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Heat Shock Proteins in Oxidative and Nitrosative Stress

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Heat Shock Proteins and Stress

Part of the book series: Heat Shock Proteins ((HESP,volume 15))

Abstract

Multiple human pathologies have been attributed to oxidative/nitrosative stress. Stress occurs when the production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) exceeds the antioxidant capacity. Heat shock proteins (HSP) are closely related families of constitutively expressed and stress-induced cellular proteins that protect cellular homeostasis against heat and other stress stimuli. Oxidative stress is considered a key mediator of HSP induction. This chapter reviews the role of Hsp70 in different disorders associated with oxidative/nitrosative stress with reference to factors affecting Hsp70 gene expression, the role of proteasomes, the anti-apoptotic and anti-inflammatory effects and the relation between heat stress and oxidative stress. Moreover, we address the overexpression of other HSP such as Hsp32, 27, 40 and 60 following oxidative/nitrosative stress.

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Abbreviations

Ag NP:

Silver nanoparticles

ARE:

Antioxidant responsive element

HBA:

Heat shock protein 90-binding agent

HO-1:

Heme oxygenase-1

HSE:

Heat shock elements

HSF:

Heat shock factor

HSP:

Heat shock proteins

I/R:

Ischemia/reperfusion

iNOS or NOS II:

Inducible nitric-oxide synthase

NF-κB:

Nuclear factor kappa beta

NO:

Nitric oxide

NOS I/PKG:

Nitric-oxide synthase I/ protein kinase G

ONHs:

Optic nerve heads

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

RVLM:

Rostral ventrolateral medulla

TNF:

Tumor necrosis factor

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Acknowledgements

The authors would like to thank the support from Histology and Cell Biology Department, Faculty of Medicine, Zagazig University. We also thank many lab members and colleagues for critical and productive collaborations.

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Authors and Affiliations

  1. Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Asmaa A. A. A. Kattaia, Samia A. Abd El-Baset & Eman M. Mohamed

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  1. Asmaa A. A. A. Kattaia
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  2. Samia A. Abd El-Baset
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  3. Eman M. Mohamed
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Editors and Affiliations

  1. College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer, Houston, TX, USA

    Punit Kaur

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Kattaia, A.A.A.A., Abd El-Baset, S.A., Mohamed, E.M. (2018). Heat Shock Proteins in Oxidative and Nitrosative Stress. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins and Stress. Heat Shock Proteins, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-90725-3_7

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