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Chronic Heart Failure Abolishes Circadian Rhythms in Resting and Chemoreflex Breathing

  • Robert LewisEmail author
  • Bryan T. Hackfort
  • Harold D. Schultz
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1071)

Abstract

Physiological systems often display 24 h rhythms that vary with the light/dark cycle. Disruption of circadian physiological rhythms have been linked to the progression of various cardiovascular diseases, and advances in the understanding of these rhythms have led to novel interventions and improved clinical outcomes. Although respiratory function has been known to vary between the light and dark periods, circadian rhythms in breathing have been understudied in clinical conditions. In the current study, we have begun to assess light/dark variations in respiration in chronic heart failure (CHF), a condition associated with abnormal resting and chemoreflex breathing as well as exercise intolerance. CHF was induced using coronary artery ligation and verified using echocardiography. Sham animals underwent a thoracotomy without coronary artery ligation. Tidal volume, respiratory frequency, and minute ventilation were all determined by whole body plethysmography under resting conditions and in response to chemoreflex challenges during the light and dark periods. Light/dark differences in voluntary exercise were assessed using a running wheel. The sham control group showed light/dark differences in resting and chemoreflex breathing, as well as arterial pressure, and these effects were eliminated in the CHF group. Both groups completed more rotations on the running wheel during the dark period compared to during the light period. The data suggest that CHF disrupts cardiovascular and respiratory circadian rhythms.

Keywords

Circadian rhythm Chronic heart failure Chronobiology Plethysmography 

Notes

Acknowledgements

The authors would like to acknowledge Mary Ann Zink and Kaye Talbitzer for their technical assistance in completing this project.

This work was supported by NIH PO1-HL062222-17.

References

  1. Andrade DC, Lucero C, Toledo C, Madrid C, Marcus NJ, Schultz HD, Del Rio R (2015) Relevance of the carotid body Chemoreflex in the progression of heart failure. Biomed Res Int 2015:467597.  https://doi.org/10.1155/2015/467597 CrossRefPubMedPubMedCentralGoogle Scholar
  2. Ayala DE, Moya A, Crespo JJ, Castineira C, Dominguez-Sardina M, Gomara S, Sineiro E, Mojon A, Fontao MJ, Hermida RC, Hygia Project I (2013) Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes. Chronobiol Int 30(1–2):99–115.  https://doi.org/10.3109/07420528.2012.701489 CrossRefPubMedGoogle Scholar
  3. Chen Y, Tjong YW, Ip SF, Tipoe GL, Fung ML (2005) Melatonin enhances the hypoxic response of rat carotid body chemoreceptor. J Pineal Res 38(3):157–163.  https://doi.org/10.1111/j.1600-079X.2004.00187.x CrossRefPubMedGoogle Scholar
  4. Del Rio R, Marcus NJ, Schultz HD (2013) Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure. J Appl Physiol 114(9):1141–1150.  https://doi.org/10.1152/japplphysiol.01503.2012 CrossRefPubMedPubMedCentralGoogle Scholar
  5. Durgan DJ, Young ME (2010) The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res 106(4):647–658.  https://doi.org/10.1161/circresaha.109.209957 CrossRefPubMedPubMedCentralGoogle Scholar
  6. Floras JS, Jones JV, Johnston JA, Brooks DE, Hassan MO, Sleight P (1978) Arousal and the circadian rhythm of blood pressure. Clin Sci Mol Med 55(Suppl 4):395s–397sGoogle Scholar
  7. Grivas TB, Savvidou OD (2007) Melatonin the “light of night” in human biology and adolescent idiopathic scoliosis. Scoliosis 2:6.  https://doi.org/10.1186/1748-7161-2-6 CrossRefPubMedPubMedCentralGoogle Scholar
  8. Komori T, Eguchi K, Saito T, Hoshide S, Kario K (2016) Riser pattern: another determinant of heart failure with preserved ejection fraction. J Clin Hypertens (Greenwich) 18(10):994–999.  https://doi.org/10.1111/jch.12818 CrossRefGoogle Scholar
  9. Lynch HJ, Deng MH, Wurtman RJ (1984) Light intensities required to suppress nocturnal melatonin secretion in albino and pigmented rats. Life Sci 35(8):841–847CrossRefGoogle Scholar
  10. Morrissey RP, Czer L, Shah PK (2011) Chronic heart failure. Am J Cardiovasc Drugs 11(3):153–171.  https://doi.org/10.2165/11592090-000000000-00000 CrossRefPubMedGoogle Scholar
  11. Mortola JP (2004) Breathing around the clock: an overview of the circadian pattern of respiration. Eur J Appl Physiol 91(2–3):119–129.  https://doi.org/10.1007/s00421-003-0978-0 CrossRefPubMedGoogle Scholar
  12. Mortola JP, Seifert EL (2002) Circadian patterns of breathing. Respir Physiol Neurobiol 131(1–2):91–100CrossRefGoogle Scholar
  13. Mousa TM, Schiller AM, Zucker IH (2014) Disruption of cardiovascular circadian rhythms in mice post myocardial infarction: relationship with central angiotensin II receptor expression. Physiol Rep 2(11).  https://doi.org/10.14814/phy2.12210 CrossRefGoogle Scholar
  14. Partch CL, Green CB, Takahashi JS (2014) Molecular architecture of the mammalian circadian clock. Trends in Cell Biol 24(2):90–99.  https://doi.org/10.1016/j.tcb.2013.07.002 CrossRefGoogle Scholar
  15. Peever JH, Stephenson R (1997) Day-night differences in the respiratory response to hypercapnia in awake adult rats. Respir Physiol 109(3):241–248CrossRefGoogle Scholar
  16. Piepoli MF, Crisafulli A (2014) Pathophysiology of human heart failure: importance of skeletal muscle myopathy and reflexes. Exp Physiol 99(4):609–615.  https://doi.org/10.1113/expphysiol.2013.074310 CrossRefPubMedGoogle Scholar
  17. Saiki C, Mortola JP (1995) Hypoxia abolishes the morning-night differences of metabolism and ventilation in 6-day-old rats. Can J Physiol Pharmacol 73(1):159–164CrossRefGoogle Scholar
  18. Seifert EL, Mortola JP (2002) Circadian pattern of ventilation during prolonged hypoxia in conscious rats. Respir Physiol Neurobiol 133(1–2):23–34CrossRefGoogle Scholar
  19. Tjong YW, Chen Y, Liong EC, Tipoe GL, Fung ML (2006) Chronic hypoxia modulates the function and expression of melatonin receptors in the rat carotid body. J Pineal Res 40(2):125–134.  https://doi.org/10.1111/j.1600-079X.2005.00286.x CrossRefPubMedGoogle Scholar
  20. Tsimakouridze EV, Alibhai FJ, Martino TA (2015) Therapeutic applications of circadian rhythms for the cardiovascular system. Front Pharmacol 6:77.  https://doi.org/10.3389/fphar.2015.00077 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Robert Lewis
    • 1
    Email author
  • Bryan T. Hackfort
    • 2
  • Harold D. Schultz
    • 2
  1. 1.A.T. Still University School of Osteopathic MedicineMesaUSA
  2. 2.Department of Cellular and Integrative Physiology at the University of Nebraska Medical CenterOmahaUSA

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