Abstract
Polypharmacy is a major issue for individuals with intellectual disability. There have been many proposed definitions of polypharmacy, including using five or more medications. Individuals with intellectual disability are at increased risk for polypharmacy given the presence of multiple co-morbidities such as mental health and neurologic conditions. Commonly prescribed medications for patients with intellectual disability include antipsychotics, anti-epileptics, and antidepressants. Common adverse effects of these medications include sedation, insomnia, nausea, constipation, and weight gain. Importantly, there are strategies that can help reduce polypharmacy and its negative effects, including medication reconciliation tools and processes such as the Systematic Tool to Reduce Inappropriate Prescribing (STRIP).
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References
Deb S, Farmah BK, Arshad E, Deb T, Roy M, Unwin GL. The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autistic spectrum disorder – a systematic review. Res Dev Disabil. 2014;35:711–25.
Haider SI, Ansari Z, Vaughan L, Matters H, Emerson E. Prevalence and factors associated with polypharmacy in Victorian adults with intellectual disability. Res Dev Disabil. 2014;35:3071–80.
Stortz JN, Johanna KL, Cobigo V, Ouellette-Kuntz HMJ, Lunsky Y. Lessons learned from our elders: How to study polypharmacy in populations with intellectual and developmental disabilities. Intellect Dev Disabil. 2014;52:60–77.
O’Dwyer M, Peklar J, McCallion P, McCarron M, Henman MC. Factors associated with polypharmacy and excessive polypharmacy in older people with intellectual disability differ from the general population: a cross-sectional observational nationwide study. BMJ Open. 2016;6:e010505.
Tonge B, Einfeld S. The trajectory of psychiatric disorders in young people with intellectual disabilities. Aust N Z J Psychiatry. 2000;34:80–4.
Deb S, Unwin G, Deb T. Characteristics and the trajectory of psychotropic medication use in general and antipsychotics in particular among adults with an intellectual disability who exhibit aggressive behaviour. J Intellect Disabil Res. 2015;59:11–25.
Scheifes A, Egberts TCG, Stolker JJ, Nijman HLI, Heerdink ER. Structured medication review to improve pharmacotherapy in people with intellectual disability and behavioural problems. J Appl Res Intellect Disabil. 2016;29:346–55.
Lott IT, McGregor M, Engelman L, Touchette P, Tournay A, Sandman C, Walsh D. Longitudinal prescribing patterns for psychoactive medications in community-based individuals with developmental disabilities: Utilization of pharmacy records. J Intellect Disabil Res. 2004;48:563–71.
Eady N, Courtenay K, Strydom A. Pharmacological management of behavioral and psychiatric symptoms in older adults with intellectual disability. Drugs Aging. 2015;32:95–102.
Arvio M, Sillanpaa M. Prevalence, aetiology, and comorbidity of severe and profound intellectual disability (SPID) in Finland. J Intellect Disabil Res. 2004;48:429.
Häβler F, Thome J, Reis O. Polypharmacy in the treatment of subjects with intellectual disability. J Neural Transm (Vienna). 2015;122:S93–S100.
van der Heide DC, van der Putten AAJ, van den Berg PB, Taxis K, Vlaskamp C. The documentation of health problems in relation to prescribed medication in people with profound intellectual and multiple disabilities. J Intellect Disabil Res. 2009;53:161–8.
Mahan S, Holloway J, Bamburg JW, Hess JA, Fodstad JC, Matson JL. An examination of psychotropic medication side effects: Does taking a greater number of psychotropic medications from different classes affect presentation of side effects in adults with ID? Res Dev Disabil. 2010;31:1561–9.
Jackson C, Makin S, Marson A, Kerr M. Pharmacological interventions for epilepsy in people with intellectual disabilities. Cochrane Database Syst Rev. 2015;3(9):CD005399.
Matson JL, Mahan S. Antipsychotic drug side effects for persons with intellectual disability. Res Dev Disabil. 2010;31:1570–6.
Molina-Ruiz RM, MartÃn-Carballeda J, Asensio-Moreno I, Montañés-Rada F. A guide to psychopharmacological treatment of patients with intellectual disability in psychiatry. Int J Psychiatry Med. 2017;52:176–89.
McQuire C, Hassiotis A, Harrison B, Pilling S. Pharmacological interventions for challenging behaviour in children with intellectual disabilities: a systematic review and meta-analysis. BMC Psychiatry. 2015;15:303. https://doi.org/10.1186/s12888-015-0688-2.
Ji NY, Findling RL. Pharmacotherapy for mental health problems in people with intellectual disability. Curr Opin Psychiatry. 2016;29:103–25.
Ayub M, Saeed K, Munshi TA, Naeem F. Clozapine for psychotic disorders in adults with intellectual disabilities. Cochrane Database Syst Rev. 2015;23(9):Cd010625.
Rana F, Gormez A, Varghese S. Pharmacological interventions for self-injurious behaviour in adults with intellectual disabilities: abridged republication of a Cochrane systematic review. J Psychopharmacol. 2014;28:624–32.
Selph C, Cosca B. Less is more: preventing polypharmacy in individuals with intellectual disabilities. Impact. 2016;29:28–9. Retrieved from https://ici.umn.edu/products/impact/291/291.pdf.
Special Olympics International. MedFest medication watch list. Retrieved from http://resources.specialolympics.org/Taxonomy/Health/_Catalog_of_MedFest.aspx.
Matson JL, Cervantes PE. Current status of the matson evaluation of drug side effects (MEDS). Res Dev Disabil. 2013;34:1849–53.
Zaal RJ, Ebbers S, Borms M, de Koning B, Mombarg E, Ooms PE, M H. Medication review using a systematic tool to reduce inappropriate prescribing (STRIP) in adults with an intellectual disability: A pilot study. Res Dev Disabil. 2016;55:132–42.
Modi M, McMorris C, Palucka A, Raina P, Lunsky Y. Predictors of specialized inpatient admissions for adults with intellectual disability. Am J Intellect Dev Disabil. 2015;120:46–57.
Kalachnik JE, Sprague RL. The dyskinesia identification system condensed user scale (DISCUS): relability, validity, and a total score cut-off for mentally ill and mentally retarded populations. J Clin Psychiatry. 1993;49:177–89.
Trollor JN, Salomon C, Franklin C. Prescribing psychotropic drugs to adults with an intellectual disability. Aust Prescr. 2016;39:126–30.
Deb S, Matthews T, Holt G, Bouras N. Practice guidelines for the assessment and diagnosis of mental health problems in adults with intellectual disability. Res Dev Disabil. 2002;23:234–5.
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Cornacchia, M., Chandan, P. (2019). Psychotropic Polypharmacy. In: Prasher, V., Janicki, M. (eds) Physical Health of Adults with Intellectual and Developmental Disabilities. Springer, Cham. https://doi.org/10.1007/978-3-319-90083-4_16
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