Abstract
Liver resection for colorectal and neuroendocrine hepatic metastases has traditionally been associated with favorable results in well-selected patients. However, the role of hepatic resection and other liver-directed therapies for non-colorectal, non-neuroendocrine liver metastases has been less adequately described. In this chapter, we review the current literature on surgical and other locoregional treatment strategies for non-colorectal, non-neuroendocrine liver metastases, focusing on prognostic factors, survival outcomes, and selection criteria based on the specific histology of the primary tumor, including breast cancer, genitourinary tract cancer, non-colorectal gastrointestinal tract cancer, and melanoma.
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References
Malik HZ, Prasad KR, Halazun KJ, et al. Preoperative prognostic score for predicting survival after hepatic resection for colorectal liver metastases. Ann Surg. 2007;246:806–14.
Quan D, Gallinger S, Nhan C, et al. The role of liver resection for colorectal cancer metastases in an era of multimodality treatment: a systematic review. Surgery. 2012;151:860–70.
Simmonds PC, Primrose JN, Colquitt JL, et al. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer. 2006;94:982–99.
Mayo SC, de Jong MC, Pulitano C, et al. Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis. Ann Surg Oncol. 2010;17:3129–36.
Mayo SC, de Jong MC, Bloomston M, et al. Surgery versus intra-arterial therapy for neuroendocrine liver metastasis: a multicenter international analysis. Ann Surg Oncol. 2011;18:3657–65.
Groeschl RT, Nachmany I, Steel JL, et al. Hepatectomy for noncolorectal non-neuroendocrine metastatic cancer: a multi-institutional analysis. J Am Coll Surg. 2012;214:769–77.
Cordera F, Rea DJ, Rodriguez-Davalos M, et al. Hepatic resection for noncolorectal, nonneuroendocrine metastases. J Gastrointest Surg. 2005;9:1361–70.
Adam R, Chiche L, Aloia T, et al. Hepatic resection for noncolorectal nonendocrine liver metastases: analysis of 1,452 patients and development of a prognostic model. Ann Surg. 2006;244:524–35.
Abood G, Bowen M, Potkul R, et al. Hepatic resection for recurrent metastatic ovarian cancer. Am J Surg. 2008;195:370–3; discussion 373.
Bosquet JG, Merideth MA, Podratz KC, et al. Hepatic resection for metachronous metastases from ovarian carcinoma. HPB (Oxford). 2006;8:93–6.
Merideth MA, Cliby WA, Keeney GL, et al. Hepatic resection for metachronous metastases from ovarian carcinoma. Gynecol Oncol. 2003;89:16–21.
Elias D, Cavalcanti de Albuquerque A, Eggenspieler P, et al. Resection of liver metastases from a noncolorectal primary: indications and results based on 147 monocentric patients. J Am Coll Surg. 1998;187:487–93.
Ruys AT, Tanis PJ, Nagtegaal ID, et al. Surgical treatment of renal cell cancer liver metastases: a population-based study. Ann Surg Oncol. 2011;18:1932–8.
Goulet RJ Jr, Hardacre JM, Einhorn LH, et al. Hepatic resection for disseminated germ cell carcinoma. Ann Surg. 1990;212:290–3; discussion 293–4.
Roh HJ, Kim DY, Joo WD, et al. Hepatic resection as part of secondary cytoreductive surgery for recurrent ovarian cancer involving the liver. Arch Gynecol Obstet. 2011;284:1223–9.
Alves A, Adam R, Majno P, et al. Hepatic resection for metastatic renal tumors: is it worthwhile? Ann Surg Oncol. 2003;10:705–10.
Weitz J, Blumgart LH, Fong Y, et al. Partial hepatectomy for metastases from noncolorectal, nonneuroendocrine carcinoma. Ann Surg. 2005;241:269–76.
Stief CG, Jahne J, Hagemann JH, et al. Surgery for metachronous solitary liver metastases of renal cell carcinoma. J Urol. 1997;158:375–7.
Staehler MD, Kruse J, Haseke N, et al. Liver resection for metastatic disease prolongs survival in renal cell carcinoma: 12-year results from a retrospective comparative analysis. World J Urol. 2010;28:543–7.
Langan RC, Ripley RT, Davis JL, et al. Liver directed therapy for renal cell carcinoma. J Cancer. 2012;3:184–90.
You YN, Leibovitch BC, Que FG. Hepatic metastasectomy for testicular germ cell tumors: is it worth it? J Gastrointest Surg. 2009;13:595–601.
Motzer RJ, Mazumdar M, Bacik J, et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999;17:2530–40.
Temkin SM, Fleming G. Current treatment of metastatic endometrial cancer. Cancer Control. 2009;16:38–45.
Adam R, Aloia T, Krissat J, et al. Is liver resection justified for patients with hepatic metastases from breast cancer? Ann Surg. 2006;244:897–907; discussion 907–8.
Pocard M, Pouillart P, Asselain B, et al. Hepatic resection in metastatic breast cancer: results and prognostic factors. Eur J Surg Oncol. 2000;26:155–9.
Abbott DE, Brouquet A, Mittendorf EA, et al. Resection of liver metastases from breast cancer: estrogen receptor status and response to chemotherapy before metastasectomy define outcome. Surgery. 2012;151:710–6.
Thelen A, Benckert C, Jonas S, et al. Liver resection for metastases from breast cancer. J Surg Oncol. 2008;97:25–9.
Fitzgerald TL, Brinkley J, Banks S, et al. The benefits of liver resection for non-colorectal, non-neuroendocrine liver metastases: a systematic review. Langenbecks Arch Surg. 2014;399:989–1000.
Mariani P, Servois V, De Rycke Y, et al. Liver metastases from breast cancer: surgical resection or not? A case-matched control study in highly selected patients. Eur J Surg Oncol. 2013;39:1377–83.
Spolverato G, Vitale A, Bagante F, et al. Liver resection for breast cancer liver metastases: a cost-utility analysis. Ann Surg. 2017;265:792–9.
Sadot E, Lee SY, Sofocleous CT, et al. Hepatic resection or ablation for isolated breast cancer liver metastasis: a case-control study with comparison to medically treated patients. Ann Surg. 2016;264:147–54.
Bresadola V, Rossetto A, Adani GL, et al. Liver resection for noncolorectal and nonneuroendocrine metastases: results of a study on 56 patients at a single institution. Tumori. 2011;97:316–22.
de Jong MC, Tsai S, Cameron JL, et al. Safety and efficacy of curative intent surgery for peri-ampullary liver metastasis. J Surg Oncol. 2010;102:256–63.
Polee MB, Hop WC, Kok TC, et al. Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy. Br J Cancer. 2003;89:2045–50.
Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817–25.
Slotta JE, Schuld J, Distler S, et al. Hepatic resection of non-colorectal and non-neuroendocrine liver metastases—survival benefit for patients with non-gastrointestinal primary cancers—a case-controlled study. Int J Surg. 2014;12:163–8.
Shima Y, Horimi T, Ishikawa T, et al. Aggressive surgery for liver metastases from gastrointestinal stromal tumors. J Hepatobiliary Pancreat Surg. 2003;10:77–80.
DeMatteo RP, Shah A, Fong Y, et al. Results of hepatic resection for sarcoma metastatic to liver. Ann Surg. 2001;234:540–7; discussion 547–8.
Nunobe S, Sano T, Shimada K, et al. Surgery including liver resection for metastatic gastrointestinal stromal tumors or gastrointestinal leiomyosarcomas. Jpn J Clin Oncol. 2005;35:338–41.
Xia L, Zhang MM, Ji L, et al. Resection combined with imatinib therapy for liver metastases of gastrointestinal stromal tumors. Surg Today. 2010;40:936–42.
Pawlik TM, Vauthey JN, Abdalla EK, et al. Results of a single-center experience with resection and ablation for sarcoma metastatic to the liver. Arch Surg. 2006;141:537–43; discussion 543–4.
Pawlik TM, Zorzi D, Abdalla EK, et al. Hepatic resection for metastatic melanoma: distinct patterns of recurrence and prognosis for ocular versus cutaneous disease. Ann Surg Oncol. 2006;13:712–20.
Rivoire M, Kodjikian L, Baldo S, et al. Treatment of liver metastases from uveal melanoma. Ann Surg Oncol. 2005;12:422–8.
Mariani P, Piperno-Neumann S, Servois V, et al. Surgical management of liver metastases from uveal melanoma: 16 years’ experience at the Institut Curie. Eur J Surg Oncol. 2009;35:1192–7.
Earle SA, Perez EA, Gutierrez JC, et al. Hepatectomy enables prolonged survival in select patients with isolated noncolorectal liver metastasis. J Am Coll Surg. 2006;203:436–46.
Berney T, Mentha G, Roth AD, et al. Results of surgical resection of liver metastases from non-colorectal primaries. Br J Surg. 1998;85:1423–7.
Duan XF, Dong NN, Zhang T, et al. Comparison of surgical outcomes in patients with colorectal liver metastases versus non-colorectal liver metastases: a Chinese experience. Hepatol Res. 2012;42:296–303.
Lindell G, Ohlsson B, Saarela A, et al. Liver resection of noncolorectal secondaries. J Surg Oncol. 1998;69:66–70.
Treska V, Liska V, Skalicky T, et al. Non-colorectal liver metastases: surgical treatment options. Hepatogastroenterology. 2012;59:245–8.
Takada Y, Otsuka M, Seino K, et al. Hepatic resection for metastatic tumors from noncolorectal carcinoma. Hepatogastroenterology. 2001;48:83–6.
Lendoire J, Moro M, Andriani O, et al. Liver resection for non-colorectal, non-neuroendocrine metastases: analysis of a multicenter study from Argentina. HPB (Oxford). 2007;9:435–9.
Harrison LE, Brennan MF, Newman E, et al. Hepatic resection for noncolorectal, nonneuroendocrine metastases: a fifteen-year experience with ninety-six patients. Surgery. 1997;121:625–32.
Yedibela S, Gohl J, Graz V, et al. Changes in indication and results after resection of hepatic metastases from noncolorectal primary tumors: a single-institutional review. Ann Surg Oncol. 2005;12:778–85.
van Ruth S, Mutsaerts E, Zoetmulder FA, et al. Metastasectomy for liver metastases of non-colorectal primaries. Eur J Surg Oncol. 2001;27:662–7.
Goering JD, Mahvi DM, Niederhuber JE, et al. Cryoablation and liver resection for noncolorectal liver metastases. Am J Surg. 2002;183:384–9.
Verhoef C, Kuiken BW, IJzermans JN, et al. Partial hepatic resection for liver metastases of non-colorectal origin, is it justified? Hepatogastroenterology. 2007;54:1517–21.
Ercolani G, Vetrone G, Grazi GL, et al. The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE). Analysis of 134 resected patients. Minerva Chir. 2009;64:551–8.
Karavias DD, Tepetes K, Karatzas T, et al. Liver resection for metastatic non-colorectal non-neuroendocrine hepatic neoplasms. Eur J Surg Oncol. 2002;28:135–9.
Takemura N, Saiura A, Koga R, et al. Long-term results of hepatic resection for non-colorectal, non-neuroendocrine liver metastasis. Hepatogastroenterology. 2013;60:1705–12.
O’Rourke TR, Tekkis P, Yeung S, et al. Long-term results of liver resection for non-colorectal, non-neuroendocrine metastases. Ann Surg Oncol. 2008;15:207–18.
Marudanayagam R, Sandhu B, Perera MT, et al. Hepatic resection for non-colorectal, non-neuroendocrine, non-sarcoma metastasis: a single-centre experience. HPB (Oxford). 2011;13:286–92.
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Fong, Z.V., Poultsides, G.A., Qadan, M. (2018). Patient Selection and Guidelines for Resection and Liver-Directed Therapies: Non-colorectal, Non-neuroendocrine Liver Metastases. In: Cardona, K., Maithel, S. (eds) Primary and Metastatic Liver Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-91977-5_23
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DOI: https://doi.org/10.1007/978-3-319-91977-5_23
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