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Humoral Primary Immunodeficiencies pp 227–234Cite as

Good’s Syndrome (GS): Thymoma with Immunodeficiency

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Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

The association in adults of thymoma with hypogammaglobulinemia, low B-cell counts, and a variable degree of cellular immunodeficiency (low CD4 and NK cells) was first described by R.A. Good as a rare form of acquired combined immunodeficiency. Besides an increased susceptibility to respiratory infections with encapsulated bacteria, many patients suffer from chronic diarrhea, opportunistic infections (e.g., CMV, candida, tuberculosis, Pneumocystis), pure red cell aplasia (PRCA), and various autoimmune diseases notably myasthenia gravis (MG).

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Author information

Authors and Affiliations

  1. Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany

    Hans-Hartmut Peter

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  1. Hans-Hartmut Peter
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Correspondence to Hans-Hartmut Peter .

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Editors and Affiliations

  1. Careggi Hospital, Department of Clinical and Experimental Medicine, University of Florence, Firenze, Italy

    Mario Milco D'Elios

  2. University Medical Centre Freiburg, Department of Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency, Freiburg, Germany

    Marta Rizzi

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Peter, HH. (2019). Good’s Syndrome (GS): Thymoma with Immunodeficiency. In: D'Elios, M., Rizzi, M. (eds) Humoral Primary Immunodeficiencies. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-91785-6_18

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  • DOI: https://doi.org/10.1007/978-3-319-91785-6_18

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  • Online ISBN: 978-3-319-91785-6

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