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Pertussis and Pertussis Syndrome

a whooping cough

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Abstract

Pertussis or whooping cough is an acute infection of the respiratory tract caused by the Gram-negative bacterium, Bordetella pertussis. The disease remains a major public health problem worldwide and affects persons of all ages; however, it is most severe in the infant population less than 4 months of age. This chapter reviews the definition, epidemiology, stages, symptoms, and complications of pertussis disease, describes the most accurate method to test for infection, lists the differential diagnosis for pertussis-like illness, and reviews the most effective antibiotics for its treatment and prevention. An overview of available pertussis-containing vaccines and the current recommendations for their use in different age groups are also presented.

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Further Reading

  • CDC. Recommended antimicrobial agents for the treatment and postexposure prophylaxis of pertussis. 2005 CDC guidelines. MMWR Recomm Rep. 2005;54(RR-14):1–15.

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  • CDC. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women – Advisory Committee on Immunization Practices (ACIP), 2012. MMWR Morb Mortal Wkly Rep. 2013;62(07):131–5.

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  • Clark TA. Changing pertussis epidemiology: everything old is new again. J Infect Dis. 2014;209:978–81.

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  • Forsyth K, Plotkin S, Tan T, et al. Strategies to decrease pertussis transmission to infants. Pediatrics. 2015;135:e1475.

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  • Kilgore PE, Salim AM, Zervos MJ, et al. Pertussis: microbiology, disease, treatment, and prevention. Clin Microbiol Rev. 2016;29(3):449–86.

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  • Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella species. Clin Microbiol Rev. 2005;18(2):326–82.

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  • Tan TQ, Dalby T, Forsyth K, et al. Pertussis across the globe: recent epidemiologic data. Pediatr Infect Dis J. 2015;34(9):e222–32.

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Related Links to Journals, Books, and/or URLS

  • Cherry JD, Heininger U. Pertussis and other Bordetella infections. In: Cherry JD, Demmler-Harrison GJ, Kaplan SL, Hotez P, Steinbach WJ, editors. Feigin and Cherry’s textbook of pediatric infectious diseases. 7th ed. Philadelphia: Elsevier Saunders; 2014. p. 1616–39.

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  • Waters V, Halperin SA. Bordetella pertussis. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett’s Principles and practice of infectious diseases. 8th ed. Philadelphia: Elsevier Saunders; 2015. p. 2619–28.

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  • www.cdc.gov/pertussis/index.html

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Correspondence to Tina Q. Tan .

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Tan, T.Q. (2019). Pertussis and Pertussis Syndrome. In: Domachowske, J. (eds) Introduction to Clinical Infectious Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-91080-2_6

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  • DOI: https://doi.org/10.1007/978-3-319-91080-2_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-91079-6

  • Online ISBN: 978-3-319-91080-2

  • eBook Packages: MedicineMedicine (R0)

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