Abstract
The present paper reveals the potential uses of grafted hydrogel of Alginate-g-poly(2-hydroxyethyl methacrylate-co-acrylic acid) in controlled drug delivery. The graft copolymerization reaction was carried out in a homogeneous medium, in the presence of potassium persulfate (KPS) as initiator and N, N’-methylenebisacrylamide (MBA) as crosslinker. The grafting Efficiency was calculated and found to be 77.47%.
To investigate the structure of the obtained hydrogel, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and Differential scanning calorimetry (DSC) were used. Swelling behavior of the obtained hydrogel in different pH media was investigated. It was found that the synthesized hydrogel has a high pH sensitivity. Drug loading and controlled release properties of the grafted hydrogel, in both stimulated gastric (pH 1.2) and stimulated intestinal (pH 7.4) media at 37 °C, were also evaluated using Tramadol chlorhydrate as model drug. The kinetics of drug release from hydrogel matrices has been examined using several mathematical models. The results showed that the best fitted curves were obtained with Higuchi model. The in vitro release suggests that this hydrogel can be considered as an excellent candidate to design novel drug delivery systems.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abd El-Rehim, H.A.: Characterization and possible agricultural application of polyacrylamide/sodium alginate crosslinked hydrogels prepared by ionizing radiation. J. Appl. Polym. Sci. 101, 3572–3580 (2006)
AL-Kahtani, A.A., Sherigara, B.S.: Semi-interpenetrating network of acrylamide-grafted-sodiumalginate microspheres for controlled release of diclofenac sodium, preparation and characterization. Colloids Surf., B 115, 132–138 (2014)
Daniele, M.A., Adams, A.A., Naciri, J., North, S.H., Ligler, F.S.: Interpenetrating networks based on gelatin methacrylamide and PEG formed using concurrent thiol click chemistries for hydrogel tissue engineering scaffolds. Biomaterials 35, 1845–1856 (2014)
La, Y.H., McCloskey, B.D., Sooriyakumaran, R., Vora, A., Freeman, B., Nassar, M., Hedrick, J., Nelson, A., Allen, R.: Bifunctional hydrogel coatings for water purification membranes: improved fouling resistance and antimicrobial activity. J. Membr. Sci. 372, 285–291 (2011)
Mandal, B., Ray, S.K.: Synthesis of interpenetrating network hydrogel from poly(acrylic acid-co-hydroxyethyl methacrylate) and sodium alginate: Modeling and kinetics study for removal of synthetic dyes from water. Carbohydr. Polym. 98, 257–269 (2013)
Nehls, E.M., Rosales, A.M., Anseth, K.S.: Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel viaazobenzene/cyclodextrin complex tethers. J. Mater. Chem. B 4, 1035–1039 (2016)
Wang, W., Wang, A.: Synthesis and swelling properties of pH sensitive semi-IPN superabsorbent hydrogels based on sodium alginate-g-poly(sodium acrylate) and polyvinylpyrrolidone. Carbohydr. Polym. 80, 1028–1036 (2010)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this paper
Cite this paper
Bounabi, L., Bouslah Mokhnachi, N., Haddadine, N., Benaboura, A. (2018). Controlling Drug Release Through Poly(2-Hydroxyethylmethacrylate-co-acrylic Acid) Grafted Sodium Alginate. In: Abdelbaki, B., Safi, B., Saidi, M. (eds) Proceedings of the Third International Symposium on Materials and Sustainable Development. SMSD 2017. Springer, Cham. https://doi.org/10.1007/978-3-319-89707-3_15
Download citation
DOI: https://doi.org/10.1007/978-3-319-89707-3_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-89706-6
Online ISBN: 978-3-319-89707-3
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)