of sea nettles in Chesapeake Bay. EOS. Trans Am Geophys Union 83(321):325–326

    Google Scholar 

  • Brown SA, Seifert SA, Rayburn WF (2013) Management of envenomations during pregnancy. Clin Toxicol 51:3–15

    Article  CAS  Google Scholar 

  • Browne JG, Pitt KA, Norman MD (2017) Temporal patterns of association between the jellyfish Catostylus mosaicus and a sphaeromatid isopod and parasitic anemone. Mar Freshw Res 68(9):1771–1777

    Article  Google Scholar 

  • Brueggeman P (1998) Cnidaria–Scyphozoa: jellyfish. Scripps Institution of Oceanography Library, San Diego

    Google Scholar 

  • Buecher E, Goy J, Planque B, Etienne M, Dallot S (1997) Long-term fluctuations of Liriope tetraphylla in Villefranche Bay between 1966 and 1993 compared to Pelagia noctiluca pullulations. Oceanol Acta 20:145–157

    Google Scholar 

  • Bulati M, Longo A, Masullo T et al (2016) Partially purified extracts of sea anemone Anemonia viridis affect the growth and viability of selected tumour cell lines. Biomed Res Int 2016:Article ID 3849897

    Article  CAS  Google Scholar 

  • Burnett JW, Cobbs CS, Kelman SN et al (1983) Studies on the serologic response to jellyfish envenomation. J Am Acad Dermatol 9:229–231

    Article  PubMed  CAS  Google Scholar 

  • Caddy JF, Griffiths RC (1990) Recent trends in the fisheries and environment in the General Fisheries Council for the Mediterranean (GFCM) area (No. 63). Food and Agriculture Organization

    Google Scholar 

  • Calder DR (1972) Development of the sea nettle Chrysaora quinquecirrha (scyphozoa, semaeostomeae). Chesap Sci 13(1):40–44

    Article  Google Scholar 

  • Cannon Q, Wagner E (2003) Comparison of discharge mechanisms of cnidarian cnidae and myxozoan polar capsules. Rev Fish Sci 11:185–219

    Article  Google Scholar 

  • Cariello L, Romano G, Spagnuolo A et al (1988) Isolation and partial characterization of rhizolysin, a high molecular weight protein with hemolytic activity from the jellyfish Rhizostoma pulmo. Toxicon 26:1057–1065

    Article  PubMed  CAS  Google Scholar 

  • Cates N, McLaughlin JJA (1976) Differences of ammonia metabolism in symbiotic and aposymbiotic Condylactus and Cassiopea spp. J Exp Mar Biol Ecol 21:1–5

    Article  CAS  Google Scholar 

  • Cegolon L, Heymann WC, Lange JH et al (2013) Jellyfish stings and their management: A review. Mar Drugs 11:523–550

    Article  PubMed  PubMed Central  Google Scholar 

  • Chao C-H, Li W-L, Huang C-Y et al (2017) Isoprenoids from the Soft Coral Sarcophyton glaucum. Mar Drugs 15:202

    Article  PubMed Central  Google Scholar 

  • Chen W, Bo Z, Zhou W, Xue L (2007) Investigation of the familiar jellyfish species in Zhejiang Sea area and their influence on fishery in flourishing year. J Zhejiang Ocean Univ (Nat Sci) 26:266–271 (in Chinese)

    Google Scholar 

  • Cheng J, Li S, Ding F, Yan L (2004) Primary analysis on the jellyfish bloom and its cause in the East China Sea and the Yellow Sea. Modern Fish Inf 19:10–12 (in Chinese)

    Google Scholar 

  • Choong CYL, Chan HZ, Faruk NA et al (2015) Jellyfish envenomation resulting in vascular insufficiency and neurogenic injury of upper limb. Malays Orthop J 9(3):49–51

    Article  PubMed  PubMed Central  Google Scholar 

  • Choudhary I, Lee H, Pyo M-J et al (2015) Proteomics approach to examine the cardiotoxic effects of Nemopilema nomurai Jellyfish venom. J Proteome 128:123–131

    Article  CAS  Google Scholar 

  • Chung JJ, Fernandez K, Ratnapala LA et al (2000) Partial purification and characterization of Hawaiian box jellyfish (Carybdea alata) venom. Pac Sci 54:90

    Google Scholar 

  • CIESM (Commission Internationale pour l’Exploration Scientifique de la mer Méditerranée) (2001) Gelatinous zooplankton outbreaks: theory and practice. CIESM Work- shop Series No. 14, Monaco. Available at www.ciesm.org/publications/Naples01.pdf

  • Cline EI, Wiebe LI, Young JD et al (1995) Toxic effects of the novel protein UpI from the sea anemone Urticina piscivora. Pharmacol Res 32:309–314

    Article  PubMed  CAS  Google Scholar 

  • Condon RH, Decker MB, Purcell JE (2001) Effects of low dissolved oxygen on survival and asexual reproduction of scyphozoan polyps (Chrysaora quinquecirrha). Hydrobiologia 451:89–95

    Article  Google Scholar 

  • Condon RH, Duarte CM, Pitt KA et al (2013) Recurrent jellyfish blooms are a consequence of global oscillations. Proc Natl Acad Sci 110(3):1000–1005

    Article  PubMed  Google Scholar 

  • Cormier MJ, Hori K, Karkhanis YD et al (1973) Evidence for similar biochemical requirements for bioluminescence among the coelenterates. J Cell Physiol 81:291

    Article  PubMed  CAS  Google Scholar 

  • Cormier MJ, Hori K, Anderson JM (1974) Bioluminescence in coelenterates. Biochim Biophys Acta 346(2):137–164

    Article  PubMed  CAS  Google Scholar 

  • Crone HD, Keen TEB (1969) Chromatographic properties of the hemolysin from the cnidarian Chironex fleckeri. Toxicon 7:79–87

    Article  PubMed  CAS  Google Scholar 

  • Cruz-Rivera E, El-Regal MA (2016) A bloom of an edible scyphozoan jellyfish in the Red Sea. Mar Biodivers 46(2):515–519

    Article  Google Scholar 

  • da Silva Barth C, Tolentino de Souza HG, Rocha LW et al (2017) Ipomoea pes-caprae (L.) R. Br (Convolvulaceae) relieved nociception and inflammation in mice—a topical herbal medicine against effects due to cnidarian venom-skin contact. J Ethnopharmacol 200:156–164

    Article  PubMed  CAS  Google Scholar 

  • Daly NL, Seymour J, Wilson D (2014) Exploring the therapeutic potential of jellyfish venom. Future Med Chem 6(15):1715–1724

    Article  PubMed  CAS  Google Scholar 

  • Dar MA, El-Wahab MA (2005) The coastal alterations due to the artificial lagoons, Red Sea “case study”. Egypt J Aquat Res 31:57–68 Special Issue

    Google Scholar 

  • Davenport D, Nicol JAC (1955) Luminescence of hydromedusae. Proc R Soc B 144:399–411

    Article  Google Scholar 

  • Dawson MN, Hamner WM (2003) Geographic variation and behavioral evolution in marine plankton: the case of Mastigias (Scyphozoa: Rhizostomeae). Mar Biol 143:1161–1174

    Article  Google Scholar 

  • Dawson MN, Hamner WM (2009) A character-based analysis of the evolution of jellyfish blooms: adaptation and exaptation. Hydrobiologia 616:193–215

    Article  Google Scholar 

  • Dawson MN, Martin LE, Penland LK (2001) Jellyfish swarms, tourists, and the Christ-child. Hydrobiologia 451:131–144

    Article  Google Scholar 

  • De Donno A, Idolo A, Bagordo F et al (2014) Impact of stinging jellyfish proliferations along South Italian coasts: human health hazards, treatment and social costs. Int J Environ Res Public Health 11:2488–2503

    Article  PubMed  PubMed Central  Google Scholar 

  • Decker MB, Breitberg DL, Purcell JE (2004) Effects of low dissolved oxygen on zooplankton predation by the ctenophore Mnemiopsis leidyi. Mar Ecol Prog Ser 280:163–172

    Article  Google Scholar 

  • DeClerck MP, Bailey Y, Craig D et al (2016) Efficacy of topical treatments for Chrysaora chinensis species: a human model in comparison with an in vitro model. Wilderness Environ Med 27:25–38

    Article  PubMed  Google Scholar 

  • Del Pozo LJ, Knöpfel N, Martín-Santiago A et al (2016) Dermoscopic findings of jellyfish stings caused by Pelagia noctiluca. Actas Dermosifiliogr 107(6):509–515

    Article  PubMed  Google Scholar 

  • Ding FY, Cheng JH (2005) The analysis on fish stock characteristics in the distribution areas of large jellyfish during summer and autumn in the East China Sea region. Mar Fisheries 27(2):120–128

    Google Scholar 

  • Ding F, Cheng J (2007) Dynamic distribution of Stomolophus meleagris in the East China Sea Region. J Fish Sci China 14:83–89 (in Chinese)

    Google Scholar 

  • Dong Z, Liu D, Keesing JK (2010) Jellyfish blooms in China: dominant species, causes and consequences. Mar Pollut Bull 60(7):954–963

    Article  PubMed  CAS  Google Scholar 

  • Doyle TK, De Haas H, Cotton D et al (2008) Widespread occurrence of the jellyfish Pelagia noctiluca in Irish coastal and shelf waters. J Plankton Res 30(8):963–968

    Article  Google Scholar 

  • Doyle TK, Headlam JL, Wilcox CL et al (2017) Evaluation of Cyanea capillata sting management protocols using ex vivo and in vitro envenomation models. Toxins 9:215

    Article  PubMed Central  Google Scholar 

  • Drazen JC, Robison BH (2004) Direct observations of the association between a deep-sea fish and a giant scyphomedusa. Mar Freshw Behav Physiol 37(3):209–214

    Article  Google Scholar 

  • Duarte CM, Pitt KA, Lucas CH et al (2013) Is global ocean sprawl a cause of jellyfish blooms? Front Ecol Environ 11(2):91–97

    Article  Google Scholar 

  • Dupont N, Aksnes DL (2010) Simulation of optically conditioned retention and mass occurrences of Periphylla periphylla. J Plankton Res 32(6):773–783

    Article  PubMed  PubMed Central  Google Scholar 

  • Eakin CM, Morgan JA, Heron SF et al (2010) Caribbean corals in crisis: record thermal stress, bleaching, and mortality in 2005. PLoS One 5(11):e13969

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Elshamy AI, El-Kashak WA, Abdallah HMI et al (2017) Soft coral Cespitularia stolonifera: New cytotoxic ceramides and gastroprotective activity. Chin J Nat Med 15(2):105–114

    PubMed  Google Scholar 

  • Fenner PJ, Fitzpatrick PF (1986) Experiments with the nematocysts of Cyanea capillata. Med J Aust 145:174

    PubMed  CAS  Google Scholar 

  • Fleming NEC, Harrod C, Griffin DC et al (2014) Scyphozoan jellyfish provide short-term reproductive habitat for hyperiid amphipods in a temperate near-shore environment. Mar Ecol Prog Ser 510:229–240

    Article  Google Scholar 

  • Fosså JH (1992) Mass occurrence of Periphylla periphylla (Scyphozoa, Coronatae) in a Norwegian fjord. Sarsia 77(3–4):237–251

    Article  Google Scholar 

  • Fu J, Koo K, Sang AX, Shisler DC (2014) Jellyfish envenomation in an ocean swimmer. Intern Emerg Med 9:103–104

    Article  PubMed  Google Scholar 

  • Furnestin ML (1959) Méduses du plancton marocain. Rev Trav Inst Scient Tech Pêches Marit 23(1):105–124

    Google Scholar 

  • Galil BS (1993) Lessepsian migration: new findings on the foremost anthropogenic change in the Levant basin fauna. In: Della Croce N (ed) Symposium Mediterranean seas 2000. Santa Margherita Ligure, 23–27 Sept 1991. Istituto Scienze Ambientali Marine, pp 307–318

    Google Scholar 

  • Galil BS, Spanier E, Ferguson WW (1990) The Scyphomedusae of the Mediterranean coast of Israel, including two Lessepsian migrants new to the Mediterranean. Zoologische Mededelingen 64:95–105

    Google Scholar 

  • Galil BS, Gershwin LA, Douek J et al (2010) Marivagia stellata gen. et sp. nov. (Scyphozoa: Rhizostomeae: Cepheidae), another alien jellyfish from the Mediterranean coast of Israel. Aquat Invasions 5(4):331–340

    Article  Google Scholar 

  • Galil BS, Gershwin LA, Zorea M et al (2017) Cotylorhiza erythraea Stiasny, 1920 (Scyphozoa: Rhizostomeae: Cepheidae), yet another erythraean jellyfish from the Mediterranean coast of Israel. Mar Biodivers 47(1):229–235

    Article  Google Scholar 

  • García-Linares S, Rivera-de-Torre E, Morante K et al (2016) Differential effect of membrane composition on the pore-forming ability of four different sea anemone actinoporins. Biochemistry 55:6630–6641

    Article  PubMed  CAS  Google Scholar 

  • Gibbs CR, Corkeron M, Blake DF (2014) Vinegar and Chironex fleckeri stings. Diving Hyperb Med 44(2):102

    PubMed  Google Scholar 

  • Glatstein M, Adir D, Galil B et al (2017) Pediatric jellyfish envenomation in the Mediterranean Sea. Eur J Emerg Med. doi: https://doi.org/10.1097/MEJ.0000000000000479

  • Gordoa A, Acuña JL, Farrés R et al (2013) Burst feeding of Pelagia noctiluca ephyrae on Atlantic bluefin tuna (Thunnus thynnus) eggs. PLoS One 8(9):e74721

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Goy J (1973) Gonionemus suvaensis: structural characters, developmental stages and ecology. Publ Seto Mar Biol Lab 20:525–536

    Article  Google Scholar 

  • Graham WM, Bayha KM (2008) Biological invasions by marine jellyfish. In: Nentwig W (ed) Biological invasions. Springer, Berlin, pp 239–255

    Google Scholar 

  • Graham WM, Martin DL, Felder DL et al (2003) Ecological and economic implications of a tropical jellyfish invader in the Gulf of Mexico. Biol Invasions 5:53–69

    Article  Google Scholar 

  • Greenwood PG (2009) Acquisition and use of nematocysts by cnidarian predators. Toxicon 54:1065–1070

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Guan S, Zhang P-G, Liu C-Y et al (2004) Pond cultivation state, existing problem and successful example of Rhopilema esculenta of Liaoning Province (in Chinese). Fish Sci 23(8):30–31

    Google Scholar 

  • Gülşahin N (2013) Muğla neritik bölgesi Scyphozoa (Cnidaria) ve Ctenophora türlerinin bolluk, dağılım ve biyomas özellikleri. PhD, Muğla Sıtkı Koçman University, Muğla, Turkey (in Turkish).

    Google Scholar 

  • Gülşahin N (2016) Preliminary study on nematocyst types and venom isolation of Cassiopea andromeda Forskål, 1775 (Scyphozoa, Cnidaria) from Turkey. CNS Agents Med Chem 16(3):208–212

    Google Scholar 

  • Gülşahin N (2017) Jellyfish blooms and injuries in Turkey. In: Mariottini GL (ed) Jellyfish: ecology, distribution patterns and human interactions. Nova Science Publishers, New York, pp 149–162

    Google Scholar 

  • Haddad V Jr (2013) Environmental dermatology: skin manifestations of injuries caused by invertebrate aquatic animals. An Bras Dermatol 88(4):496–506

    Article  PubMed  Google Scholar 

  • Haddock SH, Moline MA, Case JF (2009) Bioluminescence in the sea. Annu Rev Marine Sci 2(1):443–493

    Article  Google Scholar 

  • Halpern BS, Walbridge S, Selkoe KA et al (2008) A global map of human impact on marine ecosystems. Science 319:948–952

    Article  PubMed  CAS  Google Scholar 

  • Hamann CR, Hamann D, Richardson C et al (2014) Box jellyfish envenomation: case report of effective lemon and oil emulsion treatment. Trop Dr 44(2):106–107

    Google Scholar 

  • Hamner WM, Dawson MN (2009) A review and synthesis on the systematics and evolution of jellyfish blooms: advantageous aggregations and adaptive assemblages. Hydrobiologia 616(1):161–191

    Article  Google Scholar 

  • Hastings JW, Morin JG (1969) Calcium-triggered light emission in Renilla. A unitary biochemical scheme for coelenterate bioluminescence. Biochem Biophys Res Commun 37(3):493–498

    Article  PubMed  CAS  Google Scholar 

  • Heeger T, Piatkowski U, Möller H (1992) Predation of jellyfish by the cephalopod Argonauta argo. Mar Ecol Prog Ser 88:293–296

    Article  Google Scholar 

  • Helmholz H, Ruhnau C, Schütt C et al (2007) Comparative study on the cell toxicity and enzymatic activity of two northern scyphozoan species Cyanea capillata (L.) and Cyanea lamarckii (Péron & Léslieur). Toxicon 50:53–64

    Article  PubMed  CAS  Google Scholar 

  • Helmholz H, Wiebring A, Lassen S et al (2012) Cnidom analysis combined with an in vitro evaluation of the lytic, cyto- and neurotoxic potential of Cyanea capillata (Cnidaria: Scyphozoa). Sci Mar 76:339–348

    Article  CAS  Google Scholar 

  • Herring PJ, Widder EA (2004) Bioluminescence of deep-sea coronate medusae (Cnidaria: Scyphozoa). Mar Biol 146(1):39–51

    Article  Google Scholar 

  • Hessinger DA, Lenhoff HM (1973a) Binding of active and inactive hemolytic factor of sea anemone nematocyst venom to red blood cells. Biochem Biophys Res Commun 53:475–481

    Article  PubMed  CAS  Google Scholar 

  • Hessinger DA, Lenhoff HM (1973b) Assay and properties of the hemolysis activity of pure venom from the nematocysts of the acontia of the sea anemone Aiptasia pallida. Arch Biochem Biophys 159:629–638

    Article  CAS  Google Scholar 

  • Hessinger DA, Lenhoff HM (1976) Membrane structure and function. Mechanism of hemolysis induced by nematocyst venom: Roles of phospholipase A and direct lytic factor. Arch Biochem Biophys 173:603–613

    Article  PubMed  CAS  Google Scholar 

  • Hofmann DK, Kremer BP (1981) Carbon metabolism and strobilation in Cassiopea andromeda (Cnidaria: Scyphozoa): significance of endosymbiotic dinoflagellates. Mar Biol 65:25–33

    Article  CAS  Google Scholar 

  • Hofmann DK, Fitt WK, Fleck J (1996) Checkpoints in the life cycle of Cassiopea spp.: control of metagenesis and metamorphosis in a tropical jellyfish. Int J Dev Biol 40:331–338

    PubMed  CAS  Google Scholar 

  • Honeycutt JD, Jonas CE, Smith RF (2014) Treatment of jellyfish envenomation. Am Fam Physician 89(10):823A–823C

    Google Scholar 

  • Horiike T, Nagai H, Kitani S (2015) Identification of allergens in the box Jellyfish Chironex yamaguchii that cause sting dermatitis. Int Arch Allergy Immunol 167:73–82

    Article  PubMed  CAS  Google Scholar 

  • Hornbeak KB, Auerbach PS (2017) Marine envenomation. Emerg Med Clin North Am 35:321–337

    Article  PubMed  Google Scholar 

  • Houghton JD, Doyle TK, Wilson MW et al (2006) Jellyfish aggregations and leatherback turtle foraging patterns in a temperate coastal environment. Ecology 87(8):1967–1972

    Article  PubMed  Google Scholar 

  • Hsieh YP, Leong F-M, Rudloe J (2001) Jellyfish as food. Hydrobiologia 451:11–17

    Article  Google Scholar 

  • Humes AG (1969) A cyclopoid copepod, Sewellochiron fidens n. gen., n. sp., associated with a medusa in Puerto Rico. Beaufortia 16:171–183

    Google Scholar 

  • IPCC (2014) Climate change 2014: impacts, adaptation, and vulnerability. In: Field CB, Barros VR, Dokken DJ et al (ed) Part A: global and sectoral aspects contribution of working group II to the fifth assessment report of the Intergovernmental Panel on Climate Change

    Google Scholar 

  • Isbister GK, Palmer DJ, Weir RL et al (2017) Hot water immersion v icepacks for treating the pain of Chironex fleckeri stings: a randomised controlled trial. Med J Aust 206(6):258–261

    Article  PubMed  Google Scholar 

  • Ishii T, Kamada T, Vairappan CS (2016) Three new cembranoids from the Bornean soft coral Nephthea sp. J Asian Nat Prod Res 18(5):415–422

    Article  PubMed  CAS  Google Scholar 

  • Jackson JBC, Kirby MX, Berger WH et al (2001) Historical overfishing and the recent collapse of coastal ecosystems. Science 293:629–638

    Article  PubMed  CAS  Google Scholar 

  • Jarms G, Morandini A, da Silveira F (2002) Cultivation of polyps and medusae of Coronatae (Cnidaria, Scyphozoa) with a brief review of important characters. Helgol Mar Res 56(3):203

    Article  Google Scholar 

  • Jiang X, Chen H, Yang W et al (2003) Functional expression and characterization of an acidic actinoporin from sea anemone Sagartia rosea. Biochem Biophys Res Commun 312:562–570

    Article  PubMed  CAS  Google Scholar 

  • Jouiaei M, Casewell NR, Yanagihara AA et al (2015a) Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom. Toxins 7:936–950

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jouiaei M, Yanagihara AA, Madio B et al (2015b) Ancient venom systems: a review on Cnidaria toxins. Toxins 7:2251–2271

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kajfasz P (2015) A case of severe stinging caused by venomous marine animal, “Portuguese man of war” (Physalia species) in all probability. Int Marit Health 66(2):84–86

    Article  PubMed  Google Scholar 

  • Kang C, Munawir A, Cha M et al (2009) Cytotoxicity and hemolytic activity of jellyfish Nemopilema nomurai (Scyphozoa: Rhizostomeae) venom. Comp Biochem Physiol C 150:85–90

    Google Scholar 

  • Kang C, Jin YB, Kwak J et al (2013) Protective effect of tetracycline against dermal toxicity induced by jellyfish venom. PLoS One 8(3):e57658

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kang C, Han D-Y, Park K-I et al (2014) Characterization and neutralization of Nemopilema nomurai (Scyphozoa: Rhizostomeae) jellyfish venom using polyclonal antibody. Toxicon 86:116–125

    Article  PubMed  CAS  Google Scholar 

  • Karling TG (1966) On nematocysts and similar structures in turbellarians. Acta Zool Fenn 116:1–21

    Google Scholar 

  • Karthikayalu S, Rama V, Kirubagaran R et al (2010) Hemolytic toxin from the soft coral Sarcophyton trocheliophorum: Isolation and physiological characterization. J Venom Anim Toxins 16:107–120

    Article  CAS  Google Scholar 

  • Kawahara M, Uye S-I, Ohtsu K et al (2006) Unusual population explosion of the giant Jellyfish Nemopilema nomurai (Scyphozoa: Rhizostomeae) in East Asian waters. Mar Ecol Prog Ser 307:161–173

    Article  Google Scholar 

  • Keen TEB (1972) Surface properties of the hemolytic fraction derived from tentacles extracts of Chironex fleckeri. Toxicon 10:587–596

    Article  PubMed  CAS  Google Scholar 

  • Keen TEB, Crone HD (1969) The hemolytic properties of extracts of tentacles from the cnidarian Chironex fleckeri. Toxicon 7:55–63

    Article  PubMed  CAS  Google Scholar 

  • Kikinger R (1992) Cotylorhiza tuberculata (Cnidaria: Scyphozoa)—life history of a stationary population. Mar Ecol 13(4):333–362

    Article  Google Scholar 

  • Kitatani R, Yamada M, Kamio M et al (2015) Length is associated with pain: Jellyfish with painful sting have longer nematocyst tubules than harmless jellyfish. PLoS One 10(8):e0135015

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kitt W, Costley K (1998) The role of temperature in survival of the polyp stage of the tropical rhizostome jellyfish Cassiopea xamachana. J Exp Mar Biol Ecol 222:79–91

    Article  Google Scholar 

  • Knittel PS, Long PF, Brammall L et al (2016) Characterising the enzymatic profile of crude tentacle extracts from the South Atlantic jellyfish Olindias sambaquiensis (Cnidaria: Hydrozoa). Toxicon 119:1–7

    Article  PubMed  CAS  Google Scholar 

  • Kohl AC, Kerr RG (2003) Pseudopterosin biosynthesis: Aromatization of the diterpene cyclase product, Elisabethatriene. Mar Drugs 1:54–65

    Article  PubMed Central  CAS  Google Scholar 

  • La Spada G, Marino A, Sorrenti G (2002) Pelagia noctiluca “blooming” in the Strait of Messina: preliminary studies on the applicability of two methods for isolating nematocytes. Mar Ecol 23(s1):220–227

    Article  Google Scholar 

  • Lakkis NA, Maalouf GJ, Mahmassani DM (2015) Jellyfish stings: a practical approach. Wilderness Environ Med 26(3):422–429

    Article  PubMed  Google Scholar 

  • Larson RJ (1987) A note on the feeding, growth, and reproduction of the epipelagic scyphomedusa Pelagia noctiluca (Forskål). Biol Oceanogr 4(4):447–454

    Google Scholar 

  • Lassen S, Helmholz H, Ruhnau C et al (2011) A novel proteinaceous cytotoxin from the northern Scyphozoa Cyanea capillata (L.) with structural homology to cubozoan haemolysins. Toxicon 57:721–729

    Article  PubMed  CAS  Google Scholar 

  • Leone A, Lecci RM, Durante M et al (2013) Extract from the zooxanthellate jellyfish Cotylorhiza tuberculata modulates gap junction intercellular communication in human cell cultures. Mar Drugs 11:1728–1762

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li L, McGee RG, Isbister GK et al (2013) Interventions for the symptoms and signs resulting from jellyfish stings. Cochrane Database Syst Rev 12:CD009688

    Google Scholar 

  • Li R, Yu H, Yue Y et al (2014) In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris. Toxicon 92:60–65

    Article  PubMed  CAS  Google Scholar 

  • Li L, McGee RG, Webster AC (2015) Pain from bluebottle jellyfish stings. J Paediatr Child Health 51:734–737

    Article  PubMed  Google Scholar 

  • Li C, La M-P, Tang H et al (2016) Chemistry and bioactivity of briaranes from the South China Sea gorgonian Dichotella gemmacea. Mar Drugs 14:201

    Article  PubMed Central  CAS  Google Scholar 

  • Li Z, Tan X, Yu B et al (2017) Allergic shock caused by ingestion of cooked jellyfish. A case report. Medicine 96(38):e7962

    Article  PubMed  PubMed Central  Google Scholar 

  • Liew YJ, Soh WT, Jiemy WF et al (2015) Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata. Toxins 7(2):407–422

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Little M, Fitzpatrick R, Seymour J (2016) Successful use of heat as first aid for tropical Australian jellyfish stings. Toxicon 122:142–144

    Article  PubMed  CAS  Google Scholar 

  • Liu X (2008) North China Power 24:66–69 (in Chinese)

    Google Scholar 

  • Lo W, Purcell JE, Hung J et al (2008) Enhancement of jellyfish (Aurelia aurita) populations by extensive aquaculture rafts in a coastal lagoon in Taiwan. ICES J Mar Sci 65:453–461

    Article  Google Scholar 

  • Long KO, Burnett JW (1989) Isolation, characterization, and comparison of hemolytic peptides in nematocyst venoms of two species of jellyfish (Chrysaora quinquecirrha and Cyanea capillata). Comp Biochem Physiol B 94:641–646

    Article  Google Scholar 

  • Lu J (2009) Peninsula city newspaper 2009-7-8 (A8) (in Chinese)

    Google Scholar 

  • Lu N, Liu CY, Guo P (1989) Effect of salinity on larva of edible medusae (Rhopilema esculentum) at different development phases and a review on the cause of jellyfish resources falling greatly in Liaodong Bay. Acta Ecol Sin 4:304–309 (in Chinese)

    Google Scholar 

  • Lu Z, Dai Q, Yan Y (2003) Fishery biology of Cyanea nozakii resources in the waters of Dongshan Island. Chin J Appl Ecol 14:973–976 (in Chinese)

    Google Scholar 

  • Lucas CH, Gelcich S, Uye S-I (2014) Living with jellyfish: management and adaptation strategies. In: Pitt KA, Lucas CH (eds) Jellyfish blooms. Springer Science+Business Media, Dordrecht, pp 129–150

    Chapter  Google Scholar 

  • Macek P, Lebez D (1981) Kinetics of hemolysis induced by equinatoxin, a cytolytic toxin from the sea anemone Actinia equina. Effect of some ions and pH. Toxicon 19:233–240

    Article  PubMed  CAS  Google Scholar 

  • Macek P, Lebez D (1988) Isolation and characterization of three lethal and hemolytic toxins from the sea anemone Actinia equina L. Toxicon 26:441–451

    Article  PubMed  CAS  Google Scholar 

  • Maisano M, Trapani MR, Parrino V et al (2013) Haemolytic activity and characterization of nematocyst venom from Pelagia noctiluca (Cnidaria: Scyphozoa). Ital J Zool 80:168–176

    Article  CAS  Google Scholar 

  • Malej A, Faganeli J, Pezdič J (1993) Stable isotope and biochemical fractionation in the marine pelagic food chain: the jellyfish Pelagia noctiluca and net zooplankton. Mar Biol 116(4):565–570

    Article  CAS  Google Scholar 

  • Malve H (2016) Exploring the ocean for new drug developments: marine pharmacology. J Pharm Bioallied Sci 8(2):83–91

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mamish S, Durgham H, AL-Masri MS (2016) First record of the new alien sea jelly species Marivagia stellata Galil and Gershwin, 2010 off the Syrian coast. Mar Biodivers Rec 9(1):23

    Article  Google Scholar 

  • Manabe Y, Mabuchi T, Kawai M et al (2014) A case of delayed flare-up allergic dermatitis cause by jellyfish sting. Tokai J Exp Clin Med 39(3):90–94

    PubMed  Google Scholar 

  • Mao C, Hsu C-C, Chen K-T (2016) Ocular jellyfish stings: report of 2 cases and literature review. Wilderness Environ Med 27:421–424

    Article  PubMed  Google Scholar 

  • Marcogliese DJ (1995) The role of zooplankton in the transmission of helminth parasites to fish. Rev Fish Biol Fish 5:336–371

    Article  Google Scholar 

  • Marcogliese DJ (2002) Food webs and the transmission of parasites to marine fish. Parasitology 124:S83–S89

    Article  PubMed  Google Scholar 

  • Marino A, Crupi R, Rizzo G et al (2007) The unusual toxicity and stability properties of crude venom from isolated nematocysts of Pelagia noctiluca. Cell Mol Biol 53:994–1002

    Google Scholar 

  • Marino A, Morabito R, Pizzata T et al (2008) Effect of various factors on Pelagia noctiluca (Cnidaria, Scyphozoa) crude venom-induced haemolysis. Comp Biochem Physiol A Mol Integr Physiol 151(1):144–149

    Article  PubMed  CAS  Google Scholar 

  • Marino A, Morabito R, La Spada G (2009a) Factors altering the haemolytic power of crude venom from Aiptasia. mutabilis (Anthozoa) nematocysts. Comp Biochem Physiol A 152:418–422

    Article  CAS  Google Scholar 

  • Marino A, Morabito R, La Spada G (2009b) Toxicity of crude venom from the Scyphozoan Pelagia noctiluca. Comp Biochem Physiol A 154:30

    Article  Google Scholar 

  • Marino A, Morabito R, La Spada G (2013) Physiology of nematocytes. In: Proceedings of the 83th National Congress of the Italian Society for Experimental Biology (Società Italiana di Biologia Sperimentale—SIBS), Palermo, Italy, 24–25 Oct 2013. Abstract No 36

    Google Scholar 

  • Mariottini GL (2014) Hemolytic venoms from marine cnidarian jellyfish. An overview. J Venom Res 5:22–32

    PubMed  PubMed Central  Google Scholar 

  • Mariottini GL, Grice ID (2016) Antimicrobials from cnidarians. A new perspective for anti-infective therapy? Mar Drugs 14:48

    Article  PubMed Central  CAS  Google Scholar 

  • Mariottini GL, Pane L (2010) Mediterranean jellyfish venoms: a review on Scyphomedusae. Mar Drugs 8:1122–1152

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mariottini GL, Pane L (2014) Cytotoxic and cytolytic cnidarian venoms. A review on health implications and possible therapeutic applications. Toxins 6:108–151

    Article  CAS  Google Scholar 

  • Mariottini GL, Giacco E, Pane L (2008) The Mauve Stinger Pelagia noctiluca (Forsskål, 1775). Distribution, ecology, toxicity and epidemiology of stings. A review. Mar Drugs 6:496–513

    PubMed  PubMed Central  CAS  Google Scholar 

  • Mariscal RN (1974) Nematocysts. In: Muscatine L, Lenhoff HM (eds) Coelenterate biology. Academic Press, New York, pp 129–178

    Chapter  Google Scholar 

  • Matsueda N (1969) Presentation of Aurelia aurita at thermal power station. Bull Mar Biol Stat Asamushi 13:187–191

    Google Scholar 

  • Mayer AG (1910) Medusae of the World, III: the Scyphomedusae. Carnegie Institute, Washington, DC

    Google Scholar 

  • Mazzei M, Allavena A, Garzoglio R et al (1995) Chemical and chromatographic characteristics of toxin from the jellyfish Rhizostoma pulmo Agassiz (Cnidaria: Scyphozoa). Pharmacol Toxicol 76:38

    Google Scholar 

  • Merceron M, Le Fevre-Lehoerff G, Bizouarn Y et al (1995) Fish and jellyfish in Brittany (France). Equinoxe 56:6–8

    Google Scholar 

  • Miyamoto T, Yamada K, Ikeda N et al (1994) Bioactive terpenoids from Octocorallia, I. Bioactive diterpenoids: Litophynols A and B from the mucus of the soft coral Litophyton sp. J Nat Prod 57:1212–1219

    Article  PubMed  CAS  Google Scholar 

  • Miyazato H, Taira J, Ueda K (2016) Hydrogen peroxide derived from marine peroxy sesquiterpenoids induces apoptosis in HCT116 human colon cancer cells. Bioorg Med Chem Lett 26:4641–4644

    Article  PubMed  CAS  Google Scholar 

  • Mohd Suan MA, Tan WL, Soelar SA et al (2016) Jellyfish stings on Langkawi Island, Malaysia. Med J Malaysia 71(4):161–165

    PubMed  CAS  Google Scholar 

  • Montgomery L, Seys J, Mees J (2016) To pee, or not to pee: a review on envenomation and treatment in european jellyfish species. Mar Drugs 14:127

    Article  PubMed Central  CAS  Google Scholar 

  • Moore RE, Scheuer PJ (1971) Palytoxin: a new marine toxin from a Coelenterate. Science 172:495–498

    Article  PubMed  CAS  Google Scholar 

  • Morabito R, Condello S, Currò M et al (2012) Oxidative stress induced by crude venom from the jellyfish Pelagia noctiluca in neuronal-like differentiated SH-SY5Y cells. Toxicol in Vitro 26:694–699

    Article  PubMed  CAS  Google Scholar 

  • Morabito R, Marino A, Dossena S et al (2014a) Nematocyst discharge in Pelagia noctiluca (Cnidaria, Scyphozoa) oral arms can be affected by lidocaine, ethanol, ammonia and acetic acid. Toxicon 83:52–58

    Article  PubMed  CAS  Google Scholar 

  • Morabito R, Dossena S, La Spada G et al (2014b) Heavy metals affect nematocysts discharge response and biological activity of crude venom in the jellyfish Pelagia noctiluca (Cnidaria, Scyphozoa). Cell Physiol Biochem 34:244–254

    Article  PubMed  CAS  Google Scholar 

  • Morabito R, Dossena S, La Spada G et al (2014c) Regulatory volume decrease in isolated nematocytes is affected by crude venom from the jellyfish Pelagia noctiluca. J Biol Res 87:4813

    Google Scholar 

  • Morabito R, Costa R, Rizzo V et al (2017) Crude venom from nematocysts of Pelagia noctiluca (Cnidaria: Scyphozoa) elicits a sodium conductance in the plasma membrane of mammalian cells. Sci Rep 7:41065

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Morin JG (1974) Coelenterate bioluminescence. In: Muscatine L, Lenhoff HM (eds) Coelenterate biology. Academic Press, New York, pp 397–438

    Chapter  Google Scholar 

  • Morin JG (1976) Probable functions of bioluminescence in the Pennatulacea (Cnidaria, Anthozoa). In: Mackie GO (ed) Coelenterate ecology and behavior. Plenum, New York, pp 629–638

    Chapter  Google Scholar 

  • Morin JG, Hastings JW (1971a) Biochemistry of the bioluminescence of colonial hydroids and other coelenterates. J Cell Physiol 77(3):305–311

    Article  PubMed  CAS  Google Scholar 

  • Morin JG, Hastings JW (1971b) Energy transfer in a bioluminescent system. J Cell Physiol 77(3):313–318

    Article  PubMed  CAS  Google Scholar 

  • Nagai H, Takuwa-Kuroda K, Nakao M et al (2002) A novel protein toxin from the deadly box jellyfish (sea wasp, habu-kurage) Chiropsalmus quadrigatus. Biosci Biotechnol Biochem 66:97–102

    Article  PubMed  CAS  Google Scholar 

  • Nicol JACJ (1958) Observations on luminescence in pelagic animals. J Mar Biol Assoc UK 37(3):705–752

    Google Scholar 

  • Nordesjö A (2016) Treatment of Lion’s Mane jellyfish stings—hot water immersion versus topical corticosteroids. Degree Project in Medicine. Programme in Medicine. The Sahlgrenska Academy. Supervisor: Kai Knudsen. Department of Anesthesia and Intensive Care Medicine, University of Gothenburg, Sweden, pp 1–24

    Google Scholar 

  • Ohtsuka S, Koike K, Lindsay D et al (2009) Symbionts of marine medusae and ctenophores. Plank Benth Res 4(1):1–13

    Article  Google Scholar 

  • Omori M, Nakano E (2001) Jellyfish fisheries in Southeast Asia. Hydrobiologia 451(1-3):19–26

    Article  Google Scholar 

  • Ostermayer DG, Koyfman A (2015) What is the most effective treatment for relieving the pain of a jellyfish sting? Ann Emerg Med 65(4):432–433

    Article  PubMed  Google Scholar 

  • Othman I, Eldila MT, Mustafa MR et al (1996) Studies on the jellyfish Carybdea rastoni. Toxicon 34:167–168

    Article  Google Scholar 

  • Ottuso P (2013) Aquatic dermatology: encounters with the denizens of the deep (and not so deep) a review. Part I: the invertebrates. Int J Dermatol 52:136–152

    Article  PubMed  Google Scholar 

  • Özbek S (2011) The cnidarian nematocyst: a miniature extracellular matrix within a secretory vesicle. Protoplasma 248:635–640

    Article  PubMed  Google Scholar 

  • Peach MB, Pitt KA (2005) Morphology of the nematocysts of the medusae of two scyphozoans, Catostylus mosaicus and Phyllorhiza punctata (Rhizostomeae): implications for capture of prey. Invertebr Biol 124:98–108

    Article  Google Scholar 

  • Peng LS, Zhang XQ (1999) Marine Information 8:25 (in Chinese)

    Google Scholar 

  • Piraino S, Aglieri G, Martell L et al (2014) Pelagia benovici sp. nov.(Cnidaria, Scyphozoa): a new jellyfish in the Mediterranean Sea. Zootaxa 3794(3):455–468

    Article  PubMed  Google Scholar 

  • Ponce García DP (2017) Transcriptomic, proteomic and biological analyses of venom proteins from two Chrysaora jellyfish. PhD Thesis, Department of Pharmacology and Therapeutics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, 15 Jun 2017

    Google Scholar 

  • Ponce D, Brinkman DL, Luna-Ramírez K et al (2015) Comparative study of the toxic effects of Chrysaora quinquecirrha (Cnidaria: Scyphozoa) and Chironex fleckeri (Cnidaria: Cubozoa) venoms using cell-based assays. Toxicon 106:57–67

    Article  PubMed  CAS  Google Scholar 

  • Ponce D, Brinkman DL, Potriquet J et al (2016) Tentacle transcriptome and venom proteome of the Pacific Sea Nettle, Chrysaora fuscescens (Cnidaria: Scyphozoa). Toxins 8:102

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Purcell JE (1992) Effects of predation by the scyphomedusan Chrysaora quinquecirrha on zooplankton populations in Chesapeake Bay, USA. Mar Ecol Prog Ser 87:65–76

    Article  Google Scholar 

  • Purcell JE (2005) Climate effects on formation of jellyfish and ctenophore blooms: a review. J Mar Biol Assoc UK 85:461–476

    Article  Google Scholar 

  • Purcell JE, Arai MN (2001) Interactions of pelagic cnidarians and ctenophores with fish: a review. Hydrobiologia 451:22–44

    Google Scholar 

  • Purcell JE, Båmstedt U, Båmstedt A (1999a) Prey, feeding rates, and asexual reproduction rates of the introduced oligohaline hydrozoan Moerisia lyonsi. Mar Biol 134:317–325

    Article  Google Scholar 

  • Purcell JE, Malej A, Benovic A (1999b) Potential links of jellyfish to eutrophication and fisheries. In: Malone TC, Malej A, Harding LW Jr, Smodlaka N, Turner RE (eds) Ecosystems at the land–sea margin: drainage basin to coastal sea. Coast Estuar Stud 55:241–263

    Article  Google Scholar 

  • Purcell JE, Uye S, Lo W (2007) Anthropogenic causes of jellyfish blooms and their direct consequences for humans: a review. Mar Ecol Prog Ser 350:153–174

    Article  Google Scholar 

  • Queruel P, Bernard P, Goy J et al (2000) Envenimations par la méduse Pelagia noctiluca sur nos côtes méditerranéennes. Presse Méd 29:188

    PubMed  Google Scholar 

  • Rahat M, Adar O (1980) Effect of symbiotic zooxanthellae and temperature on budding and strobilation in Cassiopea andromeda (Eschscholz). Biol Bull 159(3):394–401

    Article  Google Scholar 

  • Reimão JQ, Migotto AE, Kossuga MH et al (2008) Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei. Parasitol Res 103:1445–1450

    Article  PubMed  Google Scholar 

  • Richardson AJ, Bakun A, Hays GC et al (2009) The jellyfish joyride: causes, consequences and management responses to a more gelatinous future. Trends Ecol Evol 24:312–322

    Article  PubMed  Google Scholar 

  • Rivera-de-Torre E, Palacios-Ortega J, García-Linares S et al (2017) One single salt bridge explains the different cytolytic activities shown by actinoporins sticholysin I and II from the venom of Stichodactyla helianthus. Arch Biochem Biophys 636:79–89

    Article  PubMed  CAS  Google Scholar 

  • Robison BH (1983) Midwater biological research with the WASP ADS. Mar Technol Soc J 17:21–27

    Google Scholar 

  • Rogers CA, Biggs DC, Cooper RA (1978) Aggregation of the siphonophore Nanomia cara in the Gulf of Maine: observations from a submersible. Fish Bull 76:281–284

    Google Scholar 

  • Rottini G, Gusmani L, Parovel E et al (1995) Purification and properties of a cytolytic toxin in venom of the jellyfish Carybdea marsupialis. Toxicon 33:315–326

    Article  PubMed  CAS  Google Scholar 

  • Sabatés A, Pages F, Atienza D et al (2010) Planktonic cnidarian distribution and feeding of Pelagia noctiluca in the NW Mediterranean Sea. Hydrobiologia 645(1):153–165

    Article  Google Scholar 

  • Salleo A, La Spada G, Alfa M (1983) Blockage of trypsin-induced discharge of nematocysts of Pelagia noctiluca by Ca2+. Mol Physiol 3:89-97.

    Google Scholar 

  • Salleo A, La Spada G, Falzea G et al (1984a) Discharging effects of anions and inhibitory effect of divalent cations on isolated nematocysts of Pelagia noctiluca. Mol Physiol 5:25–34

    CAS  Google Scholar 

  • Salleo A, La Spada G, Falzea G et al (1984b) pH-induced collapse of the capsular wall in isolated nematocysts of Pelagia noctiluca. Cell Mol Biol 30:91–94

    PubMed  CAS  Google Scholar 

  • Salleo A, La Spada G, Falzea G et al (1984c) Discharging effectiveness of lyotropic anions on nematocysts of Pelagia noctiluca. Mol Physiol 6:19–26

    CAS  Google Scholar 

  • Salleo A, La Spada G, Denaro MG et al (1986) Effects produced by SCN- and thioglycolate on isolated nematocysts of Pelagia noctiluca. Cell Mol Biol 32:661–666

    PubMed  CAS  Google Scholar 

  • Salvanes AG, Utne-Palm AC, Currie B et al (2011) Behavioural and physiological adaptations of the bearded goby, a key fish species of the extreme environment of the northern Benguela upwelling. Mar Ecol Prog Ser 425:193–202

    Article  Google Scholar 

  • Sarà M (1991) Zoologia. Cacucci editore, Bari

    Google Scholar 

  • Schuchert P (2007) The hydrozoa directory, version 15, September 2007. http://www.ville-ge.ch/musinfo/mhng/hydrozoa/hydrozoa-directory.htm

  • Shein KA (2006) State of the climate in 2005. Bull Am Meteorol Soc 87(6):s1–s102

    Article  Google Scholar 

  • Shimomura O, Johnson FH, Saiga Y (1962) Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea. J Cell Physiol 59(3):223–239

    Article  CAS  Google Scholar 

  • Shoji J, Kudoh T, Takatsuji H et al (2010) Distribution of moon jellyfish Aurelia aurita in relation to summer hypoxia in Hiroshima Bay, Seto Inland Sea. Est Coast Shelf Sci 86:485–490

    Article  CAS  Google Scholar 

  • Sintsova ОV, Monastyrnaya ММ, Pislyagin EA et al (2015) Anti-inflammatory activity of a polypeptide from the Heteractis crispa sea anemone. Russ J Bioorg Chem 41(6):590–596

    Article  CAS  Google Scholar 

  • Stiasny G (1920) Die Scyphomedusen-Sammlung des Naturhistorischen Reichsmuseums in Leiden. III, Rhizostomae. Zoologische Mededelingen 5:213–230

    Google Scholar 

  • Stiasny G (1921) Studien über rhizostomeen. Capita Zoologica 1(VIII):1–179, 5 plates

    Google Scholar 

  • Su L (2007) Beijing Science and Technology Newspaper 2007-9-24 (in Chinese)

    Google Scholar 

  • Su Y-D, Su J-H, Hwang T-L et al (2017) Briarane diterpenoids isolated from octocorals between 2014 and 2016. Mar Drugs 15:44

    Article  PubMed Central  CAS  Google Scholar 

  • Tamkun MM, Hessinger DA (1981) Isolation and partial characterization of a hemolytic and toxic protein from the nematocyst venom of the Portuguese Man-of-War, Physalia physalis. Biochim Biophys Acta 667:87–98

    Article  PubMed  CAS  Google Scholar 

  • Thaikruea L, Siriariyaporn P (2015) Severe dermatonecrotic toxin and wound complications associated with box jellyfish stings 2008–2013. J Wound Ostomy Continence Nurs 42(6):599–604

    Article  PubMed  Google Scholar 

  • Thaikruea L, Siriariyaporn P (2016) The magnitude of severe box jellyfish cases on Koh Samui and Koh Pha-ngan in the Gulf of Thailand. BMC Res Notes 9:108

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Theoharides TC (1983) Mast cell secretion: basis for jellyfish poisoning and prospects for relief. Workshop on Jellyfish Blooms in the Mediterranean, Athens, 31 October–4 November 1983, pp 63–73

    Google Scholar 

  • Turan C, Gürlek M, Özbalcılar B et al (2011) Jellyfish bycatch data by purse-seine, trawl and net fisheries during March–April 2011 in the Mediterranean coasts of Turkey. In: Turan C, Öztürk B (eds) First National Workshop on Jellyfish and Other Gelatinous Species in Turkish Marine Waters (vol 5). 20–21 May 2011. Turkish Marine Research Foundation, İstanbul, pp 1–7

    Google Scholar 

  • Turk T, Macek P (1986) Effect of different membrane lipids on the hemolytic activity of equinatoxin II from Actinia equina. Period Biol 88:216–217

    CAS  Google Scholar 

  • UNEP (United Nations Environmental Programme) (1984) Workshop on jellyfish blooms in the Mediterranean. 31 Oct–4 Nov 1983, Athens:1–221

    Google Scholar 

  • UNEP (United Nations Environment Programme) (1991) Jellyfish blooms in the Mediterranean. Proceedings of the II Workshop on Jellyfish in the Mediterranean Sea. MAP Tech Rep Ser No.47. UNEP, Athens:1–320

    Google Scholar 

  • Uye SI (2008) Blooms of the giant jellyfish Nemopilema nomurai: a threat to the fisheries sustainability of the East Asian Marginal Seas. Plankton Benthos Res 3(Suppl):125–131

    Article  Google Scholar 

  • Uye S, Ueta U (2004) Recent increases of jellyfish populations and their nuisance to fisheries in the Inland Sea of Japan. Bull Jpn Soc Fish Oceanogr 68:9–19

    Google Scholar 

  • Vaikundamoorthy R, Sundaramoorthy R, Krishnamoorthy V et al (2016) Marine steroid derived from Acropora formosa enhances mitochondrial-mediated apoptosis in non-small cell lung cancer cells. Tumor Biol 37:10517–10531

    Article  CAS  Google Scholar 

  • Verde EA, McCloskey LR (1998) Production, respiration, and photophysiology of the mangrove jellyfish Cassiopea xamachana symbiotic with zooxanthellae: effect of jellyfish size and season. Mar Ecol Prog Ser 168:147–162

    Article  Google Scholar 

  • Vine P (1986) Red sea invertebrates. Immel Publishing, London

    Google Scholar 

  • Wampler JE, Hori K, Lee JW et al (1971) Structured bioluminescence. Two emitters during both the in vitro and the in vivo bioluminescence of the sea pansy, Renilla. Biochemistry 10:2903

    Article  PubMed  CAS  Google Scholar 

  • Wampler JE, Karkhanis YD, Morin JG et al (1973) Similarities in the bioluminescence from the Pennantulacea. Biochim Biophys Acta 314:104

    Article  PubMed  CAS  Google Scholar 

  • Wang T, Wen XJ, Mei XB et al (2013) Lipid peroxidation is another potential mechanism besides pore-formation underlying hemolysis of tentacle extract from the jellyfish Cyanea capillata. Mar Drugs 11:67–80

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang B, Liu D, Liu G et al (2015) Protective effects of batimastat against hemorrhagic injuries in delayed jellyfish envenomation syndrome models. Toxicon 108:232–239

    Article  PubMed  CAS  Google Scholar 

  • Ward MT, Darracq MA, Tomaszewski C et al (2012) Evidence-based treatment of jellyfish stings in North America and Hawaii. Ann Emerg Med 60(4):399–414

    Article  PubMed  Google Scholar 

  • Weill R (1934) Contribution à l’étude des cnidaires et de leurs nématocystes. Trav Stat Zool Wimereux 10/11:1–701

    Google Scholar 

  • Weinheimer AJ, Spraggins RL (1969) The occurrence of two new prostaglandin derivatives (15-epi-PGA2 and its acetate, methyl ester) in the Gorgonian Plexaura homomalla. Chemistry of Coelenterates. XV. Tetrahedron Lett 10:5185–5188

    Article  Google Scholar 

  • Welfare P, Little M, Pereira P et al (2014) An in-vitro examination of the effect of vinegar on discharged nematocysts of Chironex fleckeri. Diving Hyperb Med 44(1):30–34

    PubMed  Google Scholar 

  • Widder E (2002) Bioluminescence and the pelagic visual environment. Mar Freshw Behav Physiol 35(1–2):1–26

    Article  Google Scholar 

  • Widder EA (2010) Bioluminescence in the ocean: origins of biological, chemical, and ecological diversity. Science 328(5979):704–708

    Article  PubMed  CAS  Google Scholar 

  • Widder EA, Bernstein SA, Bracher DF et al (1989) Bioluminescence in the Monterey Submarine Canyon: image analysis of video recordings from a midwater submersible. Mar Biol 100(4):541–551

    Article  Google Scholar 

  • Widmer CL (2005) Effects of temperature on growth of north-east Pacific moon jellyfish ephyrae, Aurelia labiata (Cnidaria: Scyphozoa). J Mar Biol Assoc UK 85(3):569–573

    Article  Google Scholar 

  • Wilcox CL, Yanagihara AA (2016) Heated debates: Hot-water immersion or ice packs as first aid for cnidarian envenomations? Toxins 8:97

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilcox CL, Headlam JL, Doyle TK et al (2017) Assessing the efficacy of first aid measures in Physalia sp. envenomation, using solution- and blood agarose-based models. Toxins 9:149

    Article  PubMed Central  Google Scholar 

  • Wu B-L (1955) Hai Zhe (R. esculentum) (in Chinese). Sheng Wu Xue Tong Bao (Biol Newsl) 4:35–40

    Google Scholar 

  • Yanagihara AA, Chen JJ (2014) The effect of vinegar on discharged nematocysts of Chironex fleckeri. Diving Hyperb Med 44(3):172

    PubMed  Google Scholar 

  • Yanagihara AA, Wilcox CL (2017) Cubozoan sting-site seawater rinse, scraping, and ice can increase venom load: upending current first aid recommendations. Toxins 9:105

    Article  PubMed Central  CAS  Google Scholar 

  • Yanagihara AA, Wilcox C, King R et al (2016) Experimental assays to assess the efficacy of vinegar and other topical first-aid approaches on cubozoan (Alatina alata) tentacle firing and venom toxicity. Toxins 8:19

    Article  PubMed Central  CAS  Google Scholar 

  • Yao HY, Cho TH, Lu CH et al (2016) Hypertonic saline in the treatment of corneal jellyfish stings. J Travel Med 23(2):1–2. https://doi.org/10.1093/jtm/tav030

    Article  Google Scholar 

  • Yasuda T (2003) Marine UFO medusae: development, ecology and measures against impacts on human societies. Kouseisha-Kouseikaku, Tokyo, 206 pp. (in Japanese)

    Google Scholar 

  • Yılmaz IN (2015) Collapse of zooplankton stocks during Liriope tetraphylla (Hydromedusa) blooms and dense mucilaginous aggregations in a thermohaline stratified basin. Mar Ecol 36(3):595–610

    Article  Google Scholar 

  • You K, Ma C, Gao H et al (2007) Research on the jellyfish (Rhopilema esculentum Kishinouye) and associated aquaculture techniques in China: current status. Aquac Int 15(6):479–488

    Article  Google Scholar 

  • Yue Y, Yu H, Li R et al (2017) Functional elucidation of Nemopilema nomurai and Cyanea nozakii nematocyst venoms’ lytic activity using mass spectrometry and zymography. Toxins 9:47

    Article  PubMed Central  CAS  Google Scholar 

  • Zhong X, Tang J, Liu P (2003) A study on the relationship between Cyanea nozakii Kishinouye breaking out and ocean ecosystem. Mod Fish Inform 19:15–17 (in Chinese)

    Google Scholar 

  • Zhou T, Huang M (1956) Cyanea nozakii: a predator to commercial fishery species in Yellow and Bohai Sea. Biol Bull 6:9–12

    Google Scholar 

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Authors and Affiliations

  1. Faculty of Fisheries, Muğla Sitki Koçman University, Muğla, Turkey

    N. Killi

  2. Department of Earth, Environment and Life Sciences, University of Genova, Genova, Italy

    G. L. Mariottini

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  1. N. Killi
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  2. G. L. Mariottini
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Correspondence to G. L. Mariottini .

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Editors and Affiliations

  1. Houston Methodist Research Institute, Houston, Texas, USA

    Malgorzata Kloc

  2. Institute of Genetics and Development of Rennes, Université de Rennes, Rennes, France

    Jacek Z. Kubiak

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Killi, N., Mariottini, G.L. (2018). Cnidarian Jellyfish: Ecological Aspects, Nematocyst Isolation, and Treatment Methods of Sting. In: Kloc, M., Kubiak, J. (eds) Marine Organisms as Model Systems in Biology and Medicine. Results and Problems in Cell Differentiation, vol 65. Springer, Cham. https://doi.org/10.1007/978-3-319-92486-1_21

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