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Heat Shock-Induced Transcriptional and Translational Arrest in Mammalian Cells

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Heat Shock Proteins and Stress

Part of the book series: Heat Shock Proteins ((HESP,volume 15))

Abstract

The heat shock response is a highly conserved cellular stress response pathway that protects cells against stress-induced damages. The heat shock response is characterized by the activation of the heat shock factor, a transcription factor, which in turn regulate the expression of heat shock proteins which help the cells to recover from the stress-induced damages. While the mechanism behind the activation of heat shock factor and the expression of heat shock proteins are well studied, our understanding on the other aspects of the heat shock response pathway – mainly the global suppression of transcriptional and the translational processes – has been very limited. Thus, this chapter would focus more on the recent studies elucidating the mechanism behind the heat shock-induced transcriptional and post-transcriptional repression of gene expression. Given the importance of the stress response pathways in cell survival, the chapter would focus on the discoveries made in the mammalian systems and their impact on human health and disease.

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Acknowledgements

Subramaniam Ganesh is a Tata Innovation Fellow and P.K. Kelkar Endowed Chair Professor at IIT Kanpur. Research work on cellular stress response in his laboratory is supported by the Department of Biotechnology, Govt. of India (Grant Number: BT/HRD/35/01/01/2017). Rashmi Parihar is a SERB Young Scientists and is supported by a research grant from the Science and Engineering Research Board, Govt. of India (Grant Number: YSS/2015/001818).

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  1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India

    Anshika Goenka, Rashmi Parihar & Subramaniam Ganesh

  2. Syngene International Ltd., Biocon Park, Bengaluru, India

    Anshika Goenka

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Correspondence to Subramaniam Ganesh .

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  1. College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer, Houston, TX, USA

    Punit Kaur

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Goenka, A., Parihar, R., Ganesh, S. (2018). Heat Shock-Induced Transcriptional and Translational Arrest in Mammalian Cells. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins and Stress. Heat Shock Proteins, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-90725-3_12

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