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Endophytes of Forest Trees pp 441–462Cite as

Potential of Tree Endophytes as Sources for New Drug Compounds

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Part of the book series: Forestry Sciences ((FOSC,volume 86))

Abstract

The novel or designer metabolites produced by fungal endophytes are increasingly recognized by natural chemists due to their diverse structures and as candidates for drug discovery and development. Many of the metabolites belong to different classes i.e., alkaloids, benzopyranones, coumarins, chromones, cytochalasines, enniatines, isocoumarin derivatives, quinones, peptides, phenols, phenolic acids, semiquinones, steroids, terpenoids, xanthones and lactones. One of the most widely studied endophytic genera is Pestalotiopsis, from which more than 140 metabolites are reported with antimicrobial, antioxidant and antitumor activities. Here we update on the advances made on identifying bioactive metabolites with drug development potential from endophytic fungi. Furthermore, we look into the most recent innovations on improving the exploitation of endophytic fungi and their products by the pharmaceutical industry. Our main emphasis lies on the anti-infective discovery in the view of developing new drug compounds from endophytic products.

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Abbreviations

ACE:

Angiotensin I-converting enzyme

AIDS:

Acquired Immune Deficiency Syndrome

CFME:

Cell-free metabolic engineering

DGGE:

Denaturing Gradient Gel Electrophoresis

EMEA:

European Agency for the Evaluation of Medicinal Products

FDA:

Food and Drug Administration

HI:

Human immunodeficiency

IC50:

The half maximal inhibitory concentration

MIC:

Minimum inhibitory concentration

NDM-1:

New Delhi metallo-beta-lactamase

RFLP:

Restriction Fragment Length Polymorphism

SARS:

Severe acute respiratory syndrome

TB:

Tuberculosis

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Authors and Affiliations

  1. Ecology and Genetics, University of Oulu, Oulu, Finland

    Mysore V. Tejesvi & Anna Maria Pirttilä

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  1. Mysore V. Tejesvi
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  2. Anna Maria Pirttilä
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Correspondence to Mysore V. Tejesvi .

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  1. Ecology and Genetics, University of Oulu, Oulu, Finland

    Anna Maria Pirttilä

  2. School of Natural Sciences, University of California, Merced, Merced, California, USA

    A. Carolin Frank

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Tejesvi, M.V., Pirttilä, A.M. (2018). Potential of Tree Endophytes as Sources for New Drug Compounds. In: Pirttilä, A., Frank, A. (eds) Endophytes of Forest Trees. Forestry Sciences, vol 86. Springer, Cham. https://doi.org/10.1007/978-3-319-89833-9_17

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