Abstract
A 16-year-old African American male with sickle cell anemia is admitted to the hospital with worsening chest pain, shortness of breath, and fever (temperature 39.0 °C). Bilateral lower lobe infiltrates are seen on chest X-ray, and the patient’s oxygen saturation on room air is 88%. The patient’s hemoglobin (Hgb) level is 6.2 g/dL (his baseline Hgb is 7.5 g/dL). The patient has not been seen in your hospital prior to this admission, but the patient does report a history of blood transfusions, including several units of red blood cells (RBCs) transfused 2 months ago for severe pain while traveling abroad. An ethylenediaminetetraacetic acid (EDTA) anticoagulant sample is submitted to the blood bank for type and screen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Schwartz J, Padmanbhan A, Aqui N, Balogun RA, Connelly-Smith L, Delaney M, et al. Guidelines on the use of therapeutic apheresis in clinical practice-Evidence-based approach from the writing committee of the American Society of Apheresis: the seventh special issue. J Clin Apher. 2016;305–6.
Brown DJ. A rapid method for harvesting autologous red cells from patients with hemoglobin S disease. Transfusion. 1988;28(1):21–3.
Sapatnekar S. Molecular typing for red blood cell antigens. AACC. 2015. https://www.aacc.org/publications/cln/articles/2015/march/molecular-typing-for-red-blood-cell-antigens Accessed 23 Dec 2017.
Paccapelo C, Truglio F, Villa MA, Rivelli N, Marconi M. HEA BeadChip™ technology in immunohematology. Immunohematology. 2015;31(2):81–90.
Fichou Y, Mariez M, Le Maréchal C, Feréc C. The experience of extended blood group genotyping by next-generation sequencing (NGS): investigation of patients with sickle-cell disease. Vox Sang. 2016;111(4):418–24.
Schoeman EM, Roulis EV, Liew Y-W, Martin JR, Powley T, Wilson B, et al. Targeted exome sequencing defines novel and rare variants in complex blood group serology cases for a red blood cell reference laboratory setting. Transfusion. 2018;58(2):284–93.
Recommended Reading
Casas J, Friedman DF, Jackson T, Vege S, Westhoff CM, Chou ST. Changing practice: red blood cell typing by molecular methods for patients with sickle cell disease. Transfusion. 2015;55(6 Pt 2):1388–93.
Keller MA. The role of red cell genotyping in transfusion medicine. Immunohematology. 2015;31(2):49–52.
Montemayor-Garcia C, Westhoff CM. The “next-generation” reference laboratory? Transfusion. 2018;58(2):277–9.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Jhang, J.S. (2018). Gene Genius. In: Immunohematology and Transfusion Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-90960-8_30
Download citation
DOI: https://doi.org/10.1007/978-3-319-90960-8_30
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-90959-2
Online ISBN: 978-3-319-90960-8
eBook Packages: MedicineMedicine (R0)