Skip to main content

Urine Cytology

  • Chapter
  • First Online:
Atlas of Non-Gynecologic Cytology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

  • 1248 Accesses

Abstract

Urine cytology is a convenient method by which clinicians can screen and triage patients with urinary symptoms as well as a history of exposure to bladder-toxic agents. This chapter reviews cytologic findings in a variety of urine specimens with variable degrees of atypia and highlights the criteria for specific diagnoses in the Paris System for Reporting Urinary Cytology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rosenthal DL, Wojcik EM, Kurtycz DFI, editors. The Paris System for reporting urinary cytology. New York: Springer; 2016.

    Google Scholar 

  2. Studeman KD, Loffe OB, Puszkiewicz J, Sauvegeot J, Henry MR. Effect of cellularity on the sensitivity of detected squamous lesions in liquid-based cervical cytology. Acta Cytol. 2003;47:605–10.

    Article  PubMed  Google Scholar 

  3. Michael CW, Pang Y, Pu RT, Hasteh F, Griffith KA. Cellular adequacy for thyroid aspirates prepared by ThinPrep: how many cells are needed? Diagn Cytopathol. 2007;68:792–7.

    Article  Google Scholar 

  4. Prather J, Arville B, Grazina Chatt CT, Pambuccian SE, Wojcik EM, Quek ML, Barkan GA. Evidence-based adequacy criteria for urinary bladder barbotage cytology. J Am Soc Cytopathol. 2015;4:57–62.

    Article  Google Scholar 

  5. Chau K, Rosen L, Coutsouvelis C, Fenelus M, Brenkert R, Klein M, et al. Accuracy and risk of malignancy for diagnostic categories in urine cytology at a large tertiary institution. Cancer Cytopathol. 2015;123:10–8.

    Article  PubMed  Google Scholar 

  6. Brimo F, Vollmer RT, Case B, Aprikian A, Kassouf W, Auger M. Accuracy of urine cytology and the significance of an atypical category. Am J Clin Pathol. 2009;132:785–93.

    Article  PubMed  Google Scholar 

  7. Raab SS, Grzybicki DM, Vrbin CM, Geisinger KR. Urine cytology discrepancies: frequency, causes, and outcomes. Am J Clin Pathol. 2007;127:946–53.

    Article  PubMed  Google Scholar 

  8. Mokhtar GA, Al-Dousari M, Al-Ghamedi D. Diagnostic significance of atypical category in the voided urine samples: a retrospective study in a tertiary care center. Urol Ann. 2010;2:100–6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rosenthal DL, Vandenbussche CJ, Burroughs FH, Sathiyamoorthy S, Guan H, Owens C. The Johns Hopkins Hospital template for urologic cytology samples I. Creating the template. Cancer Cytopathol. 2013;121:15–20.

    Article  PubMed  Google Scholar 

  10. Halling KC, King W, Sokolova IA, Meyer RG, Burkhardt HM, Halling AC, et al. A comparison of cytology and fluorescence in situ hybridization for the detection of urothelial carcinoma. J Urol. 2000;164:1768–75.

    Article  CAS  PubMed  Google Scholar 

  11. Bastacky S, Ibrahim S, Wilczynski SP, Murphy WM. The accuracy of urinary cytology in daily practice. Cancer Cytopathol. 1999;87:118–28.

    Article  CAS  Google Scholar 

  12. Beyer-Boon ME, de Voogt HJ, van der Velde EA, Brussee JA, Schaberg A. The efficacy of urinary cytology in the detection of urothelial tumours. Sensitivity and specificity of urinary cytology. Urol Res. 1978;6:3–12.

    Article  CAS  PubMed  Google Scholar 

  13. Boon L, Bianchini E, Altavilla G. Polyomavirus infection versus high grade bladder carcinoma. Acta Cytol. 1989;33:887–93.

    PubMed  CAS  Google Scholar 

  14. Cibas ES, Ducatman BS, editors. Cytology: diagnostic principles and clinical correlates. Philadelphia: Saunders/Elsevier; 2014.

    Google Scholar 

  15. Schistosomiasis fact sheet. World Health Organization. 2017. http://www.who.int/mediacentre/factsheets/fs115/en. Accessed 5 Nov 2017.

  16. Owens CL, Vandenbussche CJ, Burroughs FH, Rosenthal DL. A review of reporting systems and terminology for urine cytology. Cancer Cytopathol. 2013;121:9–14.

    Article  PubMed  Google Scholar 

  17. Bostwick DG, Hossain D. Does subdivision of the “atypical” urine cytology increase predictive accuracy for urothelial carcinoma? Diagn Cytopathol. 2014;42:1034–44.

    Article  PubMed  Google Scholar 

  18. VandenBussche CJ, Sathiyamoorthy S, Owens CL, Burroughs FH, Rosenthal DL, Guan H. The Johns Hopkins Hospital template for urologic cytology samples: parts II and III: improving the predictability of indeterminate results in urinary cytologic samples: an outcomes and cytomorphologic study. Cancer Cytopathol. 2013;121:21–8.

    Article  PubMed  Google Scholar 

  19. Glass R, Cocker R, Rosen L, Coutsouvelis C, Chau K, Slim F, et al. The impact of subdividing the “atypical” category for urinary cytology on patient management. Diagn Cytopathol. 2016;44:477–82.

    Article  PubMed  Google Scholar 

  20. Granados R, Duarte JA, Corrales T, Camarmo E, Bajo P. Applying the Paris System for reporting urine cytology increases the rate of atypical urothelial cells in benign cases: a need for patient management recommendations. Acta Cytol. 2016;61:71–6.

    Article  CAS  PubMed  Google Scholar 

  21. Murphy WM, Soloway MS, Jukkola AF, Crabtree WN, Ford KS. Urinary cytology and bladder cancer. The cellular features of transitional cell neoplasms. Cancer. 1984;53:1555–65.

    Article  CAS  PubMed  Google Scholar 

  22. Raab S, Lenel J, Cohen M. Low grade transitional cell carcinoma of the bladder. Cytologic diagnosis by key features as identified by logistic regression analysis. Cancer. 1994;74:1621–6.

    Article  CAS  PubMed  Google Scholar 

  23. Renshaw AA, Nappi D, Weinberg DS. The cytology of grade 1 papillary transitional cell carcinoma: a comparison of cytologic, architectural, and morphometric criteria in cystoscopically obtained urine. Acta Cytol. 1996;40:676–82.

    Article  CAS  PubMed  Google Scholar 

  24. McCroskey Z, Bahar B, Hu Z, Wojcik EM, Barkan GA. Subclassifying atypia in urine cytology: what are the helpful features? J Am Soc Cytopathol. 2015;4:183–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Madelyn Lew M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lew, M. (2018). Urine Cytology. In: Jing, X., Siddiqui, M., Li, Q. (eds) Atlas of Non-Gynecologic Cytology . Atlas of Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-89674-8_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-89674-8_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-89673-1

  • Online ISBN: 978-3-319-89674-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics