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Current and Emerging Medical Therapies for Advanced Disease in Intrahepatic Cholangiocarcinoma

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Primary and Metastatic Liver Tumors

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Abstract

Biliary tract cancers are rare cancers with traditionally dismal clinical outcomes. Systemic chemotherapy remains the mainstay of treatment for patients with advanced disease. Combination therapy with cisplatin and gemcitabine is the current standard of care. Recent advancements in genomic profiling and next-generation sequencing technologies have led to a growing understanding of the true heterogeneity within this disease. Large mutational profiling studies have identified key genomic differences among intrahepatic and extrahepatic cholangiocarcinoma and gallbladder carcinoma. Understanding these genomic alterations and identifying targetable mutations will be critical to developing effective biomarker and targeted therapy options. In this chapter, we will review current and emerging systemic treatment options for cholangiocarcinoma.

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Authors and Affiliations

  1. Sidney Kimmel Cancer Center, Thomas Jefferson University Hospitalh, Philadelphia, PA, USA

    Aileen Deng

  2. Rosenfeld Cancer Center at Abington Jefferson Health, Abington, PA, USA

    Steven Cohen

  3. Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA, USA

    Steven Cohen

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  1. Aileen Deng
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  2. Steven Cohen
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Correspondence to Steven Cohen .

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Editors and Affiliations

  1. Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital Midtown, Atlanta, GA, USA

    Kenneth Cardona

  2. Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital, Atlanta, GA, USA

    Shishir K. Maithel

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Deng, A., Cohen, S. (2018). Current and Emerging Medical Therapies for Advanced Disease in Intrahepatic Cholangiocarcinoma. In: Cardona, K., Maithel, S. (eds) Primary and Metastatic Liver Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-91977-5_11

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