The efforts of many scientists are directed to study of heart electrical instability by experimental methods and mathematical modeling of cardiomyocytes’ functional properties. The development of arrhythmias can be caused by cardiac beat-to-beat alternations in action potential duration (APD), concentration of intracellular Ca2+ and contraction force. One of the methods for investigation of dangerous arrhythmias genesis is based on the restitution hypothesis.
Motivated by theoretical foundations and experimental research of the arrhythmias, the new approach to stimulation of action potential (AP) alternans in cardiomyocytes due to the heart rate variability was proposed. The main attention was paid to study of electrical restitution dynamics of cardiomyocytes using several pacing protocols. Computational simulation of the action potential and currents for potassium, sodium, calcium ions in cardiomyocytes was carried out using parallel conductance model. Numerical experiments, performed in Matlab environment, allowed us to study electrical properties of cardiomyocytes. The occurrence of APD alternans in areas of electrical restitution curve with a maximum slope is presented.
Cardiomyocyte Action potential Parallel conductance model Electrical restitution Alternans
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The study was supported by EU-financed Horizon 2020 project AMMODIT (Approximation Methods for Molecular Modeling and Diagnosis Tools) - Grant Number MSCA-RISE 645672.
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