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Microbiome and Diseases: Allergy

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The Gut Microbiome in Health and Disease

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Abstract

The increasing prevalence of allergies and atopic diseases is contrasted by a yet unmet goal of prevention and treatment of allergic diseases. Allergies and atopic diseases develop and manifest at surface organs, which are inhabited by a specific composition of a microbiome. Consequently, the interdependence of microbial colonization of surface organs and the development of allergic/atopic diseases orchestrating either immune tolerance or immune hyperreactivity are a focus of research. This chapter will focus on what is known about the gut microbiota regulating atopic/allergic diseases and shortly allude to a possible role of microbiomes beyond the gut in regulating these diseases. Three prototypic diseases will be covered: food allergy, atopic dermatitis, and allergic asthma. As many functional analyses were performed in the murine system, these will be discussed and complemented with studies in humans, in some cases with appropriate interventional trials.

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References

  • Aagaard, K., Riehle, K., Ma, J., Segata, N., Mistretta, T. A., Coarfa, C., Raza, S., et al. (2012). A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS One, 7, e36466.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Abrahamsson, T. R., Jakobsson, H. E., Andersson, A. F., Bjorksten, B., Engstrand, L., & Jenmalm, M. C. (2012). Low diversity of the gut microbiota in infants with atopic eczema. Journal of Allergy and Clinical Immunology, 129, 434–440 440 e431–432.

    Article  PubMed  Google Scholar 

  • Accordini, S., Corsico, A. G., Braggion, M., Gerbase, M. W., Gislason, D., Gulsvik, A., Heinrich, J., et al. (2013). The cost of persistent asthma in Europe: An international population-based study in adults. International Archives of Allergy and Immunology, 160, 93–101.

    Article  PubMed  Google Scholar 

  • Adlerberth, I., Strachan, D. P., Matricardi, P. M., Ahrne, S., Orfei, L., Aberg, N., Perkin, M. R., et al. (2007). Gut microbiota and development of atopic eczema in 3 European birth cohorts. The Journal of Allergy and Clinical Immunology, 120, 343–350.

    Article  PubMed  CAS  Google Scholar 

  • Agrawal, R., & Woodfolk, J. A. (2014). Skin barrier defects in atopic dermatitis. Current Allergy and Asthma Reports, 14, 433.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Aitoro, R., Paparo, L., Amoroso, A., Di Costanzo, M., Cosenza, L., Granata, V., Di Scala, C., et al. (2017). Gut microbiota as a target for preventive and therapeutic intervention against food allergy. Nutrients, 9, E672.

    Article  PubMed  Google Scholar 

  • Arrieta, M. C., Stiemsma, L. T., Dimitriu, P. A., Thorson, L., Russell, S., Yurist-Doutsch, S., Kuzeljevic, B., et al. (2015). Early infancy microbial and metabolic alterations affect risk of childhood asthma. Science Translational Medicine, 7, 307ra152.

    Article  PubMed  CAS  Google Scholar 

  • Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., et al. (2013). Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature, 500, 232–236.

    Article  PubMed  CAS  Google Scholar 

  • Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., et al. (2011). Induction of colonic regulatory T cells by indigenous Clostridium species. Science, 331, 337–341.

    Article  PubMed  CAS  Google Scholar 

  • Azad, M. B., Konya, T., Maughan, H., Guttman, D. S., Field, C. J., Sears, M. R., Becker, A. B., et al. (2013). Infant gut microbiota and the hygiene hypothesis of allergic disease: Impact of household pets and siblings on microbiota composition and diversity. Allergy, Asthma and Clinical Immunology, 9, 15.

    Article  Google Scholar 

  • Baker, B. S. (2006). The role of microorganisms in atopic dermatitis. Clinical and Experimental Immunology, 144, 1–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ball, T. M., Castro-Rodriguez, J. A., Griffith, K. A., Holberg, C. J., Martinez, F. D., & Wright, A. L. (2000). Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. The New England Journal of Medicine, 343, 538–543.

    Article  PubMed  CAS  Google Scholar 

  • Bashir, M. E., Louie, S., Shi, H. N., & Nagler-Anderson, C. (2004). Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. Journal of Immunology, 172, 6978–6987.

    Article  CAS  Google Scholar 

  • Bassis, C. M., Tang, A. L., Young, V. B., & Pynnonen, M. A. (2014). The nasal cavity microbiota of healthy adults. Microbiome, 2, 27.

    Article  PubMed  PubMed Central  Google Scholar 

  • Baurecht, H., Rühlemann, M. C., Rodríguez, E., Thielking, F., Harder, I., Erkens, A. S., Stölzl, D., Ellinghaus, E., Hotze, M., Lieb, W., Wang, S., Heinsen, F. A., Franke, A., & Weidinger, S. (2018). Epidermal lipid composition, barrier integrity and eczematous inflammation are associated with skin microbiome configuration. The Journal of Allergy and Clinical Immunology. pii: S0091-6749(18)30198-2. https://doi.org/10.1016/j.jaci.2018.01.019.

  • Beck, T. C., Gomes, A. C., Cyster, J. G., & Pereira, J. P. (2014). CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. The Journal of Experimental Medicine, 211, 2567–2581.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Beck, J. M., Young, V. B., & Huffnagle, G. B. (2012). The microbiome of the lung. Translational Research, 160, 258–266.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Belkaid, Y., & Harrison, O. J. (2017). Homeostatic immunity and the microbiota. Immunity, 46, 562–576.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bergmann, K.-C., & Ring, J. (2014). History of allergy. Chemical Immunology and Allergy, 100, 54–61.

    Article  PubMed  Google Scholar 

  • Berin, M. C., Zheng, Y., Domaradzki, M., Li, X. M., & Sampson, H. A. (2006). Role of TLR4 in allergic sensitization to food proteins in mice. Allergy, 61, 64–71.

    Article  PubMed  CAS  Google Scholar 

  • Berni Canani, R., Nocerino, R., Terrin, G., Coruzzo, A., Cosenza, L., Leone, L., & Troncone, R. (2012). Effect of Lactobacillus GG on tolerance acquisition in infants with cow’s milk allergy: A randomized trial. Journal of Allergy and Clinical Immunology, 129, 580–582.e585.

    Article  PubMed  Google Scholar 

  • Berthon, B. S., Macdonald-Wicks, L. K., Gibson, P. G., & Wood, L. G. (2013). Investigation of the association between dietary intake, disease severity and airway inflammation in asthma. Respirology, 18, 447–454.

    Article  PubMed  Google Scholar 

  • Biedermann, T. (2006). Dissecting the role of infections in atopic dermatitis. Acta Dermato-Venereologica, 86, 99–109.

    PubMed  CAS  Google Scholar 

  • Biedermann, T., Röcken, M., & Carballido, J. M. (2004). TH1 and TH2 lymphocyte development and regulation of TH cell-mediated immune responses of the skin. The Journal of Investigative Dermatology. Symposium Proceedings, 9, 5–14.

    Article  PubMed  CAS  Google Scholar 

  • Biedermann, T., Skabytska, Y., Kaesler, S., & Volz, T. (2015). Regulation of T cell immunity in atopic dermatitis by microbes: The Yin and Yang of cutaneous inflammation. Frontiers in Immunology, 6, 353.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Brouwer, M. L., Wolt-Plompen, S. A., Dubois, A. E., van der Heide, S., Jansen, D. F., Hoijer, M. A., Kauffman, H. F., et al. (2006). No effects of probiotics on atopic dermatitis in infancy: A randomized placebo-controlled trial. Clinical and Experimental Allergy, 36, 899–906.

    Article  PubMed  CAS  Google Scholar 

  • Bunyavanich, S., Shen, N., Grishin, A., Wood, R., Burks, W., Dawson, P., Jones, S. M., et al. (2016). Early-life gut microbiome composition and milk allergy resolution. The Journal of Allergy and Clinical Immunology, 138, 1122–1130.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cahenzli, J., Koller, Y., Wyss, M., Geuking, M. B., & McCoy, K. D. (2013). Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host & Microbe, 14, 559–570.

    Article  CAS  Google Scholar 

  • Chen, Y., & Blaser, M. J. (2008). Helicobacter pylori colonization is inversely associated with childhood asthma. The Journal of Infectious Diseases, 198, 553–560.

    Article  PubMed  Google Scholar 

  • Chen, C. C., Chen, K. J., Kong, M. S., Chang, H. J., & Huang, J. L. (2016). Alterations in the gut microbiotas of children with food sensitization in early life. Pediatric Allergy and Immunology, 27, 254–262.

    Article  PubMed  Google Scholar 

  • Chu, D. M., Ma, J., Prince, A. L., Antony, K. M., Seferovic, M. D., & Aagaard, K. M. (2017). Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nature Medicine, 23, 314–326.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Clark, S., Espinola, J., Rudders, S. A., Banerji, A., & Camargo, C. A., Jr. (2011). Frequency of US emergency department visits for food-related acute allergic reactions. The Journal of Allergy and Clinical Immunology, 127, 682–683.

    Article  PubMed  Google Scholar 

  • Cohn, L., Elias, J. A., & Chupp, G. L. (2004). Asthma: Mechanisms of disease persistence and progression. Annual Review of Immunology, 22, 789–815.

    Article  PubMed  CAS  Google Scholar 

  • Coombs, R. R. A., & Gells, P. G. H. (1963). The classification of allergic reactions underlying disease. In R. R. A. Coombs & P. G. H. Gells (Eds.), Clinical aspects of immunology. Oxford: Blackwell Science.

    Google Scholar 

  • Curotto de Lafaille, M. A., Kutchukhidze, N., Shen, S., Ding, Y., Yee, H., & Lafaille, J. J. (2008). Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity, 29, 114–126.

    Article  PubMed  CAS  Google Scholar 

  • De Benedetto, A., Agnihothri, R., McGirt, L. Y., Bankova, L. G., & Beck, L. A. (2009). Atopic dermatitis: A disease caused by innate immune defects? The Journal of Investigative Dermatology, 129, 14–30.

    Article  PubMed  CAS  Google Scholar 

  • De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., et al. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America, 107, 14691–14696.

    Article  PubMed  PubMed Central  Google Scholar 

  • du Toit, G., Tsakok, T., Lack, S., & Lack, G. (2016). Prevention of food allergy. The Journal of Allergy and Clinical Immunology, 137, 998–1010.

    Article  PubMed  CAS  Google Scholar 

  • Egawa, G., & Kabashima, K. (2016). Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march. The Journal of Allergy and Clinical Immunology, 138, 350–358.e351.

    Article  PubMed  Google Scholar 

  • Eyerich, K., Eyerich, S., & Biedermann, T. (2015). The multi-modal immune pathogenesis of atopic eczema. Trends in Immunology, 36, 788–801.

    Article  PubMed  CAS  Google Scholar 

  • Eyerich, K., Pennino, D., Scarponi, C., Foerster, S., Nasorri, F., Behrendt, H., Ring, J., Traidl-Hoffmann, C., Albanesi, C., & Cavani, A. (2009). IL-17 in atopic eczema: Linking allergen-specific adaptive and microbial-triggered innate immune response. The Journal of Allergy and Clinical Immunology, 123, 59–66.

    Article  PubMed  CAS  Google Scholar 

  • Fujimura, K. E., Demoor, T., Rauch, M., Faruqi, A. A., Jang, S., Johnson, C. C., Boushey, H. A., et al. (2014). House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proceedings of the National Academy of Sciences of the United States of America, 111, 805–810.

    Article  PubMed  CAS  Google Scholar 

  • Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., et al. (2013). Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature, 504, 446–450.

    Article  CAS  PubMed  Google Scholar 

  • Geuking, M. B., Cahenzli, J., Lawson, M. A., Ng, D. C., Slack, E., Hapfelmeier, S., McCoy, K. D., et al. (2011). Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity, 34, 794–806.

    Article  PubMed  CAS  Google Scholar 

  • Glatz, M., Bosshard, P. P., Hoetzenecker, W., & Schmid-Grendelmeier, P. (2015). The role of Malassezia spp. in atopic dermatitis. Journal of Clinical Medicine, 4, 1217–1228.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gomez-Gallego, C., Garcia-Mantrana, I., Salminen, S., & Collado, M. C. (2016). The human milk microbiome and factors influencing its composition and activity. Seminars in Fetal and Neonatal Medicine, 21, 400–405.

    Article  PubMed  Google Scholar 

  • Grice, E. A., & Segre, J. A. (2011). The skin microbiome. Nature Reviews. Microbiology, 9, 244–253.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gueniche, A., Knaudt, B., Schuck, E., Volz, T., Bastien, P., Martin, R., Röcken, M., et al. (2008). Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled clinical study. The British Journal of Dermatology, 159, 1357–1363.

    Article  PubMed  CAS  Google Scholar 

  • Guenova, E., Skabytska, Y., Hoetzenecker, W., Weindl, G., Sauer, K., Tham, M., Kim, K. W., et al. (2015). IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proceedings of the National Academy of Sciences of the United States of America, 112, 2163–2168.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., Muller, W., et al. (2011). Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity, 34, 237–246.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, J. D., Suarez-Farinas, M., Dhingra, N., Cardinale, I., Li, X., Kostic, A., Ming, J. E., et al. (2014). Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. The Journal of Allergy and Clinical Immunology, 134, 1293–1300.

    Article  PubMed  CAS  Google Scholar 

  • Hartl, D., Koller, B., Mehlhorn, A. T., Reinhardt, D., Nicolai, T., Schendel, D. J., Griese, M., et al. (2007). Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. The Journal of Allergy and Clinical Immunology, 119, 1258–1266.

    Article  PubMed  CAS  Google Scholar 

  • Hill, D. A., Siracusa, M. C., Abt, M. C., Kim, B. S., Kobuley, D., Kubo, M., Kambayashi, T., et al. (2012). Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nature Medicine, 18, 538–546.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hol, J., van Leer, E. H., Elink Schuurman, B. E., de Ruiter, L. F., Samsom, J. N., Hop, W., Neijens, H. J., et al. (2008). The acquisition of tolerance toward cow’s milk through probiotic supplementation: A randomized, controlled trial. The Journal of Allergy and Clinical Immunology, 121, 1448–1454.

    Article  PubMed  CAS  Google Scholar 

  • Holt, P. G. (2015). The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage. The Journal of Allergy and Clinical Immunology, 136, 15–22.

    Article  PubMed  Google Scholar 

  • Igea, J. M. (2013). The history of the idea of allergy. Allergy, 68, 966–973.

    Article  PubMed  CAS  Google Scholar 

  • Irvine, A. D., McLean, W. H., & Leung, D. Y. (2011). Filaggrin mutations associated with skin and allergic diseases. The New England Journal of Medicine, 365, 1315–1327.

    Article  PubMed  CAS  Google Scholar 

  • ISAAC. (1998). Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet, 351, 1225–1232.

    Article  Google Scholar 

  • Isolauri, E., Arvola, T., Sutas, Y., Moilanen, E., & Salminen, S. (2000). Probiotics in the management of atopic eczema. Clinical and Experimental Allergy, 30, 1604–1610.

    Article  PubMed  CAS  Google Scholar 

  • Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P., Chinen, T., Zheng, Y., Umetsu, D. T., et al. (2012). Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature, 482, 395–399.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kaesler, S., Volz, T., Skabytska, Y., Köberle, M., Hein, U., Chen, K. M., Guenova, E., et al. (2014). Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4-mediated suppression of IL-10. The Journal of Allergy and Clinical Immunology, 134, 92–99.

    Article  PubMed  CAS  Google Scholar 

  • Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001). Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. The Journal of Allergy and Clinical Immunology, 107, 129–134.

    Article  PubMed  Google Scholar 

  • Kay, A. B. (2001). Allergy and allergic diseases. First of two parts. The New England Journal of Medicine, 344, 30–37.

    Article  PubMed  CAS  Google Scholar 

  • Keski-Nisula, L., Kyynarainen, H. R., Karkkainen, U., Karhukorpi, J., Heinonen, S., & Pekkanen, J. (2013). Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth. Acta Paediatrica, 102, 480–485.

    Article  PubMed  Google Scholar 

  • Kolokotroni, O., Middleton, N., Gavatha, M., Lamnisos, D., Priftis, K. N., & Yiallouros, P. K. (2012). Asthma and atopy in children born by caesarean section: Effect modification by family history of allergies – a population based cross-sectional study. BMC Pediatrics, 12, 179.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., et al. (2012). Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Research, 22, 850–859.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Korpela, K., Salonen, A., Virta, L. J., Kekkonen, R. A., Forslund, K., Bork, P., & de Vos, W. M. (2016). Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nature Communications, 7, 10410.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kuo, I. H., Yoshida, T., De Benedetto, A., & Beck, L. A. (2013). The cutaneous innate immune response in patients with atopic dermatitis. The Journal of Allergy and Clinical Immunology, 131, 266–278.

    Article  PubMed  CAS  Google Scholar 

  • Lewkowich, I. P., Herman, N. S., Schleifer, K. W., Dance, M. P., Chen, B. L., Dienger, K. M., Sproles, A. A., et al. (2005). CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. The Journal of Experimental Medicine, 202, 1549–1561.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Leyden, J. J., Marples, R. R., & Kligman, A. M. (1974). Staphylococcus aureus in the lesions of atopic dermatitis. The British Journal of Dermatology, 90, 525–530.

    Article  PubMed  CAS  Google Scholar 

  • Ling, Z., Li, Z., Liu, X., Cheng, Y., Luo, Y., Tong, X., Yuan, L., et al. (2014). Altered fecal microbiota composition associated with food allergy in infants. Applied and Environmental Microbiology, 80, 2546–2554.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Liu, H., Archer, N. K., Dillen, C. A., Wang, Y., Ashbaugh, A. G., Ortines, R. V., Kao, T., Lee, S. K., Cai, S. S., Miller, R. J., Marchitto, M. C., Zhang, E., Riggins, D. P., Plaut, R. D., Stibitz, S., Geha, R. S., & Miller, L. S. (2017). Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-mediated T cell responses. Cell Host & Microbe, 22, 653–666.

    Article  CAS  Google Scholar 

  • Liu, C. M., Price, L. B., Hungate, B. A., Abraham, A. G., Larsen, L. A., Christensen, K., Stegger, M., et al. (2015). Staphylococcus aureus and the ecology of the nasal microbiome. Science Advances, 1, e1400216.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lodge, C. J., Tan, D. J., Lau, M. X., Dai, X., Tham, R., Lowe, A. J., Bowatte, G., et al. (2015). Breastfeeding and asthma and allergies: A systematic review and meta-analysis. Acta Paediatrica, 104, 38–53.

    Article  PubMed  CAS  Google Scholar 

  • Majamaa, H., & Isolauri, E. (1997). Probiotics: A novel approach in the management of food allergy. The Journal of Allergy and Clinical Immunology, 99, 179–185.

    Article  PubMed  CAS  Google Scholar 

  • Masoli, M., Fabian, D., Holt, S., & Beasley, R. (2004). The global burden of asthma: Executive summary of the GINA Dissemination Committee report. Allergy, 59, 469–478.

    Article  PubMed  Google Scholar 

  • Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012). Reciprocal interactions of the intestinal microbiota and immune system. Nature, 489, 231–241.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., et al. (2017). Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Science Translational Medicine, 9. https://doi.org/10.1126/scitranslmed.aah4680

  • Noval Rivas, M., Burton, O. T., Wise, P., Zhang, Y. Q., Hobson, S. A., Garcia Lloret, M., Chehoud, C., et al. (2013). A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. The Journal of Allergy and Clinical Immunology, 131, 201–212.

    Article  PubMed  CAS  Google Scholar 

  • Oddy, W. H. (2009). The long-term effects of breastfeeding on asthma and atopic disease. Advances in Experimental Medicine and Biology, 639, 237–251.

    Article  PubMed  CAS  Google Scholar 

  • Oh, J., Byrd, A. L., Park, M., Program, N. C. S., Kong, H. H., & Segre, J. A. (2016). Temporal stability of the human skin microbiome. Cell, 165, 854–866.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ohnmacht, C., Park, J. H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., et al. (2015). Mucosal Immunology. The microbiota regulates type 2 immunity through RORgammat(+) T cells. Science, 349, 989–993.

    Article  PubMed  CAS  Google Scholar 

  • Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., et al. (2012). Microbial exposure during early life has persistent effects on natural killer T cell function. Science, 336, 489–493.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., et al. (2002). Endogenous antimicrobial peptides and skin infections in atopic dermatitis. The New England Journal of Medicine, 347, 1151–1160.

    Article  PubMed  CAS  Google Scholar 

  • Ouwehand, A. C., Isolauri, E., He, F., Hashimoto, H., Benno, Y., & Salminen, S. (2001). Differences in Bifidobacterium flora composition in allergic and healthy infants. The Journal of Allergy and Clinical Immunology, 108, 144–145.

    Article  PubMed  CAS  Google Scholar 

  • Oyama, N., Sudo, N., Sogawa, H., & Kubo, C. (2001). Antibiotic use during infancy promotes a shift in the T(H)1/T(H)2 balance toward T(H)2-dominant immunity in mice. The Journal of Allergy and Clinical Immunology, 107, 153–159.

    Article  PubMed  CAS  Google Scholar 

  • Pabst, O., & Mowat, A. M. (2012). Oral tolerance to food protein. Mucosal Immunology, 5, 232–239.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Palmer, C. N., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., et al. (2006). Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics, 38, 441–446.

    Article  PubMed  CAS  Google Scholar 

  • Panduru, M., Panduru, N. M., Salavastru, C. M., & Tiplica, G. S. (2015). Probiotics and primary prevention of atopic dermatitis: A meta-analysis of randomized controlled studies. Journal of the European Academy of Dermatology and Venereology, 29, 232–242.

    Article  PubMed  CAS  Google Scholar 

  • Penders, J., Gerhold, K., Stobberingh, E. E., Thijs, C., Zimmermann, K., Lau, S., & Hamelmann, E. (2013). Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. The Journal of Allergy and Clinical Immunology, 132, 601–607e608.

    Article  PubMed  Google Scholar 

  • Peters, R. L., Koplin, J. J., Gurrin, L. C., Dharmage, S. C., Wake, M., Ponsonby, A. L., Tang, M. L. K., et al. (2017). The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. The Journal of Allergy and Clinical Immunology, 140, 145–153e148.

    Article  PubMed  Google Scholar 

  • Platts-Mills, T. A. (2015). The allergy epidemics: 1870-2010. The Journal of Allergy and Clinical Immunology, 136, 3–13.

    Article  PubMed  PubMed Central  Google Scholar 

  • Plunkett, C. H., & Nagler, C. R. (2017). The influence of the microbiome on allergic sensitization to food. Journal of Immunology, 198, 581–589.

    Article  CAS  Google Scholar 

  • Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S., McCulle, S. L., Karlebach, S., et al. (2011). Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences of the United States of America, 108(Suppl 1), 4680–4687.

    Article  PubMed  Google Scholar 

  • Renz-Polster, H., David, M. R., Buist, A. S., Vollmer, W. M., O’Connor, E. A., Frazier, E. A., & Wall, M. A. (2005). Caesarean section delivery and the risk of allergic disorders in childhood. Clinical and Experimental Allergy, 35, 1466–1472.

    Article  PubMed  CAS  Google Scholar 

  • Rinaldi, M., Harnack, L., Oberg, C., Schreiner, P., St Sauver, J., & Travis, L. L. (2012). Peanut allergy diagnoses among children residing in Olmsted County, Minnesota. The Journal of Allergy and Clinical Immunology, 130, 945–950.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ring, J., Brockow, K., & Behrendt, H. (2004). History and classification of anaphylaxis. Novartis Foundation Symposium, 257, 6–16 discussion 16–24, 45–50, 276–285.

    PubMed  Google Scholar 

  • Rodriguez, B., Prioult, G., Bibiloni, R., Nicolis, I., Mercenier, A., Butel, M. J., & Waligora-Dupriet, A. J. (2011). Germ-free status and altered caecal subdominant microbiota are associated with a high susceptibility to cow’s milk allergy in mice. FEMS Microbiology Ecology, 76, 133–144.

    Article  PubMed  CAS  Google Scholar 

  • Russell, S. L., Gold, M. J., Hartmann, M., Willing, B. P., Thorson, L., Wlodarska, M., Gill, N., et al. (2012). Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Reports, 13, 440–447.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schröder, J. M. (2011). Antimicrobial peptides in healthy skin and atopic dermatitis. Allergology International, 60, 17–24.

    Article  PubMed  CAS  Google Scholar 

  • Schulz, O., Jaensson, E., Persson, E. K., Liu, X., Worbs, T., Agace, W. W., & Pabst, O. (2009). Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. The Journal of Experimental Medicine, 206, 3101–3114.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., et al. (2015). Mucosal Immunology. Individual intestinal symbionts induce a distinct population of RORgamma(+) regulatory T cells. Science, 349, 993–997.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Seite, S., Flores, G. E., Henley, J. B., Martin, R., Zelenkova, H., Aguilar, L., & Fierer, N. (2014). Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment. Journal of Drugs in Dermatology, 13, 1365–1372.

    PubMed  Google Scholar 

  • Sicherer, S. H., & Sampson, H. A. (2014). Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. The Journal of Allergy and Clinical Immunology, 133, 291–307 quiz 308.

    Article  PubMed  CAS  Google Scholar 

  • Sistek, D., Kelly, R., Wickens, K., Stanley, T., Fitzharris, P., & Crane, J. (2006). Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical and Experimental Allergy, 36, 629–633.

    Article  PubMed  CAS  Google Scholar 

  • Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly, Y. M., Glickman, J. N., et al. (2013). The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science, 341, 569–573.

    Article  PubMed  CAS  Google Scholar 

  • Song, H., Yoo, Y., Hwang, J., Na, Y. C., & Kim, H. S. (2016). Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. The Journal of Allergy and Clinical Immunology, 137, 852–860.

    Article  PubMed  CAS  Google Scholar 

  • Spergel, J. M. (2010). From atopic dermatitis to asthma: The atopic march. Annals of Allergy, Asthma, & Immunology, 105, 99–106 quiz 107–109, 117.

    Article  CAS  Google Scholar 

  • Stefka, A. T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S. K., Tjota, M. Y., et al. (2014). Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences of the United States of America, 111, 13145–13150.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Strachan, D. P. (1989). Hay fever, hygiene, and household size. BMJ, 299, 1259–1260.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sze, M. A., Tsuruta, M., Yang, S. W., Oh, Y., Man, S. F., Hogg, J. C., & Sin, D. D. (2014). Changes in the bacterial microbiota in gut, blood, and lungs following acute LPS instillation into mice lungs. PLoS One, 9, e111228.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tang, M. L., Ponsonby, A. L., Orsini, F., Tey, D., Robinson, M., Su, E. L., Licciardi, P., et al. (2015). Administration of a probiotic with peanut oral immunotherapy: A randomized trial. The Journal of Allergy and Clinical Immunology, 135, 737–744e738.

    Article  PubMed  CAS  Google Scholar 

  • Thorburn, A. N., McKenzie, C. I., Shen, S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., et al. (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nature Communications, 6, 7320.

    Article  PubMed  CAS  Google Scholar 

  • Tokumasu, R., Yamaga, K., Yamazaki, Y., Murota, H., Suzuki, K., Tamura, A., Bando, K., et al. (2016). Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proceedings of the National Academy of Sciences of the United States of America, 113, E4061–E4068.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Traidl-Hoffmann, C., Jakob, T., & Behrendt, H. (2009). Determinants of allergenicity. The Journal of Allergy and Clinical Immunology, 123, 558–566.

    Article  PubMed  CAS  Google Scholar 

  • Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., et al. (2014). Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nature Medicine, 20, 159–166.

    Article  PubMed  CAS  Google Scholar 

  • Velez, M. A., Perotti, M. C., Wolf, I. V., Hynes, E. R., & Zalazar, C. A. (2010). Influence of milk pretreatment on production of free fatty acids and volatile compounds in hard cheeses: Heat treatment and mechanical agitation. Journal of Dairy Science, 93, 4545–4554.

    Article  PubMed  CAS  Google Scholar 

  • Volz, T., Nega, M., Buschmann, J., Kaesler, S., Guenova, E., Peschel, A., Röcken, M., et al. (2010). Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals. The FASEB Journal, 24, 4089–4102.

    Article  PubMed  CAS  Google Scholar 

  • Volz, T., Skabytska, Y., Guenova, E., Chen, K. M., Frick, J. S., Kirschning, C. J., Kaesler, S., et al. (2014). Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells. The Journal of Investigative Dermatology, 134, 96–104.

    Article  PubMed  CAS  Google Scholar 

  • Waser, M., Michels, K. B., Bieli, C., Floistrup, H., Pershagen, G., von Mutius, E., Ege, M., et al. (2007). Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe. Clinical and Experimental Allergy, 37, 661–670.

    Article  PubMed  CAS  Google Scholar 

  • Watanabe, S., Narisawa, Y., Arase, S., Okamatsu, H., Ikenaga, T., Tajiri, Y., & Kumemura, M. (2003). Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. The Journal of Allergy and Clinical Immunology, 111, 587–591.

    Article  PubMed  Google Scholar 

  • Weiner, H. L., da Cunha, A. P., Quintana, F., & Wu, H. (2011). Oral tolerance. Immunological Reviews, 241, 241–259.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Werfel, T. (2015). Atopische dermatitis. In T. Biedermann, W. Heppt, H. Renz, & M. Röcken (Eds.), Allergologie (pp. 249–259). Berlin: Springer.

    Google Scholar 

  • Wölbing, F., & Biedermann, T. (2013). Anaphylaxis: Opportunities of stratified medicine for diagnosis and risk assessment. Allergy, 68, 1499–1508.

    Article  PubMed  Google Scholar 

  • Yamashita, H., Takahashi, K., Tanaka, H., Nagai, H., & Inagaki, N. (2012). Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model. Allergy, 67, 201–209.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, G. Q., Hu, H. J., Liu, C. Y., Zhang, Q., Shakya, S., & Li, Z. Y. (2016). Probiotics for prevention of atopy and food hypersensitivity in early childhood: A PRISMA-compliant systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore), 95, e2562.

    Article  Google Scholar 

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  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, München, Germany

    Florian Wölbing, Martin Köberle, Thomas Volz & Tilo Biedermann

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  1. Florian Wölbing
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  2. Martin Köberle
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  4. Tilo Biedermann
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Correspondence to Tilo Biedermann .

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  1. Chair of Nutrition and Immunology, Technical University Munich, Freising, Germany

    Dirk Haller

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Wölbing, F., Köberle, M., Volz, T., Biedermann, T. (2018). Microbiome and Diseases: Allergy. In: Haller, D. (eds) The Gut Microbiome in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-90545-7_12

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