Abstract
New daily persistent headache (NDPH) is a unique form of chronic daily headache. The distinguishing feature of NDPH is a headache that starts abruptly, and patients can often recall the exact day of headache onset. Clinically, NPDH lacks characteristic features and may resemble migraine or tension-type headache. Diagnosis relies on first eliminating secondary mimics. Several different classes of medications have been used for treatment of NDPH with varying results. In clinical practice, treatment is often chosen based on the headache phenotype. However, most therapies are ineffective or minimally effective thereby making NDPH one of the most refractory types of headache to treat.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Vanast W. New daily-persistent headaches: definition of a benign syndrome. Headache. 1986;26:318.
Headache Classification Committee of the International Headache Society. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.
Castillo J, Munoz P, Guitera V, Pascual J. Kaplan Award 1998. Epidemiology of chronic daily headache in the general population. Headache. 1999;39(3):190–6.
Bigal ME, Sheftell FD, Rapoport AM, Lipton RB, Tepper SJ. Chronic daily headache in a tertiary care population: correlation between the International Headache Society diagnostic criteria and proposed revisions of criteria for chronic daily headache. Cephalalgia. 2002;22(6):432–8.
Grande RB, Aaseth K, Lundqvist C, Russell MB. Prevalence of new daily persistent headache in the general population. The Akershus study of chronic headache. Cephalalgia. 2009;29(11):1149–55.
Koenig MA, Gladstein J, McCarter RJ, Hershey AD, Wasiewski W. Pediatric Committee of the American Headache Society. Chronic daily headache in children and adolescents presenting to tertiary headache clinics. Headache. 2002;42(6):491–500.
Bigal ME, Lipton RB, Tepper SJ, Rapoport AM, Sheftell FD. Primary chronic daily headache and its subtypes in adolescents and adults. Neurology. 2004;63(5):843–7.
Li D, Rozen TD. The clinical characteristics of new daily persistent headache. Cephalalgia. 2002;22(1):66–9.
Evans RW. New daily persistent headache. Headache. 2012;52(Suppl 1):40–4.
Robbins MS, Grosberg BM, Napchan U, Crystal SC, Lipton RB. Clinical and prognostic subforms of new daily-persistent headache. Neurology. 2010;74(17):1358–64.
Rozen TD. New daily persistent headache: a lack of an association with white matter abnormalities on neuroimaging. Cephalalgia. 2016;36(10):987–92.
Siberstein SD, Lipton RB, Solomon S, Mathew NT. Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache. 1994;34(1):1–7.
Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders: 2nd edition. Cephalalgia. 2004;24(Suppl 1):9–160.
Kung E, Tepper SJ, Rapoport AM, Sheftell FD, Bigal ME. New daily persistent headache in the paediatric population. Cephalalgia. 2009;29(1):17–22.
Robbins MS, Evans RW. The heterogeneity of new daily persistent headache. Headache. 2012;52(10):1579–89.
Young WB. New daily persistent headache: controversy in the diagnostic criteria. Curr Pain Headache Rep. 2011;15(1):47–50.
Grengs LR, Mack KJ. New daily persistent headache is most likely to begin at the start of school. J Child Neurol. 2016;31(7):864–8.
Uniyal R, Paliwal VK, Tripathi A. Psychiatric comorbidity in new daily persistent headache: a cross-sectional study. Eur J Pain. 2017;21:1031.
Robbins MS. New daily-persistent headache and anxiety. Cephalalgia. 2011;31(7):875–6.
Goadsby PJ. New daily persistent headache: a syndrome, not a discrete disorder. Headache. 2011;51(4):650–3.
Rozen TD. Triggering events and new daily persistent headache: age and gender differences and insights on pathogenesis-a clinic-based study. Headache. 2016;56(1):164–73.
Rozen T, Swidan SZ. Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. Headache. 2007;47(7):1050–5.
Rozen TD. New daily persistent headache: an update. Curr Pain Headache Rep. 2014;18(7):431.
Durham PL. Calcitonin gene-related peptide (CGRP) and migraine. Headache. 2006;46(Suppl 1):S3–8.
Rozen T, Roth J, Denenberg N. Joint hypermobility as a predisposing factor for the development of new daily persistent headache. Headache. 2005;45:828–9.
Piovesan EJ, Kowacs PA, Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Curr Pain Headache Rep. 2003;7(5):377–83.
Bigal ME, Lipton RB. Clinical course in migraine: conceptualizing migraine transformation. Neurology. 2008;71(11):848–55.
Mack KJ. New daily persistent headache in children and adults. Curr Pain Headache Rep. 2009;13(1):47–51.
Southerland AM, Login IS. Rigorously defined hemicrania continua presenting bilaterally. Cephalalgia. 2011;31(14):1490–2.
Schievink WI. Spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension. JAMA. 2006;295(19):2286–96.
Cumurciuc R, Crassard I, Sarov M, Valade D, Bousser MG. Headache as the only neurological sign of cerebral venous thrombosis: a series of 17 cases. J Neurol Neurosurg Psychiatry. 2005;76(8):1084–7.
Digre KB. Idiopathic intracranial hypertension headache. Curr Pain Headache Rep. 2002;6(3):217–25.
Almazov I, Brand N. Meningismus is a commonly overlooked finding in tension-type headache in children and adolescents. J Child Neurol. 2006;21(5):423–5.
Calabrese LH, Dodick DW, Schwedt TJ, Singhal AB. Narrative review: reversible cerebral vasoconstriction syndromes. Ann Intern Med. 2007;146(1):34–44.
Chen SP, Fuh JL, Wang SJ, Chang FC, Lirng JF, Fang YC, et al. Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Ann Neurol. 2010;67(5):648–56.
Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 2007;130(Pt 12):3091–101.
Hastriter E, Halker R, Vargas B, Dodick D. Headache prognosis in reversible cerebral vasoconstriction syndrome (RCVS) (abstract). Headache. 2011;51:49.
Silberstein SD. Headaches due to nasal and paranasal sinus disease. Neurol Clin. 2004;22(1):1–19, v.
Mokri B. Headaches in cervical artery dissections. Curr Pain Headache Rep. 2002;6(3):209–16.
Lee JL, Naguwa SM, Cheema GS, Gershwin ME. The geo-epidemiology of temporal (giant cell) arteritis. Clin Rev Allergy Immunol. 2008;35(1–2):88–95.
Salvarani C, Hunder GG. Giant cell arteritis with low erythrocyte sedimentation rate: frequency of occurrence in a population-based study. Arthritis Rheum. 2001;45(2):140–5.
Rozen TD. Intranasal contact point headache: missing the “point” on brain MRI. Neurology. 2009;72(12):1107.
Al-Araji A, Kidd DP. Neuro-Behcet’s disease: epidemiology, clinical characteristics, and management. Lancet Neurol. 2009;8(2):192–204.
Evans RW, Seifert TD. The challenge of new daily persistent headache. Headache. 2011;51(1):145–54.
Nierenburg H, Newman LC. Update on new daily persistent headache. Curr Treat Options Neurol. 2016;18(6):25.
Hamada T, Ohshima K, Ide Y, Sakato S, Takamori M. A case of new daily persistent headache with elevated antibodies to Epstein-Barr virus. Jpn J Med. 1991;30(2):161–3.
Takase Y, Nakano M, Tatsumi C, Matsuyama T. Clinical features, effectiveness of drug-based treatment, and prognosis of new daily persistent headache (NDPH): 30 cases in Japan. Cephalalgia. 2004;24(11):955–9.
Meineri P, Torre E, Rota E, Grasso E. New daily persistent headache: clinical and serological characteristics in a retrospective study. Neurol Sci. 2004;25(Suppl 3):S281–2.
Baron EP, Rothner AD. New daily persistent headache in children and adolescents. Curr Neurol Neurosci Rep. 2010;10(2):127–32.
Rozen T. Successful treatment of new daily persistent headache with gabapentin and topiramate. Headache. 2002;42(4):389.
Evans RW, Rozen TD. Etiology and treatment of new daily persistent headache. Headache. 2001;41(8):830–2.
Rozen T. Doxycycline for treatment resistant new daily persistent headache. Neurology. 2008;70(Suppl 1):A348.
Rozen TD. New daily persistent headache: clinical perspective. Headache. 2011;51(4):641–9.
Marmura MJ, Passero FC Jr, Young WB. Mexiletine for refractory chronic daily headache: a report of nine cases. Headache. 2008;48(10):1506–10.
Prakash S, Shah ND. Post-infectious new daily persistent headache may respond to intravenous methylprednisolone. J Headache Pain. 2010;11(1):59–66.
Prakash S, Saini S, Rana KR, Mahato P. Refining clinical features and therapeutic options of new daily persistent headache: a retrospective study of 63 patients in India. J Headache Pain. 2012;13(6):477–85.
Silberstein SD, Silberstein JR. Chronic daily headache: long-term prognosis following inpatient treatment with repetitive IV DHE. Headache. 1992;32(9):439–45.
Eller M, Gelfand A, Riggins N, Goadsby P. An inpatient course of intravenous dihydroergotamine use for new daily persistent headache. Neurology. 2014;82(10 Suppl):P7.180.
Nagy AJ, Gandhi S, Bhola R, Goadsby PJ. Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Neurology. 2011;77(20):1827–32.
Afridi SK, Shields KG, Bhola R, Goadsby PJ. Greater occipital nerve injection in primary headache syndromes--prolonged effects from a single injection. Pain. 2006;122(1–2):126–9.
Spears RC. Efficacy of botulinum toxin type A in new daily persistent headache. J Headache Pain. 2008;9(6):405–6.
Joshi SG, Mathew PG, Markley HG. New daily persistent headache and potential new therapeutic agents. Curr Neurol Neurosci Rep. 2014;14(2):425.
Trucco M, Ruiz L. P009. A case of new daily persistent headache treated with botulinum toxin type A. J Headache Pain. 2015;16(Suppl 1):A119.
Tarshish S, Robbins M, Napchan U, Buse D, Grosberg B. Prophylaxis of new daily persistent headache (NDPH): response to clonazepam in four patients [abstract]. Cephalalgia. 2009;29(Suppl. 1):49.
Rozen TD, Beams JL. New daily persistent headache with a thunderclap headache onset and complete response to nimodipine (a new distinct subtype of NDPH). J Headache Pain. 2013;14:100.
Rapoport AM, Bigal ME, Volcy M, Sheftell FD, Feleppa M, Tepper SJ. Naratriptan in the preventive treatment of refractory chronic migraine: a review of 27 cases. Headache. 2003;43(5):482–9.
Sheftell FD, Rapoport AM, Tepper SJ, Bigal ME. Naratriptan in the preventive treatment of refractory transformed migraine: a prospective pilot study. Headache. 2005;45(10):1400–6.
Gallagher RM, Mueller L. Managing intractable migraine with naratriptan. Headache. 2003;43(9):991–3.
Ruff RL, Ruff SS, Wang XF. Improving sleep: initial headache treatment in OIF/OEF veterans with blast-induced mild traumatic brain injury. J Rehabil Res Dev. 2009;46(9):1071–84.
Wintrich S, Rothner D. New daily persistent headaches-follow up and outcome in children and adolescents. Headache. 2010;50(Suppl. 1):s23.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Natbony, L.R., Sheikh, H.U., Green, M.W. (2019). New Daily Persistent Headache. In: Green, M., Cowan, R., Freitag, F. (eds) Chronic Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-91491-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-91491-6_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-91490-9
Online ISBN: 978-3-319-91491-6
eBook Packages: MedicineMedicine (R0)