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Molecular Chaperones and the Nuclear Response to Stress

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Heat Shock Proteins and Stress

Part of the book series: Heat Shock Proteins ((HESP,volume 15))

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Abstract

Chaperones are a well conserved class of proteins that reside in many different cellular compartments. The nucleus is a compartment of special interest because it houses the genetic material and allows for the expression and maintenance of genes. Many chaperones localize to the nucleus under stress conditions. The current body of evidence indicates that the nuclear function of chaperones is similar to chaperone function in the cytoplasm. Emerging evidence on the nuclear import pathway for chaperones suggests that novel pathways exist that allow chaperones to enter the nucleus under conditions of environmental stress. One such pathway, the Hikeshi pathway, is responsible for the transport of HSP70 and possibly other molecular chaperones.

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Acknowledgements

The authors would like to acknowledge the community of researchers whose excellent work has brought us to our current understanding of the stress response. We have tried to site the current research regarding the nuclear stress response and we apologize to any researchers whose work might not have been included in this chapter.

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Authors and Affiliations

  1. Department of Biology, Middle Tennessee State University, Murfreesboro, TN, USA

    Lynn Boyd & Katherine M. Sampuda

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  1. Lynn Boyd
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  2. Katherine M. Sampuda
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Correspondence to Lynn Boyd .

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Editors and Affiliations

  1. College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer, Houston, TX, USA

    Punit Kaur

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Boyd, L., Sampuda, K.M. (2018). Molecular Chaperones and the Nuclear Response to Stress. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins and Stress. Heat Shock Proteins, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-90725-3_1

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