Abstract
To compare parameters in different mammals we make use of the so-called allometric equation: PA = PA0 Me, with PA the parameter of interest, PA0 a reference value, M body mass, and e the exponent. The R p C-time of aortic pressure decay in diastole, and heart period, T period , both scale as M1/4, their ratio thus being independent of body mass and thus similar in mammals. Volume parameters such a heart size and Stroke Volume, SV, are proportional to body mass. Since CO equals HR times SV, CO is proportional to M3/4. Basal metabolism is proportional to CO, and thus also proportional to M3/4. The coupling parameters (Chap. 14 and 31) are independent of body mass. The ratio of peripheral resistance and aortic characteristic impedance is also independent of animal size, implying that normalized aortic input impedance is similar in mammals. These mass-independent relations imply that wave shapes of pressure and flow are similar, pressures equal, but CO=CO0M3/4 and Basal Metabolism, BMr=BMr0M3/4, depend on body mass. The quantitative similarity of pressures in mammals suggest that even borderline hypertension is abnormal.
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Westerhof, N., Stergiopulos, N., Noble, M.I.M., Westerhof, B.E. (2019). Comparative Physiology. In: Snapshots of Hemodynamics. Springer, Cham. https://doi.org/10.1007/978-3-319-91932-4_32
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