Abstract
This chapter gives an overview of the development of current diagnostic criteria for REM sleep behaviour disorder (RBD) and specifies qualitative and quantitative diagnostic polysomnographic (PSG) criteria. Minor differences and controversies between the International Classification of Sleep Disorders (ICSD), Third Edition (ICSD-3), and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria will be discussed, as well as open issues. Apart from presenting the current diagnostic criteria for RBD, this chapter is an introduction to the subsequent series of chapters related to the diagnosis of RBD and other PSG findings, namely, Chap. 19 (Wing YK group), Chap. 20 (Cesari M and Jennum P), Chap. 21 (De Cock VC), Chap. 26 (Manni R and Terzaghi M) and Chap. 31 (Puligheddu M, Fiorini M and Ferri R). Finally, the chapter will also discuss current limitations in the diagnosis of RBD and their potential consequences and additionally refer to new screening methods for RBD and their potential future applications.
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References
American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien, Illinois: American Academy of Sleep Medicine; 2014.
Fernández-Arcos A, Iranzo A, Serradell M, Gaig C, Santamaria J. The clinical phenotype of idiopathic rapid eye movement sleep behavior disorder at presentation: A study in 203 consecutive patients. Sleep. 2016;39:121–32.
Fernández-Arcos A, Iranzo A, Serradell M, et al. Diagnostic value of isolated mentalis versus mentalis plus upper limb electromyography in idiopathic REM sleep behavior disorder patients eventually developing a neurodegenerative syndrome. Sleep. 2017;40. https://doi.org/10.1093/sleep/zsx025.
Diagnostic Classification Steering Committee, Thorpy MJ, Chairman. International classification of sleep disorders: diagnostic and coding manual. Rochester, MN: American Sleep Disorders Association; 1990.
Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorder of human REM sleep: a new category of parasomnia. Sleep. 1986;9:293–308.
American Academy of Sleep Medicine. International classification of sleep disorders, revised: diagnostic and coding manual. Chicago: American Academy of Sleep Medicine; 2001.
American Academy of Sleep Medicine. International classification of sleep disorders: diagnostic and coding manual. 2nd ed. Westchester: American Academy of Sleep Medicine; 2005.
Högl B, Stefani A, Videnovic A. Idiopathic REM sleep behaviour disorder and neurodegeneration—an update. Nat Rev Neurol. 2018;14:40–55.
Sixel-Doring F, Zimmermann J, Wegener A, Mollenhauer B, Trenkwalder C. The evolution of REM sleep behavior disorder in early Parkinson disease. Sleep. 2016;39:1737–42.
Stefani A, Gabelia D, Högl B, et al. Long-term follow-up investigation of isolated rapid eye movement sleep without atonia without rapid eye movement sleep behavior disorder: a pilot study. J Clin Sleep Med. 2015;11:1273–9.
Berry RB, Brooks R, Gamaldo CE, et al. For the American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. Version 2.4. Darien: American Academy of Sleep Medicine; 2017.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013.
Iranzo A, Santamaria J. Severe obstructive sleep apnea/hypopnea syndrome mimicking REM sleep behavior disorder. Sleep. 2005;28:203–6.
Gaig C, Iranzo A, Pujol M, Perez H, Santamaria J. Periodic limb movements during sleep mimicking REM sleep behavior disorder: a new form of periodic limb movement disorder. Sleep. 2017;40(3). https://doi.org/10.1093/sleep/zsw063.
Frauscher B, Iranzo A, Gaig C, et al. Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder. Sleep. 2012;35:835–47.
Lapierre O, Montplaisir J. Polysomnographic features of REM sleep behavior disorder: development of a scoring method. Neurology. 1992;42:1371–4.
Zhang J, Lam SP, Ho CK, et al. Diagnosis of REM sleep behavior disorder by video-polysomnographic study: is one night enough? Sleep. 2008;31:1179–85.
Ferri R, Manconi M, Plazzi G, et al. A quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorder. J Sleep Res. 2008;17:89–100.
Frauscher B, Gschliesser V, Brandauer E, et al. Video analysis of motor events in REM sleep behavior disorder. Mov Disord. 2007;22:1464–70.
Frauscher B, Gschliesser V, Brandauer E, Ulmer H, Poewe W, Högl B. The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. Sleep Med. 2009;10:174–81.
Sixel-Döring F, Trautmann E, Mollenhauer B, Trenkwalder C. Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? Sleep. 2014;37:431–8.
Santamaria J, Högl B, Trenkwalder C, Bliwise D. Scoring sleep in neurological patients: the need for specific considerations. Sleep. 2011;34:1283–4.
Frauscher B, Iranzo A, Högl B, et al. Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder. Sleep. 2008;31:724–31.
Frauscher B, Högl B. REM sleep behavior disorder. Discovery of REM sleep behavior disorder, clinical and laboratory diagnosis, and treatment. In: Chokorverty S, Allen RP, Walters AS, Montagna P, editors. Movement disorder in sleep. 2nd ed. Oxford: Oxford University Press; 2013. p. 406–22.
Ferri R, Rundo F, Manconi M, et al. Improved computation of the atonia index in normal controls and patients with REM sleep behavior disorder. Sleep Med. 2010;11:947–9.
Frandsen R, Nikolic M, Zoetmulder M, Kempfner L, Jennum P. Analysis of automated quantification of motor activity in REM sleep behaviour disorder. J Sleep Res. 2015;24:583–90.
Frauscher B, Gabelia D, Biermayr M, et al. Validation of an integrated software for the detection of rapid eye movement sleep behavior disorder. Sleep. 2014;37:1663–71.
Haba-Rubio J, Frauscher B, Marques-Vidal P, et al. Prevalence and determinants of REM sleep behavior disorder in the general population. Sleep. 2017. https://doi.org/10.1093/sleep/zsx197.
Schenck CH, Bundlie SR, Patterson AL, Mahowald MW. Rapid eye movement sleep behavior disorder. A treatable parasomnia affecting older adults. JAMA. 1987;257:1786–9.
Manni R, Terzaghi M, Glorioso M. Motor-behavioral episodes in REM sleep behavior disorder and phasic events during REM sleep. Sleep. 2009;32:241–5.
Bugalho P, Lampreia T, Miguel R, Mendonça M, Caetano A, Barbosa R. Characterization of motor events in REM sleep behavior disorder. J Neural Transm. 2017;124:1183–6.
Stefani A, Heidbreder A, Brandauer E, et al. Screening for idiopathic REM sleep behavior disorder: Usefulness of actigraphy. Sleep 2018;41(6). https://doi.org/10.1093/sleep/zsy053.
Arnulf I, Uguccioni G, Gay F, Baldayrou E, Golmard JL, Gayraud F, Devevey A. What does the sleeping brain say? Syntax and semantics of sleep talking in healthy subjects and in Parasomnia patients. Sleep. 2017;40. https://doi.org/10.1093/sleep/zsx159.
Rusz J, Hlavnička J, Tykalová T, Bušková J, Ulmanová O, Růžička E, Šonka K. Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder. Sleep Med. 2016;19:141–7.
Hlavnička J, Čmejla R, Tykalová T, Šonka K, Růžička E, Rusz J. Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder. Sci Rep. 2017;7:12.
Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? Neurology. 2004;62:41–5.
St Louis EK, Boeve AR, Boeve BF. REM sleep behavior disorder in Parkinson’s disease and other synucleinopathies. Mov Disord. 2017;32:645–58.
Iranzo A, Santamaria J, Tolosa E. Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions. Lancet Neurol. 2016;15:405–19.
Iranzo A, Stefani A, Serradell M, et al. Characterization of patients with longstanding idiopathic REM sleep behavior disorder. Neurology. 2017;89:242–8.
Sasai-Sakuma T, Frauscher B, Mitterling T, et al. Quantitative assessment of isolated rapid eye movement (REM) sleep without atonia without clinical REM sleep behavior disorder: clinical and research implications. Sleep Med. 2014;15:1009–15.
Halsband C, Zapf A, Sixel-Döring F, Trenkwalder C, Mollenhauer B. The REM Sleep Behavior Disorder Screening Questionnaire is not valid in de novo Parkinson’s disease. Mov Disord Clin Pract. 2018;5:171–6.
Pujol M, Pujol J, Alonso T, et al. Idiopathic REM sleep behavior disorder in the elderly Spanish community: a primary care center study with a two-stage design using video-polysomnography. Sleep Med. 2017;40:116–21.
Postuma RB, Pelletier A, Berg D, Gagnon JF, Escudier F, Montplaisir J. Screening for prodromal Parkinson’s disease in the general community: a sleep-based approach. Sleep Med. 2016;21:101–5.
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Stefani, A., Frauscher, B., Högl, B. (2019). Diagnosis of REM Sleep Behavior Disorder. In: Schenck, C., Högl, B., Videnovic, A. (eds) Rapid-Eye-Movement Sleep Behavior Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-90152-7_18
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