Abstract
While the incidence of developing inflammatory bowel disease does not increase during pregnancy, exacerbations of existing IBD often occur in pregnant women. Treatment decisions must take into account not only the possible negative effects on the mother but also the implications for the pregnancy as well as adverse effects on the fetus. Over the last two decades, there have been significant advances in the medical management of IBD which includes both ulcerative colitis and Crohn’s disease. The most significant of these has been the use of tumor necrosis factor inhibitors and other monoclonal antibodies which have been used effectively and relatively safely during pregnancy. Despite these advances, complications of both ulcerative colitis and Crohn’s disease can develop which require surgical intervention. The nature of these complications often differs between ulcerative colitis and Crohn’s disease, and a thorough understanding of the surgical options is necessary to maximize clinical outcomes and preserve appropriate future treatment options. In this chapter we discuss appropriate medical management for IBD to try to avoid surgical intervention during pregnancy as well as the myriad of clinical presentations of IBD which require surgery and the appropriate surgical management to maximize outcomes for both the mother and fetus.
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References
Ellul P, Zammita S, Katsanos K, Cesarini M, Allocca M, Danese S, et al. Perception of reproductive health in women with inflammatory bowel disease. J Crohns Colitis. 2016;10(8):886–91.
de Lima-Karagiannis A, Zelinkova-Detkova Z, van der Woude C. The effects of active IBD during pregnancy in the era of novel IBD therapies. Am J Gastroenterol. 2016;111(9):1305–12.
Bröms G, Granath F, Stephansson O, Kieler H. Preterm birth in women with inflammatory bowel disease—the association with disease activity and drug treatment. Scand J Gastroenterol. 2016;51(12):1462–9.
Kokoszko-Bilska A, Sobkiewicz S, Fichna J. Inflammatory bowel diseases and reproductive health. Pharmacol Rep. 2016;68(4):859–64.
Minami N, Matsuura M, Koshikawa Y, Yamada S, Honzawa Y, Yamamoto S, et al. Maternal and fetal outcomes in pregnant Japanese women with inflammatory bowel disease: our experience with a series of 23 cases. Intest Res. 2017;15(1):90.
Gaidos J, Kane S. Overcoming challenges of treating inflammatory bowel disease in pregnancy. Expert Rev Clin Immunol. 2016;12(8):871–8.
Mahadevan U, Vermeire S, Lasch K, Abhyankar B, Bhayat F, Blake A, et al. Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease. Aliment Pharmacol Ther. 2017;45(7):941–50.
Gaidos J, Kane S. Managing IBD therapies in pregnancy. Curr Treat Option Gastroenterol. 2017;15(1):71–83.
Cortes X, Borrás-Blasco J, Antequera B, Fernandez-Martinez S, Casterá E, Martin S, et al. Ustekinumab therapy for Crohn's disease during pregnancy: a case report and review of the literature. J Clin Pharm Ther. 2016;42(2):234–6.
Philip MM, Ross HM. IBD diagnosis and evaluation. In: Steele S, Hull T, Reed T, Saclarides T, Senegore A, Whitlow C, editors. The ASCRS textbook of surgery. Third Edition. New York: Springer; 2016. p. 771–86. Print.
Poturoglu S, Ormeci A, Duman A. Treatment of pregnant women with a diagnosis of inflammatory bowel disease. World J Gastrointest Pharmacol Ther. 2016;7(4):490.
Protic M, Markovic S, Tarabar D. Case report: acute flair of ulcerative colitis during pregnancy is still a major problem. Dig Dis. 2017;35(1–2):134–8.
Killeen S, Gunn J, Hartley J. Surgical management of complicated and medically refractory inflammatory bowel disease during pregnancy. Color Dis. 2017;19(2):123–38.
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Ambroze, W.L., Champagne, B.P. (2019). Surgical Management of Inflammatory Bowel Disease in Pregnancy. In: Nezhat, C., Kavic, M., Lanzafame, R., Lindsay, M., Polk, T. (eds) Non-Obstetric Surgery During Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-319-90752-9_14
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DOI: https://doi.org/10.1007/978-3-319-90752-9_14
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