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Chronic Headache pp 217–230Cite as

Pharmacologic Approaches to CDH: Evidence and Outcomes

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Abstract

Chronic daily headache (CDH) is a highly prevalent condition that severely affects patient’s lives. Most patients with CDH experience chronic migraine (CM). The management of these patients is complex and includes acute and preventive pharmacological treatment. In CDH, the use of acute medication should be restricted to avoid the risk of medication-overuse headache. However, the use of preventive medication should be considered in all patients with CDH. There are few studies investigating the role of preventives in CDH, and the majority have CM. Topiramate and onabotulinumtoxinA are the only two drugs with proved scientific evidence in the prevention of CM. There are other neuromodulators, beta-blockers, calcium channel blockers, or antidepressants useful in the management of this population of patients. We will present evidence for the efficacy of each drug and for recommended use.

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Authors and Affiliations

  1. Department of Neurology, Neurology Service, University Clinical Hospital, Catholic University of Valencia, Valencia, Spain

    Miguel J. A. Láinez

  2. Neurology Service, University Clinical Hospital, Catholic University of Valencia, Valencia, Spain

    Ane Mínguez-Olaondo

Authors
  1. Miguel J. A. Láinez
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  2. Ane Mínguez-Olaondo
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Correspondence to Miguel J. A. Láinez .

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Editors and Affiliations

  1. Department of Headache and Pain Medicine, Icahn School of Medicine at Mt. Sinai, Department of Headache and Pain Medicine, New York, NY, USA

    Mark W. Green

  2. Neurology & Neurological Sciences, Stanford School of Medicine Neurology & Neurological Sciences, Stanford, CA, USA

    Robert Cowan

  3. Department of Neurology, Medical College of Wisconsin, Department of Neurology, Milwaukee, WI, USA

    Frederick G. Freitag

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Láinez, M.J.A., Mínguez-Olaondo, A. (2019). Pharmacologic Approaches to CDH: Evidence and Outcomes. In: Green, M., Cowan, R., Freitag, F. (eds) Chronic Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-91491-6_16

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  • DOI: https://doi.org/10.1007/978-3-319-91491-6_16

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  • Online ISBN: 978-3-319-91491-6

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