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Esophageal Adenocarcinoma: Pathogenesis and Epidemiology

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Book cover Esophageal Cancer

Abstract

Over the past 40 years, the incidence of esophageal adenocarcinoma (EAC) has increased more than sixfold in Western countries. The increase incidence of EAC has been attributed to the rising prevalence of obesity and gastroesophageal reflux disease (GERD). GERD affects an estimated 20% of the population in the US, and its prevalence is increasing worldwide. About 10–15% of patients with GERD will develop Barrett’s esophagus (BE). This metaplastic lesion due to the chronic injury produced by repeated reflux episodes involves genetic mutations that can lead to a malignant transformation. The development of EAC is characterized by the progression from BE metaplasia to dysplasia, and ultimately invasive carcinoma.

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Author information

Authors and Affiliations

  1. Department of Surgery, Hospital Alemán of Buenos Aires, University of Buenos Aires, Buenos Aires, Argentina

    Francisco Schlottmann

  2. Department of Medicine and Surgery, University of North Carolina, Chapel Hill, NC, USA

    Marco G. Patti

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  1. Francisco Schlottmann
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  2. Marco G. Patti
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Editors and Affiliations

  1. Hospital Alemán of Buenos Aires, University of Buenos Aires, Buenos Aires, Argentina

    Francisco Schlottmann

  2. Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Daniela Molena

  3. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    Marco G. Patti

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Schlottmann, F., Patti, M.G. (2018). Esophageal Adenocarcinoma: Pathogenesis and Epidemiology. In: Schlottmann, F., Molena, D., Patti, M. (eds) Esophageal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-91830-3_3

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  • DOI: https://doi.org/10.1007/978-3-319-91830-3_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-91829-7

  • Online ISBN: 978-3-319-91830-3

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