Skip to main content
SpringerLink
Log in

Ablative Techniques for Colorectal Cancer Liver Metastases

  • Chapter
  • First Online:
Primary and Metastatic Liver Tumors

  • 606 Accesses

Abstract

The use of extreme temperatures to treat tumors dates back over a century [1]. However, in parallel with the dramatic evolution of liver surgery, the last three decades have seen an accelerated expansion of techniques and indications for liver tumor ablation, and they are currently considered complementary strategies in the treatment of primary and secondary liver malignancies. Moreover, ablation has become an accepted alternative to hepatic resection in a select group of patients with both primary and metastatic liver neoplasms. Indications for ablative therapies include patients considered unfit for surgery due to either location of the lesion or poor health, those with smaller lesions, or those in whom a small amount of remnant liver parenchyma precludes resection [2, 3]. These techniques have also been advocated as a bridge to transplantation in patients facing a long waiting list for a liver allograft [4, 5].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Beer E. Landmark article May 28, 1910: removal of neoplasms of the urinary bladder. By Edwin Beer. JAMA. 1983;250(10):1324–5.

    Article  CAS  Google Scholar 

  2. Rocha FG, D’Angelica M. Treatment of liver colorectal metastases: role of laparoscopy, radiofrequency ablation, and microwave coagulation. J Surg Oncol. 2010;102(8):968–74.

    Article  Google Scholar 

  3. Livraghi T. Radiofrequency ablation of hepatocellular carcinoma. Surg Oncol Clin N Am. 2011;20(2):281–99, viii.

    Article  Google Scholar 

  4. DuBay DA, Sandroussi C, Kachura JR, Ho CS, Beecroft JR, Vollmer CM, et al. Radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation. HPB (Oxford). 2011;13(1):24–32.

    Article  Google Scholar 

  5. Panaro F, Piardi T, Audet M, Gheza F, Woehl-Jaegle ML, Portolani N, et al. Laparoscopic ultrasound-guided radiofrequency ablation as a bridge to liver transplantation for hepatocellular carcinoma: preliminary results. Transplant Proc. 2010;42(4):1179–81.

    Article  CAS  Google Scholar 

  6. Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver. 2010;4(Suppl 1):S99–S104.

    Article  Google Scholar 

  7. Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST. Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology. 2010;255(2):426–33.

    Article  Google Scholar 

  8. Topal B, Aerts R, Penninckx F. Laparoscopic radiofrequency ablation of unresectable liver malignancies: feasibility and clinical outcome. Surg Laparosc Endosc Percutan Tech. 2003;13(1):11–5.

    Article  Google Scholar 

  9. Asahina Y, Nakanishi H, Izumi N. Laparoscopic radiofrequency ablation for hepatocellular carcinoma. Dig Endosc. 2009;21(2):67–72.

    Article  Google Scholar 

  10. Vogl TJ, Mack MG, Straub R, Roggan A, Felix R. Magnetic resonance imaging--guided abdominal interventional radiology: laser-induced thermotherapy of liver metastases. Endoscopy. 1997;29(6):577–83.

    Article  CAS  Google Scholar 

  11. Boaz TL, Lewin JS, Chung YC, Duerk JL, Clampitt ME, Haaga JR. MR monitoring of MR-guided radiofrequency thermal ablation of normal liver in an animal model. J Magn Reson Imaging. 1998;8(1):64–9.

    Article  CAS  Google Scholar 

  12. Lewin JS, Connell CF, Duerk JL, Chung YC, Clampitt ME, Spisak J, et al. Interactive MRI-guided radiofrequency interstitial thermal ablation of abdominal tumors: clinical trial for evaluation of safety and feasibility. J Magn Reson Imaging. 1998;8(1):40–7.

    Article  CAS  Google Scholar 

  13. Aschoff AJ, Rafie N, Jesberger JA, Duerk JL, Lewin JS. Thermal lesion conspicuity following interstitial radiofrequency thermal tumor ablation in humans: a comparison of STIR, turbo spin-echo T2-weighted, and contrast-enhanced T1-weighted MR images at 0.2 T. J Magn Reson Imaging. 2000;12(4):584–9.

    Article  CAS  Google Scholar 

  14. Breen MS, Lazebnik RS, Fitzmaurice M, Nour SG, Lewin JS, Wilson DL. Radiofrequency thermal ablation: correlation of hyperacute MR lesion images with tissue response. J Magn Reson Imaging. 2004;20(3):475–86.

    Article  Google Scholar 

  15. Breen MS, Lazebnik RS, Nour SG, Lewin JS, Wilson DL. Three-dimensional comparison of interventional MR radiofrequency ablation images with tissue response. Comput Aided Surg. 2004;9(5):185–91.

    PubMed  Google Scholar 

  16. Mahnken AH, Buecker A, Spuentrup E, Krombach GA, Henzler D, Gunther RW, et al. MR-guided radiofrequency ablation of hepatic malignancies at 1.5 T: initial results. J Magn Reson Imaging. 2004;19(3):342–8.

    Article  Google Scholar 

  17. Cernicanu A, Lepetit-Coiffe M, Viallon M, Terraz S, Becker CD. New horizons in MR-controlled and monitored radiofrequency ablation of liver tumours. Cancer Imaging. 2007;7:160–6.

    Article  Google Scholar 

  18. Boss A, Rempp H, Martirosian P, Clasen S, Schraml C, Stenzl A, et al. Wide-bore 1.5 Tesla MR imagers for guidance and monitoring of radiofrequency ablation of renal cell carcinoma: initial experience on feasibility. Eur Radiol. 2008;18(7):1449–55.

    Article  Google Scholar 

  19. Chopra SS, Schmidt SC, Wiltberger G, Denecke T, Streitparth F, Seebauer C, et al. Laparoscopic radiofrequency ablation of liver tumors: comparison of MR guidance versus conventional laparoscopic ultrasound for needle positioning in a phantom model. Minim Invasive Ther Allied Technol. 2011;20(4):212–7.

    Article  Google Scholar 

  20. Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67(3):177–93.

    Article  Google Scholar 

  21. D’Angelica MI, Correa-Gallego C, Paty PB, Cercek A, Gewirtz AN, Chou JF, et al. Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes. Ann Surg. 2015;261(2):353–60.

    Article  Google Scholar 

  22. D’Angelica M, Brennan MF, Fortner JG, Cohen AM, Blumgart LH, Fong Y. Ninety-six five-year survivors after liver resection for metastatic colorectal cancer. J Am Coll Surg. 1997;185(6):554–9.

    Article  Google Scholar 

  23. Tomlinson JS, Jarnagin WR, DeMatteo RP, Fong Y, Kornprat P, Gonen M, et al. Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol. 2007;25(29):4575–80.

    Article  Google Scholar 

  24. Beer E. Removal of neoplasms of the urinary bladder; a new method, employing high-frequency (oudin) currents through a catheterizing cystoscope. Am J Med. 1952;13(5):542–3.

    Article  CAS  Google Scholar 

  25. Clark WL. Indications for the use of electrosurgical methods. N Engl J Med. 1931;204(3):110–5.

    Article  Google Scholar 

  26. Goldwyn RM. Bovie: the man and the machine. Ann Plast Surg. 1979;2(2):135–53.

    Article  CAS  Google Scholar 

  27. McGahan JP, Browning PD, Brock JM, Tesluk H. Hepatic ablation using radiofrequency electrocautery. Investig Radiol. 1990;25(3):267–70.

    Article  CAS  Google Scholar 

  28. McGahan JP, Gu WZ, Brock JM, Tesluk H, Jones CD. Hepatic ablation using bipolar radiofrequency electrocautery. Acad Radiol. 1996;3(5):418–22.

    Article  CAS  Google Scholar 

  29. Hong K, Georgiades C. Radiofrequency ablation: mechanism of action and devices. J Vasc Interv Radiol. 2010;21(8 Suppl):S179–86.

    Article  Google Scholar 

  30. Lu DS, Raman SS, Limanond P, Aziz D, Economou J, Busuttil R, et al. Influence of large peritumoral vessels on outcome of radiofrequency ablation of liver tumors. J Vasc Interv Radiol. 2003;14(10):1267–74.

    Article  Google Scholar 

  31. Lubner MG, Brace CL, Hinshaw JL, Lee FT Jr. Microwave tumor ablation: mechanism of action, clinical results, and devices. J Vasc Interv Radiol. 2010;21(8 Suppl):S192–203.

    Article  Google Scholar 

  32. Yu NC, Raman SS, Kim YJ, Lassman C, Chang X, Lu DS. Microwave liver ablation: influence of hepatic vein size on heat-sink effect in a porcine model. J Vasc Interv Radiol. 2008;19(7):1087–92.

    Article  Google Scholar 

  33. Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW, Lee FT Jr. Microwave ablation with multiple simultaneously powered small-gauge triaxial antennas: results from an in vivo swine liver model. Radiology. 2007;244(1):151–6.

    Article  Google Scholar 

  34. Leung U, Kuk D, D’Angelica MI, Kingham TP, Allen PJ, DeMatteo RP, et al. Long-term outcomes following microwave ablation for liver malignancies. Br J Surg. 2015;102(1):85–91.

    Article  CAS  Google Scholar 

  35. van Tilborg AA, Scheffer HJ, de Jong MC, Vroomen LG, Nielsen K, van Kuijk C, et al. MWA versus RFA for perivascular and peribiliary CRLM: a retrospective patient- and lesion-based analysis of two historical cohorts. Cardiovasc Intervent Radiol. 2016;39(10):1438–46.

    Article  Google Scholar 

  36. Correa-Gallego C, Fong Y, Gonen M, D’Angelica MI, Allen PJ, DeMatteo RP, et al. A retrospective comparison of microwave ablation vs. radiofrequency ablation for colorectal cancer hepatic metastases. Ann Surg Oncol. 2014;21(13):4278–83.

    Article  Google Scholar 

  37. Erinjeri JP, Clark TW. Cryoablation: mechanism of action and devices. J Vasc Interv Radiol. 2010;21(8 Suppl):S187–91.

    Article  Google Scholar 

  38. Pearson AS, Izzo F, Fleming RY, Ellis LM, Delrio P, Roh MS, et al. Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. Am J Surg. 1999;178(6):592–9.

    Article  CAS  Google Scholar 

  39. Adam R, Akpinar E, Johann M, Kunstlinger F, Majno P, Bismuth H. Place of cryosurgery in the treatment of malignant liver tumors. Ann Surg. 1997;225(1):39–8; discussion 48–50.

    Article  CAS  Google Scholar 

  40. Kingham TP, Tanoue M, Eaton A, Rocha FG, Do R, Allen P, et al. Patterns of recurrence after ablation of colorectal cancer liver metastases. Ann Surg Oncol. 2012;19(3):834–41.

    Article  Google Scholar 

  41. Weng M, Zhang Y, Zhou D, Yang Y, Tang Z, Zhao M, et al. Radiofrequency ablation versus resection for colorectal cancer liver metastases: a meta-analysis. PLoS One. 2012;7(9):e45493.

    Article  CAS  Google Scholar 

  42. Gillams A, Goldberg N, Ahmed M, Bale R, Breen D, Callstrom M, et al. Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, the interventional oncology sans frontieres meeting 2013. Eur Radiol. 2015;25(12):3438–54.

    Article  Google Scholar 

  43. Gillams AR, Lees WR. Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation. Eur Radiol. 2009;19(5):1206–13.

    Article  CAS  Google Scholar 

  44. Folprecht G, Gruenberger T, Bechstein WO, Raab HR, Lordick F, Hartmann JT, et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010;11(1):38–47.

    Article  CAS  Google Scholar 

  45. Pozzo C, Basso M, Cassano A, Quirino M, Schinzari G, Trigila N, et al. Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients. Ann Oncol. 2004;15(6):933–9.

    Article  CAS  Google Scholar 

  46. Imai K, Allard MA, Castro Benitez C, Vibert E, Sa Cunha A, Cherqui D, et al. Long-term outcomes of radiofrequency ablation combined with hepatectomy compared with hepatectomy alone for colorectal liver metastases. Br J Surg. 2017;104(5):570–9.

    Article  CAS  Google Scholar 

  47. Ruers T, Punt C, Van Coevorden F, Pierie JP, Borel-Rinkes I, Ledermann JA, et al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol. 2012;23(10):2619–26.

    Article  CAS  Google Scholar 

  48. Ruers T, Van Coevorden F, Punt CJ, Pierie JE, Borel-Rinkes I, Ledermann JA, et al. Local treatment of unresectable colorectal liver metastases: results of a randomized phase II trial. J Natl Cancer Inst. 2017;109(9).

    Google Scholar 

  49. Kingham TP, Karkar AM, D’Angelica MI, Allen PJ, Dematteo RP, Getrajdman GI, et al. Ablation of perivascular hepatic malignant tumors with irreversible electroporation. J Am Coll Surg. 2012;215(3):379–87.

    Article  Google Scholar 

  50. Langan RC, Goldman DA, D'Angelica MI, DeMatteo RP, Allen PJ, Balachandran VP, et al. Recurrence patterns following irreversible electroporation for hepatic malignancies. J Surg Oncol. 2017;115(6):704–10.

    Article  CAS  Google Scholar 

  51. Scheffer HJ, Vroomen LG, Nielsen K, van Tilborg AA, Comans EF, van Kuijk C, et al. Colorectal liver metastatic disease: efficacy of irreversible electroporation—a single-arm phase II clinical trial (COLDFIRE-2 trial). BMC Cancer. 2015;15:772.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Camilo Correa-Gallego

  2. Division of Hepatopancreatobiliary Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    T. Peter Kingham

Authors
  1. Camilo Correa-Gallego
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Peter Kingham
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Camilo Correa-Gallego .

Editor information

Editors and Affiliations

  1. Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital Midtown, Atlanta, GA, USA

    Kenneth Cardona

  2. Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital, Atlanta, GA, USA

    Shishir K. Maithel

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Correa-Gallego, C., Kingham, T.P. (2018). Ablative Techniques for Colorectal Cancer Liver Metastases. In: Cardona, K., Maithel, S. (eds) Primary and Metastatic Liver Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-91977-5_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-91977-5_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-91976-8

  • Online ISBN: 978-3-319-91977-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation