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Humoral Primary Immunodeficiencies pp 315–323Cite as

Malignancy in Predominantly Antibody Deficiencies (PAD)

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Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

Multiple case series and registry surveys address the incidence of malignancies in PID and lymphomas are reported frequently. Due to the rarity of PID, the results of many of the studies rely on relatively few patient numbers and might underlie a publication bias. A large registry study from the US reports that the incidence of the most common cancers in the general population (breast, colorectal, lung, prostate cancer) is not increased in PID patients, whereas the incidence of lymphoma, skin and thyroid cancer is significantly increased compared to the general population. While there is good evidence that patients with common variable immunodeficiency have an increased risk for B cell neoplasms and gastric adenocarcinoma, the data are less clear for other predominantly andibody deficiencies (PAD).

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Authors and Affiliations

  1. Center for Chronic Immunodeficiency (CCI), Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Claudia Wehr

  2. Department of Medicine I/Hematology, Oncology and Stem Cell Transplantation, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Claudia Wehr

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  1. Claudia Wehr
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Correspondence to Claudia Wehr .

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Editors and Affiliations

  1. Careggi Hospital, Department of Clinical and Experimental Medicine, University of Florence, Firenze, Italy

    Mario Milco D'Elios

  2. University Medical Centre Freiburg, Department of Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency, Freiburg, Germany

    Marta Rizzi

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Wehr, C. (2019). Malignancy in Predominantly Antibody Deficiencies (PAD). In: D'Elios, M., Rizzi, M. (eds) Humoral Primary Immunodeficiencies. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-91785-6_23

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  • DOI: https://doi.org/10.1007/978-3-319-91785-6_23

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