Abstract
The ventricular pressure-volume relation, is an important presentation of global cardiac pump function. With every heart beat a full pressure-volume loop is described. When ventricular filling is changed, another loop starting from a different End-Diastolic Pressure and End-Diastolic Volume is described. The left top corners of the pressure-volume loops, i.e., the End-Systolic points, when interconnected, and approximated with a straight line give the End-Systolic Pressure-Volume relation, ESPVR, with its slope called E es. The Ees is independent of the (arterial) load and determined by systolic muscle properties (contractility) and wall mass. The Diastolic Pressure-Volume Relation is found by connecting the End-Diastolic Pressure and Volume points. The relation depends on diastolic muscle properties and wall thickness; the relation has considerable curvature but can be fitted with an exponential relation and its slope at end-diastole is End-Diastolic Elastance, E d. Filling changes in vivo can be obtained by partial vena cava occlusions. So-called ‘single beat’ methods have been developed to derive Ees and Ed.
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Westerhof, N., Stergiopulos, N., Noble, M.I.M., Westerhof, B.E. (2019). The Pressure-Volume Relation. In: Snapshots of Hemodynamics. Springer, Cham. https://doi.org/10.1007/978-3-319-91932-4_14
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DOI: https://doi.org/10.1007/978-3-319-91932-4_14
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