Abstract
Molecular diagnosis (MD), or component-resolved diagnosis in allergy, consists of detecting specific IgE to different allergens. In this chapter is described how molecular diagnosis may increase diagnostic accuracy in patients with contact urticaria induced by proteins of the vegetal and animal kingdoms, how to recognize allergens associated with genuine sensitization from allergens with cross-reactivity, and how some allergens are associated with clinical reactions. Nevertheless, all in vitro test results should be evaluated in conjunction with the clinical history, because allergen sensitization does not necessarily imply clinical responsiveness. In general, molecular diagnosis provides us specificity in the diagnosis; however, to have enough diagnostic sensitivity, the skin prick test or specific IgE with whole standardized extracts is required.
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Abbreviations
- Abs:
-
antibodies
- CCD:
-
Cross-reactive carbohydrate determinants
- LTP:
-
Lipid transfer proteins
- MD:
-
Molecular diagnosis
- OAS:
-
Oral allergy syndrome
- PR 10 protein:
-
Pathogenesis-related protein 10
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Acknowledgments
I thank Oliver Shaw for editorial assistance.
Conflicts of Interest
The author reports having served as a consultant to Thermo Fisher, MSD, Novartis, Genentech, Sanofi, Leti, Roche and GSK; having been paid lecture fees by Novartis, GSK, Stallergenes, LE as well as having received grant support for research from Thermo Fisher, GSK, and ALK-Abello.
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Sastre, J. (2018). Molecular Diagnosis in Contact Urticaria Caused by Proteins. In: Giménez-Arnau, A., Maibach, H. (eds) Contact Urticaria Syndrome. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-89764-6_11
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