Abstract
Ethyl6-methyl-2-oxo-4-phenyl-1,2,3,4 tetrahydropyrimidine-5-carboxylate, Bigenilli product (noted DHPMs) was synthesized in the presence of chlorides and nitrates of metals as catalysts, in mild free solvent conditions. High DHPM yields were obtained with Zn(NO3)2 (97%), ZnCl2 (90%) and CuCl2 (76%). The reaction heptagram inspired by the principles of green chemistry show that in our reaction conditions, Biginelli process complies with the principles of sustainable development.
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Bennini, L., Mazari, T., Khiar, C., Menad, S., Halouane, M., Rabia, C. (2018). Zinc Based Materials as Efficient Catalysts for a Clean Synthesis of Biginelli Product. In: Abdelbaki, B., Safi, B., Saidi, M. (eds) Proceedings of the Third International Symposium on Materials and Sustainable Development. SMSD 2017. Springer, Cham. https://doi.org/10.1007/978-3-319-89707-3_39
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DOI: https://doi.org/10.1007/978-3-319-89707-3_39
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