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Macrolides, Reflux and Respiratory Disease

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Reflux Aspiration and Lung Disease

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Abstract

Macrolides are a family of compounds that belong to the polyketides class. They are characterised by a large macrocyclic lactone ring that is produced by chain extension of propionates to which one or more sugars (usually cladinose and desosamine) attach. Macrolides are widely used in healthcare, primarily owing to their antimicrobial properties. The spectrum of antimicrobial activity and tissue penetration makes them particularly suitable for respiratory infections (Gram-positive and some Gram-negative organisms, Chlamydia, Legionella, Mycobacteria and Mycoplasma) [1]. However, macrolides are increasingly being used for their immunomodulatory and prokinetic effects with newer agents having no discernible antimicrobial activity (e.g. Tacrolimus, Sirolimus and Everolimus) [2].

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Authors and Affiliations

  1. Hull York Medical School, University of Hull, Hull, UK

    Michael G. Crooks

  2. Hull and East Yorkshire Hospitals NHS Trust, Hull, UK

    Tamsin Nash

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  1. Michael G. Crooks
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  1. University of Hull, Hull York Medical School, Cottingham, East Yorkshire, United Kingdom

    Alyn H. Morice

  2. Castle Hill Hospital, RD Biomed Limited, Cottingham, East Yorkshire, United Kingdom

    Peter W. Dettmar

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Crooks, M.G., Nash, T. (2018). Macrolides, Reflux and Respiratory Disease. In: Morice, A., Dettmar, P. (eds) Reflux Aspiration and Lung Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-90525-9_25

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