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Pathology of Renal Tumors

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Diagnosis and Surgical Management of Renal Tumors

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Abstract

Renal cell carcinoma (RCC) comprises a group of tumors that represent the most common malignant renal neoplasms. Several distinct subtypes of RCC exist, each characterized by unique morphologic, cytogenetic, molecular, and clinical characteristics. Aside from RCC, there are also several benign tumors that occur in the kidney, representing up to 20% of all renal cortical neoplasms. In this chapter we review the pathology of renal tumors.

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References

  1. (CAP) CoAP. Cancer protocol templates AJCC cancer staging manual 2016 [cited 2016 09/26/17]. Available from: www.cap.org/web/oracle/webcenter/portalapp/pagehierarchy/cancer_protocol_templates.jspx?_adf.ctrl-state=mgbufglyx_4&_afrLoop=50758928733115#!%40%40%3F_afrLoop%3D50758928733115%26_adf.ctrl-state%3D3jlqfweu7_4.

  2. Amin MB, Edge SB. In: Cancer AJCo, editor. AJCC cancer staging manual. Chicago: Springer; 2017.

    Chapter  Google Scholar 

  3. Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, et al. The International Society of Urological Pathology (ISUP) vancouver classification of renal neoplasia. Am J Surg Pathol. 2013;37(10):1469–89.

    Article  PubMed  Google Scholar 

  4. Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumours. Eur Urol. 2016;70(1):93–105.

    Article  PubMed  Google Scholar 

  5. Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, et al. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013;37(10):1490–504.

    Article  PubMed  Google Scholar 

  6. Przybycin CG, Magi-Galluzzi C, McKenney JK. Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimens. Adv Anat Pathol. 2013;20(4):245–63.

    Article  PubMed  Google Scholar 

  7. Escudier B, Porta C, Schmidinger M, Rioux-Leclercq N, Bex A, Khoo V, et al. Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(suppl 5):v58–68.

    Article  CAS  PubMed  Google Scholar 

  8. Pantuck AJ, Zisman A, Belldegrun AS. The changing natural history of renal cell carcinoma. J Urol. 2001;166(5):1611–23.

    Article  CAS  PubMed  Google Scholar 

  9. Bonsib SM. The renal sinus is the principal invasive pathway: a prospective study of 100 renal cell carcinomas. Am J Surg Pathol. 2004;28(12):1594–600.

    Article  PubMed  Google Scholar 

  10. Bonsib SM. Renal veins and venous extension in clear cell renal cell carcinoma. Mod Pathol. 2007;20(1):44–53.

    Article  PubMed  Google Scholar 

  11. Delahunt B, Bethwaite PB, Nacey JN. Outcome prediction for renal cell carcinoma: evaluation of prognostic factors for tumours divided according to histological subtype. Pathology. 2007;39(5):459–65.

    Article  CAS  PubMed  Google Scholar 

  12. Nguyen DP, Vertosick EA, Corradi RB, Vilaseca A, Benfante NE, Touijer KA, et al. Histological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomy. Urol Oncol. 2016;34(6):259.e1–8.

    Article  Google Scholar 

  13. Hirsch MS, Signoretti S, Dal Cin P. Adult renal cell carcinoma: a review of established entities from morphology to molecular genetics. Surg Pathol Clin. 2015;8(4):587–621.

    Article  PubMed  Google Scholar 

  14. Su D, Singer EA, Srinivasan R. Molecular pathways in renal cell carcinoma: recent advances in genetics and molecular biology. Curr Opin Oncol. 2015;27(3):217–23.

    Article  CAS  PubMed  Google Scholar 

  15. Reuter VE, Argani P, Zhou M, Delahunt B. Best practices recommendations in the application of immunohistochemistry in the kidney tumors: report from the International Society of Urologic Pathology consensus conference. Am J Surg Pathol. 2014;38(8):e35–49.

    Article  PubMed  Google Scholar 

  16. Tan PH, Cheng L, Rioux-Leclercq N, Merino MJ, Netto G, Reuter VE, et al. Renal tumors: diagnostic and prognostic biomarkers. Am J Surg Pathol. 2013;37(10):1518–31.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Zhou M, Roma A, Magi-Galluzzi C. The usefulness of immunohistochemical markers in the differential diagnosis of renal neoplasms. Clin Lab Med. 2005;25(2):247–57.

    Article  PubMed  Google Scholar 

  18. Zucchi A, Novara G, Costantini E, Antonelli A, Carini M, Carmignani G, et al. Prognostic factors in a large multi-institutional series of papillary renal cell carcinoma. BJU Int. 2012;109(8):1140–6.

    Article  PubMed  Google Scholar 

  19. Delahunt B, Egevad L, Samaratunga H, Martignoni G, Nacey JN, Srigley JR. Gleason and Fuhrman no longer make the grade. Histopathology. 2016;68(4):475–81.

    Article  PubMed  Google Scholar 

  20. Antonelli A, Tardanico R, Balzarini P, Arrighi N, Perucchini L, Zanotelli T, et al. Cytogenetic features, clinical significance and prognostic impact of type 1 and type 2 papillary renal cell carcinoma. Cancer Genet Cytogenet. 2010;199(2):128–33.

    Article  CAS  PubMed  Google Scholar 

  21. Bigot P, Bernhard JC, Gill IS, Vuong NS, Verhoest G, Flamand V, et al. The subclassification of papillary renal cell carcinoma does not affect oncological outcomes after nephron sparing surgery. World J Urol. 2016;34(3):347–52.

    Article  PubMed  Google Scholar 

  22. Cornejo KM, Dong F, Zhou AG, Wu CL, Young RH, Braaten K, et al. Papillary renal cell carcinoma: correlation of tumor grade and histologic characteristics with clinical outcome. Hum Pathol. 2015;46(10):1411–7.

    Article  PubMed  Google Scholar 

  23. Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, et al. Comprehensive molecular characterization of papillary renal-cell carcinoma. N Engl J Med. 2016;374(2):135–45.

    Article  PubMed  CAS  Google Scholar 

  24. Kovac M, Navas C, Horswell S, Salm M, Bardella C, Rowan A, et al. Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution. Nat Commun. 2015;6:6336.

    Article  CAS  PubMed  Google Scholar 

  25. Yang XJ, Tan MH, Kim HL, Ditlev JA, Betten MW, Png CE, et al. A molecular classification of papillary renal cell carcinoma. Cancer Res. 2005;65(13):5628–37.

    Article  CAS  PubMed  Google Scholar 

  26. Amin MB, Paner GP, Alvarado-Cabrero I, Young AN, Stricker HJ, Lyles RH, et al. Chromophobe renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases. Am J Surg Pathol. 2008;32(12):1822–34.

    Article  PubMed  Google Scholar 

  27. Gordetsky J, Zarzour J. Correlating preoperative imaging with histologic subtypes of renal cell carcinoma and common mimickers. Curr Urol Rep. 2016;17(7):52.

    Article  PubMed  Google Scholar 

  28. Volpe A, Novara G, Antonelli A, Bertini R, Billia M, Carmignani G, et al. Chromophobe renal cell carcinoma (RCC): oncological outcomes and prognostic factors in a large multicentre series. BJU Int. 2012;110(1):76–83.

    Article  PubMed  Google Scholar 

  29. Schmidt LS, Linehan WM. Molecular genetics and clinical features of Birt-Hogg-Dube syndrome. Nat Rev Urol. 2015;12(10):558–69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Ng KL, Morais C, Bernard A, Saunders N, Samaratunga H, Gobe G, et al. A systematic review and meta-analysis of immunohistochemical biomarkers that differentiate chromophobe renal cell carcinoma from renal oncocytoma. J Clin Pathol. 2016;69(8):661–71.

    Article  CAS  PubMed  Google Scholar 

  31. Abbosh P, Sundararajan S, Millis SZ, Hauben A, Reddy S, Geynisman DM, Uzzo R. Molecular and genomic profiling to identify actionable targets in chromophobe renal cell cancer. Eur Urol Focus. 2017. pii:S2405–4569(17)30008-1.

    Google Scholar 

  32. Alexiev BA, Drachenberg CB. Clear cell papillary renal cell carcinoma: incidence, morphological features, immunohistochemical profile, and biologic behavior: a single institution study. Pathol Res Pract. 2014;210(4):234–41.

    Article  CAS  PubMed  Google Scholar 

  33. Aydin H, Chen L, Cheng L, Vaziri S, He H, Ganapathi R, et al. Clear cell tubulopapillary renal cell carcinoma: a study of 36 distinctive low-grade epithelial tumors of the kidney. Am J Surg Pathol. 2010;34(11):1608–21.

    PubMed  Google Scholar 

  34. Diolombi ML, Cheng L, Argani P, Epstein JI. Do clear cell papillary renal cell carcinomas have malignant potential? Am J Surg Pathol. 2015;39(12):1621–34.

    Article  PubMed  Google Scholar 

  35. Gobbo S, Eble JN, Grignon DJ, Martignoni G, MacLennan GT, Shah RB, et al. Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entity. Am J Surg Pathol. 2008;32(8):1239–45.

    Article  PubMed  Google Scholar 

  36. Rohan SM, Xiao Y, Liang Y, Dudas ME, Al-Ahmadie HA, Fine SW, et al. Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol. 2011;24(9):1207–20.

    Article  CAS  PubMed  Google Scholar 

  37. Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, et al. Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol. 2006;30(2):141–53.

    Article  PubMed  Google Scholar 

  38. Wang K, Zarzour J, Rais-Bahrami S, Gordetsky J. Clear cell papillary renal cell carcinoma: new clinical and imaging characteristics. Urology. 2017;103:136–41.

    Article  PubMed  Google Scholar 

  39. Wolfe A, Dobin SM, Grossmann P, Michal M, Donner LR. Clonal trisomies 7,10 and 12, normal 3p and absence of VHL gene mutation in a clear cell tubulopapillary carcinoma of the kidney. Virchows Arch. 2011;459(4):457–63.

    Article  PubMed  Google Scholar 

  40. Zhou H, Zheng S, Truong LD, Ro JY, Ayala AG, Shen SS. Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. Hum Pathol. 2014;45(1):59–64.

    Article  PubMed  Google Scholar 

  41. Shah AY, Karam JA, Malouf GG, Rao P, Lim ZD, Jonasch E, et al. Management and outcomes of patients with renal medullary carcinoma: a multicentre collaborative study. BJU Int. 2016;120:782.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Gobbo S, Eble JN, Delahunt B, Grignon DJ, Samaratunga H, Martignoni G, et al. Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles. Am J Surg Pathol. 2010;34(5):620–6.

    PubMed  Google Scholar 

  43. Petersson F, Gatalica Z, Grossmann P, Perez Montiel MD, Alvarado Cabrero I, Bulimbasic S, et al. Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases. Virchows Arch. 2010;456(4):355–65.

    Article  PubMed  Google Scholar 

  44. Tickoo SK, Reuter VE, Amin MB, Srigley JR, Epstein JI, Min KW, et al. Renal oncocytosis: a morphologic study of fourteen cases. Am J Surg Pathol. 1999;23(9):1094–101.

    Article  CAS  PubMed  Google Scholar 

  45. Waldert M, Klatte T, Haitel A, Ozsoy M, Schmidbauer J, Marberger M, et al. Hybrid renal cell carcinomas containing histopathologic features of chromophobe renal cell carcinomas and oncocytomas have excellent oncologic outcomes. Eur Urol. 2010;57(4):661–5.

    Article  PubMed  Google Scholar 

  46. Pote N, Vieillefond A, Couturier J, Arrufat S, Metzger I, Delongchamps NB, et al. Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas. Virchows Arch. 2013;462(6):633–8.

    Article  CAS  PubMed  Google Scholar 

  47. Gonzalez-Roibon N, Albadine R, Sharma R, Faraj SF, Illei PB, Argani P, et al. The role of GATA binding protein 3 in the differential diagnosis of collecting duct and upper tract urothelial carcinomas. Hum Pathol. 2013;44(12):2651–7.

    Article  CAS  PubMed  Google Scholar 

  48. Kobayashi N, Matsuzaki O, Shirai S, Aoki I, Yao M, Nagashima Y. Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. Hum Pathol. 2008;39(9):1350–9.

    Article  CAS  PubMed  Google Scholar 

  49. Sui W, Matulay JT, Robins DJ, James MB, Onyeji IC, RoyChoudhury A, et al. Collecting duct carcinoma of the kidney: disease characteristics and treatment outcomes from the National Cancer Database. Urol Oncol. 2017;35(9):540.e13–8.

    Article  Google Scholar 

  50. Zambrano NR, Lubensky IA, Merino MJ, Linehan WM, Walther MM. Histopathology and molecular genetics of renal tumors toward unification of a classification system. J Urol. 1999;162(4):1246–58.

    Article  CAS  PubMed  Google Scholar 

  51. Elwood H, Chaux A, Schultz L, Illei PB, Baydar DE, Billis A, et al. Immunohistochemical analysis of SMARCB1/INI-1 expression in collecting duct carcinoma. Urology. 2011;78(2):474.e1–5.

    Article  Google Scholar 

  52. Ezekian B, Englum B, Gilmore BF, Nag UP, Kim J, Leraas HJ, et al. Renal medullary carcinoma: a national analysis of 159 patients. Pediatr Blood Cancer. 2017;64(11):e26609.

    Article  Google Scholar 

  53. Hakimi AA, Koi PT, Milhoua PM, Blitman NM, Li M, Hugec V, et al. Renal medullary carcinoma: the Bronx experience. Urology. 2007;70(5):878–82.

    Article  PubMed  Google Scholar 

  54. Swartz MA, Karth J, Schneider DT, Rodriguez R, Beckwith JB, Perlman EJ. Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications. Urology. 2002;60(6):1083–9.

    Article  PubMed  Google Scholar 

  55. Armah HB, Parwani AV. Xp11.2 translocation renal cell carcinoma. Arch Pathol Lab Med. 2010;134(1):124–9.

    PubMed  Google Scholar 

  56. Classe M, Malouf GG, Su X, Yao H, Thompson EJ, Doss DJ, et al. Incidence, clinicopathological features and fusion transcript landscape of translocation renal cell carcinomas. Histopathology. 2017;70(7):1089–97.

    Article  PubMed  Google Scholar 

  57. Ellis CL, Eble JN, Subhawong AP, Martignoni G, Zhong M, Ladanyi M, et al. Clinical heterogeneity of Xp11 translocation renal cell carcinoma: impact of fusion subtype, age, and stage. Mod Pathol. 2014;27(6):875–86.

    Article  CAS  PubMed  Google Scholar 

  58. Kauffman EC, Ricketts CJ, Rais-Bahrami S, Yang Y, Merino MJ, Bottaro DP, et al. Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. Nat Rev Urol. 2014;11(8):465–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Martignoni G, Pea M, Gobbo S, Brunelli M, Bonetti F, Segala D, et al. Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas. Mod Pathol. 2009;22(8):1016–22.

    Article  CAS  PubMed  Google Scholar 

  60. Matoso A, Chen YB, Rao V, Wang L, Cheng L, Epstein JI. Atypical renal cysts: a morphologic, immunohistochemical, and molecular study. Am J Surg Pathol. 2016;40(2):202–11.

    PubMed  Google Scholar 

  61. Suzigan S, Lopez-Beltran A, Montironi R, Drut R, Romero A, Hayashi T, et al. Multilocular cystic renal cell carcinoma: a report of 45 cases of a kidney tumor of low malignant potential. Am J Clin Pathol. 2006;125(2):217–22.

    Article  PubMed  Google Scholar 

  62. Williamson SR, MacLennan GT, Lopez-Beltran A, Montironi R, Tan PH, Martignoni G, et al. Cystic partially regressed clear cell renal cell carcinoma: a potential mimic of multilocular cystic renal cell carcinoma. Histopathology. 2013;63(6):767–79.

    Article  PubMed  Google Scholar 

  63. Williamson SR, Halat S, Eble JN, Grignon DJ, Lopez-Beltran A, Montironi R, et al. Multilocular cystic renal cell carcinoma: similarities and differences in immunoprofile compared with clear cell renal cell carcinoma. Am J Surg Pathol. 2012;36(10):1425–33.

    Article  PubMed  Google Scholar 

  64. Halat S, Eble JN, Grignon DJ, Lopez-Beltran A, Montironi R, Tan PH, et al. Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma. Mod Pathol. 2010;23(7):931–6.

    Article  PubMed  Google Scholar 

  65. Kenney PA, Vikram R, Prasad SR, Tamboli P, Matin SF, Wood CG, et al. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes. BJU Int. 2015;116(1):85–92.

    Article  PubMed  Google Scholar 

  66. Zhao M, He XL, Teng XD. Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects. Diagn Pathol. 2015;10:168.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  67. Tran T, Jones CL, Williamson SR, Eble JN, Grignon DJ, Zhang S, et al. Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma. Histopathology. 2016;68(6):850–7.

    Article  PubMed  Google Scholar 

  68. Ulamec M, Skenderi F, Zhou M, Kruslin B, Martinek P, Grossmann P, et al. Molecular genetic alterations in renal cell carcinomas with tubulocystic pattern: tubulocystic renal cell carcinoma, tubulocystic renal cell carcinoma with heterogenous component and familial leiomyomatosis-associated renal cell carcinoma. Clinicopathologic and molecular genetic analysis of 15 cases. Appl Immunohistochem Mol Morphol. 2016;24(7):521–30.

    Article  CAS  PubMed  Google Scholar 

  69. Zhou M, Yang XJ, Lopez JI, Shah RB, Hes O, Shen SS, et al. Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. Am J Surg Pathol. 2009;33(12):1840–9.

    Article  PubMed  Google Scholar 

  70. Foshat M, Eyzaguirre E. Acquired cystic disease-associated renal cell carcinoma: review of pathogenesis, morphology, ancillary tests, and clinical features. Arch Pathol Lab Med. 2017;141(4):600–6.

    Article  PubMed  Google Scholar 

  71. Kuroda N, Ohe C, Mikami S, Hes O, Michal M, Brunelli M, et al. Review of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspects. Histol Histopathol. 2011;26(9):1215–8.

    CAS  PubMed  Google Scholar 

  72. Grubb RL 3rd, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, et al. Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer. J Urol. 2007;177(6):2074–9; discussion 9–80.

    Article  CAS  PubMed  Google Scholar 

  73. Merino MJ, Torres-Cabala C, Pinto P, Linehan WM. The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Am J Surg Pathol. 2007;31(10):1578–85.

    Article  PubMed  Google Scholar 

  74. Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30(4):406–10.

    Article  CAS  PubMed  Google Scholar 

  75. Gill AJ, Hes O, Papathomas T, Sedivcova M, Tan PH, Agaimy A, et al. Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients. Am J Surg Pathol. 2014;38(12):1588–602.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Williamson SR, Eble JN, Amin MB, Gupta NS, Smith SC, Sholl LM, et al. Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma. Mod Pathol. 2015;28(1):80–94.

    Article  CAS  PubMed  Google Scholar 

  77. Al-Hussain T, Ali A, Akhtar M. Wilms tumor: an update. Adv Anat Pathol. 2014;21(3):166–73.

    Article  PubMed  Google Scholar 

  78. Brok J, Treger TD, Gooskens SL, van den Heuvel-Eibrink MM, Pritchard-Jones K. Biology and treatment of renal tumours in childhood. Eur J Cancer. 2016;68:179–95.

    Article  CAS  PubMed  Google Scholar 

  79. Cone EB, Dalton SS, Van Noord M, Tracy ET, Rice HE, Routh JC. Biomarkers for Wilms tumor: a systematic review. J Urol. 2016;196(5):1530–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Ooms AH, Gadd S, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, et al. Significance of TP53 mutation in Wilms tumors with diffuse anaplasia: a report from the children’s oncology group. Clin Cancer Res. 2016;22(22):5582–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Cochand-Priollet B, Molinie V, Bougaran J, Bouvier R, Dauge-Geffroy MC, Deslignieres S, et al. Renal chromophobe cell carcinoma and oncocytoma. A comparative morphologic, histochemical, and immunohistochemical study of 124 cases. Arch Pathol Lab Med. 1997;121(10):1081–6.

    CAS  PubMed  Google Scholar 

  82. Hes O, Michal M, Sima R, Vanecek T, Brunelli M, Martignoni G, et al. Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features. Virchows Arch. 2008;452(3):285–93.

    Article  PubMed  Google Scholar 

  83. Kryvenko ON, Jorda M, Argani P, Epstein JI. Diagnostic approach to eosinophilic renal neoplasms. Arch Pathol Lab Med. 2014;138(11):1531–41.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Kuroda N, Toi M, Hiroi M, Shuin T, Enzan H. Review of renal oncocytoma with focus on clinical and pathobiological aspects. Histol Histopathol. 2003;18(3):935–42.

    CAS  PubMed  Google Scholar 

  85. Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB, et al. Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol. 1997;21(8):871–83.

    Article  CAS  PubMed  Google Scholar 

  86. Bhatt JR, Richard PO, Kim NS, Finelli A, Manickavachagam K, Legere L, et al. Natural history of renal angiomyolipoma (AML): most patients with large AMLs >4cm can be offered active surveillance as an initial management strategy. Eur Urol. 2016;70(1):85–90.

    Article  PubMed  Google Scholar 

  87. Brimo F, Robinson B, Guo C, Zhou M, Latour M, Epstein JI. Renal epithelioid angiomyolipoma with atypia: a series of 40 cases with emphasis on clinicopathologic prognostic indicators of malignancy. Am J Surg Pathol. 2010;34(5):715–22.

    PubMed  Google Scholar 

  88. Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, et al. Update on the diagnosis and management of renal angiomyolipoma. J Urol. 2016;195(4 Pt 1):834–46.

    Article  PubMed  Google Scholar 

  89. Mehta V, Venkataraman G, Antic T, Rubinas TC, Le Poole IC, Picken MM. Renal angiomyolipoma, fat-poor variant–a clinicopathologic mimicker of malignancy. Virchows Arch. 2013;463(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  90. Bastide C, Rambeaud JJ, Bach AM, Russo P. Metanephric adenoma of the kidney: clinical and radiological study of nine cases. BJU Int. 2009;103(11):1544–8.

    Article  PubMed  Google Scholar 

  91. Kinney SN, Eble JN, Hes O, Williamson SR, Grignon DJ, Wang M, et al. Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. Mod Pathol. 2015;28(9):1236–48.

    Article  CAS  PubMed  Google Scholar 

  92. McNeil JC, Corbett ST, Kuruvilla S, Jones EA. Metanephric adenoma in a five-year-old boy presenting with chyluria: case report and review of literature. Urology. 2008;72(3):545–7.

    Article  PubMed  Google Scholar 

  93. Calio A, Eble JN, Grignon DJ, Delahunt B. Mixed epithelial and stromal tumor of the kidney: a clinicopathologic study of 53 cases. Am J Surg Pathol. 2016;40(11):1538–49.

    Article  PubMed  Google Scholar 

  94. Calio A, Eble JN, Grignon DJ, Delahunt B. Cystic nephroma in adults: a clinicopathologic study of 46 cases. Am J Surg Pathol. 2016;40(12):1591–600.

    Article  PubMed  Google Scholar 

  95. Li Y, Pawel BR, Hill DA, Epstein JI, Argani P. Pediatric cystic nephroma is morphologically, immunohistochemically, and genetically distinct from adult cystic nephroma. Am J Surg Pathol. 2017;41(4):472–81.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA

    Tiffany M. Graham, Todd M. Stevens & Jennifer B. Gordetsky

  2. University of Alabama at Birmingham, Department of Urology, Birmingham, AL, USA

    Jennifer B. Gordetsky

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  1. Tiffany M. Graham
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  2. Todd M. Stevens
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  1. The James Buchanan Brady Urological, Institute and Department of Urology, Johns Hopkins University School of Medic, Baltimore, MD, USA

    Michael A. Gorin

  2. The James Buchanan Brady Urological, Institute and Department of Urology, Johns Hopkins University School of Medic, Baltimore, MD, USA

    Mohamad E. Allaf

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Graham, T.M., Stevens, T.M., Gordetsky, J.B. (2019). Pathology of Renal Tumors. In: Gorin, M., Allaf, M. (eds) Diagnosis and Surgical Management of Renal Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-92309-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-92309-3_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92308-6

  • Online ISBN: 978-3-319-92309-3

  • eBook Packages: MedicineMedicine (R0)

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